Core–Shell Polyvinyl Alcohol (PVA) Base Electrospinning Microfibers for Drug Delivery

Mares-Bou, Sofía; Serrano, María-Antonia; Gómez-Tejedor, José A.

doi:10.3390/polym15061554

Cited by 12 publications

(6 citation statements)

References 51 publications

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“…In the present study, the cumulative release of retinol, M ( t ), should satisfy the differential equation M ′( t ) = R ( t ) M ( t ), where R ( t ) is the time-dependent rate of retinol release. The time dependence of R ( t ) reflects the decrease in the rate of release with time [ 56 , 83 , 85 ]. Under such general conditions, we can represent the time-dependent rate of release as a power law of the form R ( t ) = kt m−1 , where 0 ≤ m ≤ 1 and k is the rate constant for retinol release.…”

Section: Resultsmentioning

confidence: 99%

Fabrication, Physical–Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications

Zamora-Ledezma,

Hernández,

López-González

et al. 2023

Polymers

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Nowadays, there exists a huge interest in producing innovative, high-performance, biofunctional, and cost-efficient electrospun biomaterials based on the association of biocompatible polymers with bioactive molecules. Such materials are well-known to be promising candidates for three-dimensional biomimetic systems for wound healing applications because they can mimic the native skin microenvironment; however, many open questions such as the interaction mechanism between the skin and the wound dressing material remain unclear. Recently, several biomolecules were intended for use in combination with poly(vinyl alcohol) (PVA) fiber mats to improve their biological response; nevertheless, retinol, an important biomolecule, has not been combined yet with PVA to produce tailored and biofunctional fiber mats. Based on the abovementioned concept, the present work reported the fabrication of retinol-loaded PVA electrospun fiber mats (RPFM) with a variable content of retinol (0 ≤ Ret ≤ 25 wt.%), and their physical–chemical and biological characterization. SEM results showed that fiber mats exhibited diameters distribution ranging from 150 to 225 nm and their mechanical properties were affected with the increasing of retinol concentrations. In addition, fiber mats were able to release up to 87% of the retinol depending on both the time and the initial content of retinol. The cell culture results using primary mesenchymal stem cell cultures proved the biocompatibility of RPFM as confirmed by their effects on cytotoxicity (low level) and proliferation (high rate) in a dose-dependent manner. Moreover, the wound healing assay suggested that the optimal RPFM with retinol content of 6.25 wt.% (RPFM-1) enhanced the cell migratory activity without altering its morphology. Accordingly, it is demonstrated that the fabricated RPFM with retinol content below the threshold 0 ≤ Ret ≤ 6.25 wt.% would be an appropriate system for skin regenerative application.

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Section: Resultsmentioning

confidence: 99%

Fabrication, Physical–Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications

Zamora-Ledezma,

Hernández,

López-González

et al. 2023

Polymers

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“…With the continuous development of the nano era, it has gradually become a major direction of study to apply nanomaterials in drug delivery systems [ 51 ]. Electrospun fibers have been broadly applied in drug delivery [ 52 , 53 , 54 , 55 , 56 , 57 ]. This is because the drug in the fibers exists in an amorphous form, which effectively improves the solubility and bioavailability of insoluble drugs.…”

Section: Introductionmentioning

confidence: 99%

Engineered Shellac Beads-on-the-String Fibers Using Triaxial Electrospinning for Improved Colon-Targeted Drug Delivery

et al. 2023

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Colon-targeted drug delivery is gradually attracting attention because it can effectively treat colon diseases. Furthermore, electrospun fibers have great potential application value in the field of drug delivery because of their unique external shape and internal structure. In this study, a core layer of hydrophilic polyethylene oxide (PEO) and the anti-colon-cancer drug curcumin (CUR), a middle layer of ethanol, and a sheath layer of the natural pH-sensitive biomaterial shellac were used in a modified triaxial electrospinning process to prepare beads-on-the-string (BOTS) microfibers. A series of characterizations were carried out on the obtained fibers to verify the process–shape/structure–application relationship. The results of scanning electron microscopy and transmission electron microscopy indicated a BOTS shape and core–sheath structure. X-ray diffraction results indicated that the drug in the fibers was in an amorphous form. Infrared spectroscopy revealed the good compatibility of the components in the fibers. In vitro drug release revealed that the BOTS microfibers provide colon-targeted drug delivery and zero-order drug release. Compared to linear cylindrical microfibers, the obtained BOTS microfibers can prevent the leakage of drugs in simulated gastric fluid, and they provide zero-order release in simulated intestinal fluid because the beads in BOTS microfibers can act as drug reservoirs.

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“…Tai Chi is a traditional Chinese boxing technique that inculcates skill both inside and outside, which has the effect of strengthening the body and nourishing the temperament. , Inspired by this, a novel strategy of both internal and external cultivation was developed to resist high temperature and achieve stronger flame retardancy. Coaxial electrospinning is a special process that can aid in the preparation of core–shell nanofibers with special structures and functions. , It can cleverly combine the functions of two or more substances to improve the overall performance. Peng prepared the PAN@SDBS separator by coaxial electrospinning, which realized the inhibition of ion diffusion driven by the solubility gradient.…”

Section: Introductionmentioning

confidence: 99%

“…Coaxial electrospinning is a special process that can aid in the preparation of core−shell nanofibers with special structures and functions. 37,38 It can cleverly combine the functions of two or more substances to improve the overall performance. Peng 42 prepared the PAN@ SDBS separator by coaxial electrospinning, which realized the inhibition of ion diffusion driven by the solubility gradient.…”

Section: Introductionmentioning

confidence: 99%

Coaxial Electrospun Tai Chi-Inspired Lithium-Ion Battery Separator with High Performance and Fireproofing Capacity

Zeng,

Shao,

Shen

et al. 2023

ACS Appl. Mater. Interfaces

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Organic flame-retardant-loaded battery separator offers a new opportunity for battery safety. However, its poor thermal stability still poses serious safety issues. Inspired by Tai Chi, an "internal-cultivating and external-practicing" core−shell nanofibrous membrane was prepared by coaxial electrospinning, wherein the shell layer was a mixture of polyvinylidene fluoride, silicon dioxide (SiO 2 ), and graphene oxide (GO) and the core layer contained triphenyl phosphate (TPP). SiO 2 and GO enhanced the thermal stability and electrochemical performance. The encapsulated TPP prevented heat transfer and the degradation of electrochemical performance caused by its direct dissolution. This separator exhibited outstanding thermal stability and flame retardancy: it did not burn and remained relatively intact (91.2%) in an open flame for 15 s. The battery assembled with a composite separator showed excellent performance: the initial capacity reached 164 mA h/g and maintained 95% after 100 charge− discharge cycles. This novel strategy endows high-performance lithium batteries with relatively higher safety.

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Core–Shell Polyvinyl Alcohol (PVA) Base Electrospinning Microfibers for Drug Delivery

Cited by 12 publications

References 51 publications

Fabrication, Physical–Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications

Fabrication, Physical–Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications

Engineered Shellac Beads-on-the-String Fibers Using Triaxial Electrospinning for Improved Colon-Targeted Drug Delivery

Coaxial Electrospun Tai Chi-Inspired Lithium-Ion Battery Separator with High Performance and Fireproofing Capacity

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