Corneal Collagen Cross-Linking

Chang, Clark Y.; Hersh, Peter S.

doi:10.1097/icl.0000000000000094

Cited by 20 publications

(8 citation statements)

References 34 publications

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“…[5151617] There are various explanations for thinning at the postoperative period. Toprak and Yildirim[18] reported a thinning of the cornea compared to the preoperative period with 6 months of follow-up and they suggested the potential cause as corneal tissue loss in the early postoperative period.…”

Section: Discussionmentioning

confidence: 99%

The influence of corneal collagen cross-linking on anterior chamber in keratoconus

Polat

Gündüz

Çolak

2017

Indian J Ophthalmol

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Aims:This study aimed to evaluate the effect of the corneal changes following corneal cross-linking (CXL) on the anterior chamber in keratoconus patients.Materials and Methods:Forty-five eyes of 32 patients who had been diagnosed with progressive keratoconus and had undergone CXL were included in this retrospective study. The thinnest corneal thickness of the progressive keratoconus patients included in the study was >400 μ. The preoperative (T0), postoperative 6th month (T1), and postoperative 1st year (T2) anterior chamber volume (ACV), anterior chamber angle (ACA), and anterior chamber depth (ACD) scheimpflug imaging values were obtained for each eye.Results:The mean T0 ACV value was 182.79 ± 36.68 mmwhile the T1 value was 201.25 ± 41.73 mm3 and the T2 value was 208.40 ± 42.69 mm3 with a statistically significant difference between the periods (P = 0.001). The mean T0 ACA value was 38.64° ±5.85°, increasing to 41.45° ±4.83° in the T1 and 42.10° ± 4.84° in the T2. The T0 value was significantly lower than the post-CXL values (P = 0.003). The mean ACD value was 3.73 ± 0.29 mm at the T0 and 3.82 ± 0.38 mm at the T1 and 3.84 ± 0.36 mm at the T2. The pre-CXL values were significantly lower than the post-CXL values (P = 0.001).Conclusions:The improvement of corneal parameters by CXL in keratoconus patients can have a positive effect on anterior chamber parameters as well. This effect becomes marked at the postoperative first 6-month evaluation.

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Section: Discussionmentioning

confidence: 99%

The influence of corneal collagen cross-linking on anterior chamber in keratoconus

Polat

Gündüz

Çolak

2017

Indian J Ophthalmol

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“… 60 Prospective randomized case control Up to 6 months Increased from 0.19 ± 0.26 to 0.14 ± 0.18 logMAR Kmax decreased from 53.1 ± 4.9 to 52.6 ± 5.2 Mechanical compression of cornea did not alter the results of CXL Caporossi 33 et al. 10 Up to 6 months Improved 1.66 Snellen lines Kmean decreased 2.1 ± 0.13 Increased from 431.5 to 450.6 No difference in ECD was observed Chang 46 et al. 104 eyes (66 KCN) Prospective intervention 12 months Improved 1 Snellen line Kmax decreased by 1.7 D Coskunseven 43 et al.…”

Section: Efficacy and Clinical Outcomes Of CXLmentioning

confidence: 91%

Updates on corneal collagen cross-linking: Indications, techniques and clinical outcomes

Mohammadpour

Masoumi

Mirghorbani

et al. 2017

Journal of Current Ophthalmology

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PurposeTo review the historical background and basic principles of collagen cross-linking, to bring together the data regarding the outcomes and complications of collagen cross-linking and finally to explore the efficacy and safety of new variations of this technique.MethodsA literature review was performed using PubMed and Scopus. The following keywords were used for literature search: cross linking, crosslinking, cross-linking, keratoconus, keratectasia.ResultsIn contrast to traditional treatment modalities for keratoconus (KCN), this new technique addresses the progression of the disease. Several clinical studies have been conducted to assess the efficacy of corneal collagen cross-linking (CXL) in the last decade. The results were promising as collagen cross-linking showed significant improvement in visual acuity and keratometric values. Moreover, initial results show that it is a safe procedure with few reported complications.ConclusionCXL is an emerging treatment method in ophthalmology that offers the possibility to effectively treat progressive KCN.

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“…Corneal collagen crosslinking (CXL) changed the perspective of keratoconus management because this treatment is able to slow or stop keratoconus progression 5,9,10. Since Wollensak et al published the first report of CXL in 2003, many studies have been published that showed the efficacy and safety of conventional corneal collagen CXL (C-CXL) 11–16…”

Section: Introductionmentioning

confidence: 99%

“…CXL consists of soaking the corneal stroma with riboflavin and then irradiating it with ultraviolet A (UVA) radiation 2,17. Even though the exact mechanism of action is still not completely clear, it is thought that the interaction between riboflavin and UVA results in the formation of oxygen free radicals that increase intra- and interfibrillar covalent bonds between the collagen fibrils 16,18,19…”

Section: Introductionmentioning

confidence: 99%

<p>Transepithelial accelerated versus conventional corneal collagen crosslinking in patients with keratoconus: a comparative study</p>

Madeira

Vasques

Beato

et al. 2019

OPTH

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Purpose To systematically compare the efficacy of transepithelial accelerated corneal collagen crosslinking (TE-ACXL) with conventional corneal collagen crosslinking (C-CXL) in patients with progressive keratoconus. Methods Eyes of patients with progressive keratoconus who were treated with C-CXL (3 mW/cm 2 for 30 minutes) were compared with those who underwent TE-ACXL (6 mW/cm 2 for 15 minutes). Best-corrected visual acuity (BCVA), keratometry values, corneal thickness, and topometric indexes were compared before CXL, and at 2 months, 6 months, and 12 months postoperatively. Results The study enrolled 26 eyes of which 16 had TE-ACXL and 10 had C-CXL. Both groups were comparable at baseline and 12 months in terms of BCVA ( P =0.16 and P =0.57), Kmax (maximum keratometry) ( P =0.31 and P =0.73), pachymetry ( P =0.75 and P =0.37), index of surface variance (ISV) ( P =0.45 and P =0.86), index of vertical asymmetry (IVA) ( P =0.26 and P =0.61), and index of height decentration (IHD) ( P =0.27 and P =0.86, respectively). We did not observe significant differences between preoperative and 12-month postoperative readings in within-group analysis: ΔKmax (TE-ACXL, −2.13±5.41, P =0.25 vs C-CXL, 0.78±1.65, P =0.17), Δpachymetry (TE-ACXL, 4.10±14.83, P =0.41 vs C-CXL, −8.90±22.09, P =0.24), ΔISV (TE-ACXL, −8.50±21.26, P =0.24 vs C-CXL, 3.80±12.43, P =0.36), ΔIVA (TE-ACXL, −0.12±0.31, P =0.26 vs C-CXL, 0.03±0.18, P =0.61), and ΔIHD (TE-ACXL, −0.03±0.07, P =0.18 vs C-CXL, −0.01±0.03, P =0.88). Conclusion Both TE-ACXL and C-CXL were similarly effective. Further follow-up is required to determine whether these techniques are comparable in the long-term.

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Corneal Collagen Cross-Linking

Cited by 20 publications

References 34 publications

The influence of corneal collagen cross-linking on anterior chamber in keratoconus

The influence of corneal collagen cross-linking on anterior chamber in keratoconus

Updates on corneal collagen cross-linking: Indications, techniques and clinical outcomes

<p>Transepithelial accelerated versus conventional corneal collagen crosslinking in patients with keratoconus: a comparative study</p>

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