Corn‐like mSiO₂@ZIF‐8 Composite Load with Curcumin for Target Cancer Drug‐Delivery System

Abstract

Dedication (Menglan Chen wrote the original manuscript and revised the manuscript. Fangxiang Song and Nian Wu conducted the material syntheses. Honghuan Luo and Xiaoqin Cai analyzed the experimental data. Yan Li proposed the project and provided guidance.)To improve the drug loading rate of mesoporous silica (mSiO 2 ), mSiO 2 nanorods were synthesized by a modified sol-gel method, then mSiO 2 @ZIF-8 nanoparticles were prepared by using mSiO 2 nanorods as the matrix. The structure of mSiO 2 and mSiO 2 @ZIF-8 were characterized. The results show that mSiO 2 @ZIF-8 nanoparticles are corn-like, with a specific surface area of 116.81 m 2 g À 1 , pore volume of 0.31 cm 3 g À 1 , and pore size of 8.43 nm. Curcumin (CUR) was used as an anti-tumor model drug in drug delivery experiments. The drug loading rate of mSiO 2 @ZIF-8 for CUR is 21.39 %. Before modification by Chitosan (CS) and folic acid (FA), the cumulative release rate of CUR is 30.27 % at pH 5.6 and 26.26 % at pH 7.4. After been target functionalized by CS and FA. At pH 5.6 and pH 7.4, the cumulative release rates are 34.21 % and 20.48 %, respectively, within 228 h after drug release in vitro. The results show that the drug delivery system has good pH responsiveness. Zeroorder, first-order, Higuchi, Hixson Crowell, and Korsmeyer

Synthesis and Application of a pH-Responsive Functional Metal–Organic Framework: In Vitro Investigation for Delivery of Oridonin in Cancer Therapy

“…In addition to the traditional advantages of ZIFs, improved structural stability, better biological compatibility, and enhanced capability for drug loading are further advantages of ZIF-8 [ 37 , 38 , 39 ]. In particular, the ZIF-8 material also has excellent pH sensitivity, which dissolves in the weak acid cell milieu of tumorous tissues, but it maintains its structural stability during neutral circumstances [ 40 , 41 , 42 ]. This feature enables the controllable and accurate release of loaded drugs at the location of tumors.…”

ZIF‐8 Based Active Wound Dressing for pH Modulation and pH‐Responsive Delivery of Curcumin and Zn2+: Effect of Acidity on the Drug Release for Antibacterial and Antioxidant Efficacy

“…In order to maximize the activity of CCM at the target site, ZIF-8 can be employed as an efficient vehicle of CCM. [8,10,[16][17][18][19] Under the normal physiological condition with neutral pH, ZIF-8 would act as a gatekeeper of CCM, keeping the CCM from being released. When CCM-holding ZIF-8 reaches the inflammatory site with an acidic condition, CCM as an anti-inflammatory agent is released with the decomposition of ZIF-8.…”