Corn gluten hydrolysate and capsaicin have complimentary actions on body weight reduction and lipid-related genes in diet-induced obese rats

Mun, Joo Mi; Ok, Hyang Mok; Kwon, Oran

doi:10.1016/j.nutres.2014.04.009

Cited by 16 publications

(13 citation statements)

References 38 publications

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“…Previous studies have reported that optimized dose of CAP may significantly affect fat oxidation and energy expenditure [12,26]. Thus, we found the CAP-2X groups showed a significant decrease in food consumption, but not in other CAP groups, which was consistent with previous study.…”

Section: Discussionsupporting

confidence: 92%

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

et al. 2016

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Chili pepper is used as a food, seasoning and has been revered for its medicinal and health claims. It is very popular and is the most common spice worldwide. Capsaicin (CAP) is a major pungent and bioactive phytochemical in chili peppers. CAP has been shown to improve mitochondrial biogenesis and adenosine triphosphate (ATP) production. However, there is limited evidence around the effects of CAP on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of CAP on anti-fatigue and ergogenic functions following physiological challenge. Female Institute of Cancer Research (ICR) mice from four groups (n = 8 per group) were orally administered CAP for 4 weeks at 0, 205, 410, and 1025 mg/kg/day, which were respectively designated the vehicle, CAP-1X, CAP-2X, and CAP-5X groups. The anti-fatigue activity and exercise performance was evaluated using forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, BUN (blood urea nitrogen) and creatine kinase (CK) after a 15-min swimming exercise. The grip strength and exhaustive swimming time of the CAP-5X group were significantly higher than other groups. CAP supplementation dose-dependently reduced serum lactate, ammonia, BUN and CK levels, and increased glucose concentration after the 15-min swimming test. In addition, CAP also increased hepatic glycogen content, an important energy source for exercise. The possible mechanism was relevant to energy homeostasis and the physiological modulations by CAP supplementation. Therefore, our results suggest that CAP supplementation may have a wide spectrum of bioactivities for promoting health, performance improvement and fatigue amelioration.

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Section: Discussionsupporting

confidence: 92%

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

et al. 2016

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“…1). The doses of YPh (500, 250 and 125 mg/kg) were selected based on in vivo efficacy tests of other protein hydrolysates in HFD-fed obese animals performed by other investigators (27–30). …”

Section: Methodsmentioning

confidence: 99%

“…Fish hydrolysates have anti-proliferative, anti-microbial and antioxidant effects (26). In particular, some protein hydrolysates have been shown to have anti-obesity and hypolipidemic effects in HFD-fed obese animals (27–30). The yellow(head) catfish or Korean bullhead ( Tachysurus fulvidraco ) is a bagrid catfish that inhabits Eastern Asia from Siberia to China, Korea, Vietnam and Laos, where it can be found in lakes and river channels.…”

Section: Introductionmentioning

confidence: 99%

Anti-obesity effects of yellow catfish protein hydrolysate on mice fed a 45% kcal high-fat diet

Kim

Kim²,

Park

et al. 2017

International Journal of Molecular Medicine

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Obesity contributes to the etiologies of a variety of comorbid conditions, such as type 2 diabetes, hypertension and cardiovascular disease. In the present study, the anti-obesity effects of yellow catfish protein hydrolysate (YPh) were observed in mice fed a 45% kcal high-fat diet (HFD) compared with those of mice treated with simvastatin. The HFD-fed control mice exhibited noticeable increase in body weight, and whole-body and abdominal fat densities, periovarian and abdominal wall-deposited fat pad weight, as well as in the levels of triglycerides (TG), blood total cholesterol (TC), low-density lipoprotein, alanine aminotransferase, aspartate aminotransferase, creatinine, blood urea nitrogen, and in the fecal TG and TC contents. However, they exhibited a decrease in serum high-density lipoprotein levels. In addition, an increase was detected in periovarian and dorsal abdominally deposited fat pad thickness, adipocyte hypertrophy, the number of steatohepatitis regions, hepatocyte hypertrophy and lipid droplet deposition-related renal tubular vacuolation degenerative lesions, along with increased hepatic lipid peroxidation and a deteriorated endogenous antioxidant defense system (glutathione, catalase and superoxide dismutase). However, all the above-mentioned obesity-related complications were dose-dependently and significantly inhibited after 84 days of thye consecutive oral administration of 125, 250 and 500 mg/kg YPh. In addition, YPh dose-dependently depleted the liver endogenous antioxidant defense system and inhibited hepatic lipid peroxidation. Overall, the effects of 250 mg/kg YPh on HFD-induced obesity and related complications were similar or more potent than those of 10 mg/kg simvastatin. These results indicate that YPh is a promising new potent medicinal ingredient for possible use in the treatment of obesity and related complications.

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“…Fish hydrolysates, which have been suggested to be advantageous protein nutritional supplements for different medical conditions (15,16), also have antioxidant, antimicrobial and antiproliferative effects (17). In particular, some protein hydrolysates have been shown to exert hypolipidemic and anti-obesity effects in high-fat diet (HFD)-fed obese animal models (18–21). The melanian snail, Semisulcospira libertina , is one of the most commonly encountered freshwater snails in Far East Asia, and has been used as an ingredient of tonic functional foods in Korea (22–24).…”

Section: Introductionmentioning

confidence: 99%

Blood glycemia-modulating effects of melanian snail protein hydrolysates in mice with type II diabetes

Choi¹,

Kim²,

Park³

et al. 2017

International Journal of Molecular Medicine

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Abstract. Freshwater animal proteins have long been used as nutrient supplements. In this study, melanian snail (Semisulcospira libertina) protein hydrolysates (MPh) were found to exert anti-diabetic and protective effects against liver and kidney damage in mice with type II diabetes adapted to a 45% kcal high-fat diet (HFD). The hypoglycemic, hepatoprotective and nephroprotective effects of MPh were analyzed after 12 weeks of the continuous oral administration of MPh at 125, 250 and 500 mg/kg. Diabetic control mice exhibited an increase in body weight, and blood glucose and insulin levels, with a decrease in serum high-density lipoprotein (HDL) levels. In addition, an increase in the regions of steatohepatitis, hepatocyte hypertrophy, and lipid droplet deposit-related renal tubular vacuolation degenerative lesions were detected, with noticeable expansion and hyperplasia of the pancreatic islets, and an increase in glucagon-and insulin-producing cells, insulin/glucagon cell ratios in the endocrine pancreas and hepatic lipid peroxidation, as well as decreased zymogen contents. Furthermore, a deterioration of the endogenous antioxidant defense system was observed, with reduced glucose utilization related hepatic glucokinase (GK) activity and an increase in hepatic gluconeogenesis-related phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6pase) activity. However, all of these diabetic complications were significantly inhibited by oral treatment with MPh in a dose-dependent manner. In addition, the marked dose-dependent inhibition of hepatic lipid peroxidation, the depletion of the liver endogenous antioxidant defense system, and changes in hepatic glucose-regulating enzyme activities were also observed. The results of this study suggest that MPh exerts potent anti-diabetic effects, along with the amelioration of related complications in mice with type II diabetes. The overall effects of MPh at a dose of 125 mg/kg on HFD-induced diabetes and related complications were similar or more potent than those of metformin (250 mg/kg).

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Corn gluten hydrolysate and capsaicin have complimentary actions on body weight reduction and lipid-related genes in diet-induced obese rats

Cited by 16 publications

References 38 publications

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

Anti-obesity effects of yellow catfish protein hydrolysate on mice fed a 45% kcal high-fat diet

Blood glycemia-modulating effects of melanian snail protein hydrolysates in mice with type II diabetes

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