Corn Silk Induced Cyclooxygenase-2 in Murine Macrophages

Kim, Kyung A; Shin, Hong Ju; Choi, Sang Kyu; Choi, Hye‐Seon

doi:10.1271/bbb.69.1848

Cited by 10 publications

(7 citation statements)

References 30 publications

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“…Corn silk extracts contain certain bioactive compounds which show immunomodulation activity [33,48,49]. Corn silk extracts have been also found to be effective in inhibition of tumor necrosis factor-α and adhesion of leukocytes to cell surface and induction of nitric oxide synthase and cyclooxygenase in macrophages [50][51][52]. The chemically modified corn silk polysaccharides have been reported to show antioxidant and amylase inhibitory activities [14].…”

Section: Corn Leavesmentioning

confidence: 99%

Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn

Nawaz¹,

Muzaffar²,

Aslam³

et al. 2018

Corn - Production and Human Health in Changing Climate

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Corn seeds are used as a nutritional source for humans, and the stem and leaves are utilized as fodder for cattle throughout the world. Corn silk and corn cob are usually discarded as waste. This chapter highlights the nutritional as well as medicinal importance of various parts of corn plant. All parts of corn plant are good source of a variety of bioactive phytochemical compounds which possess antioxidant potential. The principal phytochemicals present in corn seed and corn silk include polyphenols, phenolic acids, flavonoids, anthocyanins, glycosides, carotenoids, and polysaccharides of biological importance, reducing compounds and some water-soluble vitamins. The presence of these phytochemicals makes corn a medicinal plant which shows various biological activities particularly the antioxidant, antimicrobial, antidiabetic, anti-obesity, antiproliferative, hepatoprotective, cardioprotective, and renal-protective activities. On the account of its high antioxidant potential, all parts of corn plant can be used for the management of oxidative stress and the treatment of various diseases.

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Section: Corn Leavesmentioning

confidence: 99%

Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn

Nawaz¹,

Muzaffar²,

Aslam³

et al. 2018

Corn - Production and Human Health in Changing Climate

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“…In the in vitro study using murine -macrophages, induction of cyclooxygenase-2 (COX-2) by NF-κB activation was detected at 2.5 µg/mL corn silk and reached the highest level at 12–25 µg/mL for 24 h incubation [ 55 ]. The expression of COX-2 positively regulated expression of iNOS and production of PGE 2 via EP2 and EP4 receptors on the surface of the macrophages.…”

Section: Pharmacological Studies For Potential Healthcarementioning

confidence: 99%

Corn Silk (Stigma Maydis) in Healthcare: A Phytochemical and Pharmacological Review

2012

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Corn silk (Stigma maydis) is an important herb used traditionally by the Chinese, and Native Americans to treat many diseases. It is also used as traditional medicine in many parts of the world such as Turkey, United States and France. Its potential antioxidant and healthcare applications as diuretic agent, in hyperglycemia reduction, as anti-depressant and anti-fatigue use have been claimed in several reports. Other uses of corn silk include teas and supplements to treat urinary related problems. The potential use is very much related to its properties and mechanism of action of its plant’s bioactive constituents such as flavonoids and terpenoids. As such, this review will cover the research findings on the potential applications of corn silk in healthcare which include its phytochemical and pharmacological activities. In addition, the botanical description and its toxicological studies are also included.

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“…It should be taken note of that ROS are actually produced by macrophages as microbial killing mechanisms. Kim et al (2005) reported that corn silk activates murine macrophages to produce cytokines and enzymes that are important in regulating normal physiological functions inflammatory response in macrophages. The data from this study likewise showed the immunostimulatory role of corn silk in macrophages from tilapia head kidney.…”

Section: Resultsmentioning

confidence: 99%

Immunostimulatory and anti-oxidative properties of corn silk from Zea mays L. in Nile tilapia, Oreochromis niloticus

Catap¹,

Jimenez²,

Tumbali³

2015

Int. J. Fish. Aquac.

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Corn silks are threads found in the maize plant (Zea mays) and traditionally used to treat urological infections and disorders. Corn silk is also known to possess nutrients and volatile compounds. However, this material is often disregarded and unused. This study therefore investigated the potential use of corn silk in aquaculture through its protective capacity in matured Nile tilapia (Oreochromis niloticus (L.) by measuring some nonspecific immune parameters (phagocytosis, production of reactive oxygen species, and plasma lysozyme level) in experimental Aeromonas hydrophila-challenged fish. The anti-oxidative property of corn silk was also investigated using paracetamol-induced hepatic toxicity in order to measure oxidative stress (malondialdehyde or MDA). Based on the results, phagocytosis was significantly higher in A. hydrophila infected fish fed with corn silk-coated feeds than in fish from the negative (PBS-injected) and positive control (Aeromonas hydrophila infected) treatments. Lysozyme level was also higher in corn silk-fed fish, but it was not significantly different from the positive control fish (A. hydrophila infected fish). Reactive oxygen species (ROS) was higher in corn silk-fed fish than the positive control fish but it was not statistically significant. MDA levels were significantly higher in paracetamol-treated fish than paracetamol-corn silk treated group. The results showed the potential immunostimulatory and antioxidant role of corn silk in Nile tilapia, but further studies are required to fully understand its mechanism of action and its full use in aquaculture.

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Corn Silk Induced Cyclooxygenase-2 in Murine Macrophages

Cited by 10 publications

References 30 publications

Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn

Phytochemical Composition: Antioxidant Potential and Biological Activities of Corn

Corn Silk (Stigma Maydis) in Healthcare: A Phytochemical and Pharmacological Review

Immunostimulatory and anti-oxidative properties of corn silk from Zea mays L. in Nile tilapia, Oreochromis niloticus

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