Corneal Biometric Features and Their Association With Axial Length in High Myopia

Jin, Guangming; Liu, Zhenzhen; Wang, Lanhua; Luo, Lixia; Liu, Yizhi

doi:10.1016/j.ajo.2021.11.031

Cited by 22 publications

(23 citation statements)

References 41 publications

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“…Corneal curvature radius was significantly larger in HM eyes, as previously reported. 22 Intra-visit reproducibilities of the angiography scans were 0.908 and 0.964 for global cpVD of eyes with and without HM, respectively.…”

Section: Resultsmentioning

confidence: 91%

Structure Function Relationships of Vessel Density and Retinal Nerve Fiber Layer Thickness in Early Glaucomatous Eyes With High Myopia

Akiyama

Saito

Shirato

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose The purpose of this study was to evaluate the structure function relationship of circumpapillary vessel density (cpVD) with visual field sensitivity (VFS) and compare its characteristics with circumpapillary retinal nerve fiber layer thickness (cpRNFLT) in early glaucomatous (EG) and normal eyes with and without high myopia (HM). Methods Seventy-five EG (mean deviation > −6 dB) and 7 normal eyes with HM (axial length [AL] >26.5 mm) and 111 EG and 11 normal eyes without HM were enrolled in this retrospective cross-sectional study. All patients underwent circumpapillary optical coherence tomography (OCT) and OCT angiography (OCTA) scanning with the Cirrus HD-6000 with AngioPlex OCTA (Carl Zeiss Meditec, Dublin, CA, USA). Structure function correlations were determined by comparing global, superior, inferior, and Garway-Heath sectoral values for cpVD and cpRNFLT with its corresponding 24-2 and 10-2 VFS of Humphrey Visual Field (HFA) analyzer. Results CpVD showed no significant correlations with AL except for the nasal sector ( P = 0.044), whereas cpRNFLT demonstrated significant positive association with AL in the global ( P = 0.024), nasal ( P = 0.020), and temporal ( P < 0.001) sectors. In HM eyes, global and sectoral cpVD significantly correlated with corresponding VFS in all 24-2/10-2 VF sectors (all P < 0.05). CpVD-VFS correlation was significantly stronger than cpRNFLT-VFS in the nasal sector of HM eyes ( P = 0.002) and temporal and inferior temporal sector of eyes without HM ( P = 0.008 and P = 0.042, respectively). Conclusions In EG eyes with HM, cpVD was less affected by AL in comparison to cpRNFLT and cpVD-VFS correlation was significant in all 24-2/10-2 VF sectors. AL-associated advantages of cpVD-VFS over cpRNFLT-VFS were observed.

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Section: Resultsmentioning

confidence: 91%

Structure Function Relationships of Vessel Density and Retinal Nerve Fiber Layer Thickness in Early Glaucomatous Eyes With High Myopia

Akiyama

Saito

Shirato

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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“…The evaluation of the relationship between AL and WTW distance with CV in the present study indicated that these parameters were significantly inversely related to CV. A look at previous studies shows that the longer the AL, as seen in high myopic patients, the lower the CV 13 ; one of the possible reasons may be the lower corneal thickness in individuals with longer AL. 14 As the AL increases, the sclera becomes more elongated and thinner; the corneal stroma is also stretched similarly and the CV decreases.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Corneal Volume and Its Associated Factors in an Elderly Population: Tehran Geriatric Eye Study

Hashemi

Valadkhan

Nabovati

et al. 2022

Cornea

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Purpose:The aim of this study was to determine the distribution of corneal volume (CV) using Pentacam and its relationship with demographic and ocular factors in an elderly population older than 60 years.Methods:The present report is a part of the Tehran Geriatric Eye Study. The sampling was performed using the multistage stratified random cluster sampling method. The preliminary ocular examinations were performed for all individuals including visual acuity measurement, objective and subjective refraction, and slit-lamp biomicroscopy. Finally, study participants underwent anterior segment imaging and ocular biometry using Pentacam AXL.Results:The mean CV was 57.92 mm3 [95% confidence interval (CI): 57.76–58.08] in the whole sample. The mean CV was 57.69 mm3 (95% CI: 57.52–57.87) after excluding diabetic patients. The mean CV was 57.79 mm3 (95% CI: 57.57–58.01) and 58.04 mm3 (95% CI: 57.83–58.26) in men and women, respectively. The mean CV was 57.96 mm3 (95% CI: 57.71–58.21), 57.84 mm3 (95% CI: 57.49–58.19), and 57.92 mm3 (95% CI: 57.7–58.13) in individuals with emmetropia, myopia, and hyperopia, respectively. The CV decreased significantly with advancing age. Moreover, the anterior chamber depth, central corneal thickness, mean keratometry, anterior corneal asphericity (Q value), and posterior corneal astigmatism were significantly directly related to CV, whereas axial length and white-to-white distance had a statistically significant inverse association with the CV.Conclusions:Aging is one of the important factors in reducing CV that should be considered. Some other topographic and biometric indices also have a significant relationship with CV.

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“…Patients seeking ophthalmological consultation, aged 18 years or older, were consecutively recruited. Participants with (1) history of an ocular surface and/or intraocular surgery or procedure; (2) presence of any ocular or systemic disease affecting the ocular surface, including eyelid pathology, corneal ectasias and dystrophies, Sjögren syndrome, or diabetes mellitus, among others; (3) prior or current history of allergic diseases potentially leading to eye rubbing (i.e., atopy, eczema, conjunctivitis); (4) history of contact lens wear; (5) high myopia (spherical equivalent < − 6.00 diopters) 12 ; and (6) ocular hypertension or glaucoma were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…(3) prior or current history of allergic diseases potentially leading to eye rubbing (i.e., atopy, eczema, conjunctivitis); (4) history of contact lens wear; (5) high myopia (spherical equivalent < − 6.00 diopters) [12]; and (6) ocular hypertension or glaucoma were excluded.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Reproducibility, Repeatability, and Correlation of Central Corneal Thickness Measurement with the Pentacam Scheimpflug System and Ultrasound Pachymetry

Macías-Rodríguez

Ruiz-Lozano

Reyes-Arena

et al. 2022

Klin Monbl Augenheilkd

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Zusammenfassung: Hintergrund: Die Bedeutung einer genauen Bestimmung der zentralen Hornhautdicke (CCT) ergibt sich unter anderem auf ihren diagnostischen und therapeutischen Implikationen bei Glaukom, Hornhautektasie, Hornhautödem, Überwachung der Endothelfunktion, und der Eignung für refraktive Chirurgie. Ziel der Studie war es, die Wiederholbarkeit, Reproduzierbarkeit, Korrelation und laterale Variationen von CCT-Messungen mittels Pentacam-HR und dem Standard-Ultraschall-A-Scan (USP) zu analysieren. Methoden: Es wurde eine Querschnittsstudie mit CCT-Messungen an gesunden Personen durchgeführt, die von drei unabhängigen Untersuchern mittels Pentacam-HR und dem USP vorgenommen wurde. Die Abweichungen von Intra-Beobachter- und Inter-Beobachter wurden mit Intraklassen-Korrelationskoeffizienten (ICCs) berechnet. Bland-Altman-Plots und 95 %-Übereinstimmungsgrenzen (95 % LoA) wurden verwendet, um die Übereinstimmung zwischen den Geräten zu bewerten. Die lineare Korrelation wurde mit dem Pearson-Koeffizienten berechnet. Ergebnisse: Dreißig Personen (60 Augen), 10 (33,3%) Männer und 20 (66,6%) Frauen mit einem Durchschnittsalter von 30,0+9,1 Jahren wurden untersucht. Es wurden keine statistischen Unterschiede in den CCT-Messungen zwischen Pentacam-HR (Bereich 500–609μm) und USP (Bereich 498–628μm) festgestellt. Es gab einen hohen Korrelationsgrad bei der Wiederholbarkeit und Reproduzierbarkeit jedes unabhängigen Geräts (ICC>0,90). Die Pearson-Korrelation zwischen 1 vs. 2, 2 vs. 3 und 3 vs. 1 Pentacam-HR-Versuchen waren 0,914, 0,958 bzw. 0,925 (p<0,001). Die entsprechenden Ergebnisse für USP waren 0,957, 0,957 bzw. 0,943 (p<0,001). Die Pentacam-HR überschätzte die CCT tendenziell um eine mittlere Differenz von 3,77 μm (95% LoA, -24,9 – 18,4). Außerdem, das rechte Auge wurde mit dem Pentacam-HR-Gerät ebenfalls überschätzt (-3,6+14,1μm), während das linke Auge unterschätzt wurde (1,3+11,1μm). Schlussfolgerung: Das Pentacam-HR-Gerät liefert zuverlässige, bedienerunabhängige CCT-Schätzungen. Das rechte Auge zeigte eine Tendenz zur Überschätzung mit der Pentacam-HR. Wir vermuten, dass ein solcher Unterschied auf eine USP-Unterschätzung in Bezug auf die Position des Patienten während der Durchführung der Studie zurückzuführen ist. In klinisch relevanten Szenarien kann die Durschführung einer dritten Messung des rechten Auges eine höhere Genauigkeit bieten. Abstract: Background/Aim: The importance of an accurate determination of central corneal thickness (CCT) relies on its diagnostic and therapeutic implications in glaucoma, corneal ectasias, corneal edema and endothelial function monitoring, refractive surgery suitability, among others. We aimed to analyze the repeatability, reproducibility, correlation, and laterality variations of CCT measurements performed with the Pentacam-HR and the standard-of-care ultrasound A-scan (USP). Methods: A cross-sectional study including CCT measurements of healthy individuals performed by three independent examiners with the Pentacam-HR and USP was conducted. Intra-observer and inter-observer variations were calculated with intra-class correlation coefficients (ICCs). Bland–Altman plots and 95% limits of agreement (95% LoA) were used to assess the agreement between devices. Linear correlation was calculated with Pearson's coefficient. Results: Thirty individuals (60 eyes), 10 (33.3%) men, and 20 (66.6%) women with a mean age of 30.0+9.1 years were studied. No statistical differences were found in CCT measurements between Pentacam-HR (range 500–609μm) and USP (range 498–628μm). There was a high degree of correlation in repeatability and reproducibility of each independent device (ICC>0.90). Pearson’s correlation between 1 vs. 2, 2 vs. 3, and 3 vs. 1 Pentacam-HR attempts were 0.914, 0.958, and 0.925, respectively (p<0.001). Corresponding results for USP were 0.957, 0.957, and 0.943 (p<0.001). The Pentacam-HR tended to overestimate CCT by a mean difference of 3.77μm (95% LoA, -24.9–18.4). Right eyes were also overestimated (-3.6+14.1μm) with the Pentacam-HR device, whereas left eyes were underestimated (1.3+11.1 μm). Conclusions: The Pentacam HR device provides reliable operator independent CCT estimates. Right eyes presented an overestimation tendency with the Pentacam HR. We suspect such difference is due to USP underestimation related to patients´ position while performing the study. In clinically relevant scenarios, performing a third measurement and cautiously measuring right eyes can provide higher accuracy.

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Corneal Biometric Features and Their Association With Axial Length in High Myopia

Cited by 22 publications

References 41 publications

Structure Function Relationships of Vessel Density and Retinal Nerve Fiber Layer Thickness in Early Glaucomatous Eyes With High Myopia

Structure Function Relationships of Vessel Density and Retinal Nerve Fiber Layer Thickness in Early Glaucomatous Eyes With High Myopia

Distribution of Corneal Volume and Its Associated Factors in an Elderly Population: Tehran Geriatric Eye Study

Reproducibility, Repeatability, and Correlation of Central Corneal Thickness Measurement with the Pentacam Scheimpflug System and Ultrasound Pachymetry

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