Corneal Curvature and Thickness Development in Premature Infants

Silva, Silvana De; Parentin, Fulvio; Michieletto, Paola; Pensiero, Stefano

doi:10.3928/01913913-20100318-02

Cited by 13 publications

(15 citation statements)

References 27 publications

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“…Previous studies have shown that the CCT in full-term newborns and premature infants is significantly thicker than in adults (Autzen & Bjornstrom 1989DeSilva et al 2011). Ultrasonic pachymetry did show that the CCT of premature babies decreases significantly to the same level previously reported in fullterm newborns at 3 months of age (Autzen & Bjornstrom 1991;Kirwan et al 2005).…”

Section: Central Corneal Thickness In Fullterm Saudi Newbornssupporting

confidence: 74%

Central corneal thickness in full‐term Saudi newborns

Rushood

Zahrani

Khamis

et al. 2012

Acta Ophthalmologica

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ABSTRACT.Purpose: To establish a standard of normal central corneal thickness (CCT) in normal full-term Saudi newborn. These values could be used as a reference in the early diagnosis and control of the fairly common primary congenital glaucoma in Saudi newborns. Methods: The CCT was measured in 100 normal full-term Saudi newborns (200 eyes) during the first 6 days of the postnatal period. All measurements were carried out by one investigator using ultrasonic pachymeter DGH-1000. Results: The mean CCT of 200 eyes (right and left) was 616 ± 61 lm. The mean CCT of the right and left eyes was similar (CCTRE was 617 ± 62 lm, and mean CCTLE was 616 ± 60 lm), with no statistically significant difference (p = 0.417). The mean CCT for males was 631 ± 66 lm and for females 600 ± 50 lm. This difference was statistically significant (p = 0.01). The mean CCT decreases significantly by age [day-1: 626 ± 65 lm, day-2: 601 ± 48 lm and day-3: 574 ± 45 lm (p = 0.049)]. No correlations were found between CCT and gestational age, birth weight, birth length and head circumference. Conclusion: The average CCT in full-term Saudi newborns was found to be 616 ± 61 lm. The mean CCT in males was significantly higher than in females. There was no correlation between CCT and gestational age, birth weight, birth length and head circumference. There were borderline significant differences between CCT in 1-day-, 2-day-, and 3-day-old babies.

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Section: Central Corneal Thickness In Fullterm Saudi Newbornssupporting

confidence: 74%

Central corneal thickness in full‐term Saudi newborns

Rushood

Zahrani

Khamis

et al. 2012

Acta Ophthalmologica

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“…[1234] A progressive reduction in the intraocular pressure (IOP) of premature infants has been reported, also. [15] The purpose of this study was to evaluate the CCP and IOP differences in between premature and full-term newborns.…”

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confidence: 99%

Assessment of the central corneal thickness and intraocular pressure in premature and full-term newborns

Muslubaş

Oral

Cabi

et al. 2014

Indian J Ophthalmol

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Purpose:To assess the central corneal thickness (CCT) and intraocular pressure (IOP) in premature and full-term newborns.Materials and Methods:In this study, we evaluated measurements of CCT and IOP in 45 premature and 45 full-term newborns. IOP was determined with topical anesthesia using a Tono-Pen AVIA, applanation tonometer and a wire lid retractor in premature newborns undergoing screening for retinopathy. Full-term newborns were used as a control group. CCT was determined with a portable pachymeter after IOP measurements had been made in both groups. Because there was high correlation of CCT and IOP between right and left eyes, only the right eye data were used for further analyses.Results:The mean gestational age was 31.5 ± 2.7 weeks (ranging 25-35 weeks) and the mean age at measurement after birth was respectively 36.3 ± 0.9 weeks (ranging 33-37 weeks) in premature newborns and 38.2 ± 0.7 weeks (ranging 38-41 weeks) and 42 ± 2.2 weeks (ranging 39-46 weeks) in full-term newborns. The mean IOP was 16.2 ± 2.7 mmHg (ranging 10-22 mmHg) in premature and 16.6 ± 2.3 mmHg (ranging 10-22 mmHg) in full-term newborns. The mean CCT was found 600 ± 50 μm (ranging 515-790 μm) in the premature group and 586 ± 48 μm (ranging 475-730 μm) in the full-term group. Mean CCT was greater in premature newborns than in full-term newborns, but the difference between groups was not statistically significant (P = 0.7). Mean IOP measurement in two groups was found very similar and the difference also was not statistically significant (P = 0.27). There was no correlation between IOP and CCT, gestational age, gestational weight, age at measurement, weight at measurement neither right nor left eye in both groups in multiple regression analysis.Conclusion:We found that premature infants have slightly thicker corneas but no high IOP measurements than full-term newborns. It could be concluded that in premature at the mean gestational age of 36 weeks CCT is not different from that of full-term newborns.

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“…Kirwan [19] studied 35 premature infants and found the CCT was 691 ± 87, 648 ± 72, 605 ± 59 and 564 ± 34 µm at 30-32, 34-35, 37-38, and 39-41 weeks of PA, respectively. De Silva [20] showed a gradual decrease in the CCT from 794 ± 34 µm at 28 weeks of PA to 559 ± 13 µm at 42 weeks of PA. CCT gradually thinned with the increase of PA.…”

Section: Discussionmentioning

confidence: 93%

Ocular Growth and Refractive Status Development in Premature Infants Conceived by In Vitro Fertilization or Natural Conception

Lao¹,

Mao²,

Liu³

et al. 2019

Preprint

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Background: To evaluate the effects of IVF on the development of the refractive system in premature infants from 36 weeks to 6 months of postmenstrual age. Methods: Premature infants were examined respectively at 36 weeks, 40 weeks, 44 weeks, 48 weeks, 52 weeks and 6 months of postmenstrual age. Spherical equivalent, biometric values and central corneal thickness were measured. These parameters were compared between premature infants conceived by IVF or naturally, and the relationship between these parameters were evaluated. Results: A total of 899 premature infants were recruited. Infants born by IVF had a higher rate of oxygen therapy than which in the NC group (P = 0.04). The multiple pregnancy ratio in the IVF group was 83.4%, significantly higher than which in the NC group (p<0.001). ROP developed in 126 of the 754 infants (16.7%) in the NC group and in 35 of the 145 (24.1%) infants in the IVF group (p=0.03). With the increase of PA, the ACD (r=0.67, p<0.0001), LT (r=0.19, p<0.0001), VT (r=0.80, p<0.0001) and AL (r=0.85, p<0.0001) increased while CCT (r=-0.39, p<0.0001) thinned. The refractive state had a hyperopic shift until 44 weeks of postmenstrual age (r=0.38, p<0.0001). then the mean dioptric value continuously declined by 6 months of PA (r=-0.32, p<0.0001). There was no statistically significant difference in these parameters between the NC group and IVF group (p>0.05). The percentage of ACD (r=0.326, p<0.0001) and VT (r=0.248, p<0.0001) in AL were positively correlated with PA, while the percentage of LT (r=-0.415, p<0.0001) in AL was negatively correlated with PA. Before 44 weeks of PA, SE was positively correlated with ACD (r=0.08, p<0.01) and AL (r=0.09, p<0.01). After 44 weeks of PA, it was negatively correlated with ACD (r=-0.23, p<0.0001), VT (r=-0.35, p<0.0001) and AL (r=-0.41, p<0.01). Conclusions: The percentage of ACD and VT in AL increased, the percentage of LT in AL decreased with the early ocular development. IVF does not affect ocular growth from 36 weeks to 6 months of PA.

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Corneal Curvature and Thickness Development in Premature Infants

Cited by 13 publications

References 27 publications

Central corneal thickness in full‐term Saudi newborns

Central corneal thickness in full‐term Saudi newborns

Assessment of the central corneal thickness and intraocular pressure in premature and full-term newborns

Ocular Growth and Refractive Status Development in Premature Infants Conceived by In Vitro Fertilization or Natural Conception

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