Corneal densitometry and biomechanical properties in patients with primary congenital glaucoma

Morales-Fernández, Laura; Benito-Pascual, Blanca; Pérez-García, Pilar; Perucho-González, L.; Sáenz-Francés, F.; Santos-Bueso, E.; García-Bella, Javier; Sánchez-Jean, Rubén; García‐Feijoó, Julián; Martínez-de-la-Casa, J.M.

doi:10.1016/j.jcjo.2021.01.009

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…The present study showed that CD was significantly correlated with age, not only in the peripheral area but also in the central area; the correlation between CD and age gradually increased from the central 0-2 mm to the peripheral 6-10 mm area, but then decreased at 10-12 mm. This study provided evidence that the highest CD values were in the anterior 120 μm, and the lowest CD values were in the posterior corneal layer, which is consistent with previous studies of CD measured by Pentacam (10,15,16). The highest densitometry value obtained by SS-AS-OCT was in the midstromal layer, and the lowest was in the anterior layer (7).…”

Section: Correlations Of CD With Age and Corneal Topography Parameterssupporting

confidence: 91%

“…The Oculus Pentacam, which is designed according to the Scheimpflug principle, comprehensively analyzes the cornea and its CD by acquiring anterior segment images. CD measurement by Pentacam has been used to study different corneal diseases and surgeries (9)(10)(11)(12)(13)(14). Corneal transparency is impaired in vernal keratoconjunctivitis even when the corneal epithelium is not involved (3).…”

Section: Introductionmentioning

confidence: 99%

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Age-related changes in Scheimpflug corneal densitometry and their correlations with corneal topographic measurements in a healthy Chinese population

Zhang¹,

Hu²,

Nie³

et al. 2023

Quant Imaging Med Surg

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Background: Objective measurement of corneal densitometry (CD) values can be used to assess corneal transparency and health status, to investigate corneal diseases, and to review anterior segment surgeries.However, literature regarding the association between CD and corneal parameters in healthy adolescent and older individuals is limited. This study investigated age-related changes in Scheimpflug CD values and their correlations with age, sex, and corneal topographic parameters.Methods: This retrospective cross-sectional observational study included 347 eyes from 181 consecutive healthy Chinese participants aged between 5 and 90 years. They were divided into 9 age groups: 5-9, 10-19, 20-29, 30-39, 40-49, 50-59, 60-69, 70-79, and 80-90 years. CD and corneal topographic measurements were measured using the Oculus Pentacam. To evaluate CD, the cornea was divided into 3 layers according to depth (anterior 120 μm, central, and posterior 60 μm), and into 4 annular regions according to diameter (0-2, 2-6, 6-10, and 10-12 mm).Results: CD across different depths and regions was positively correlated with age (all P values <0.001). Of the 3 layers of corneal thickness, CD was highest in the anterior 120 μm and lowest in the posterior 60 μm (all P values <0.05). Among the 4 annular regions spanning the corneal diameter, the lowest CD values were 6-10, 2-6, and 0-2 mm at 5-29, 30-69, and 70-89 years, respectively. The highest CD values were 10-12 mm at 5-79 years, and 6-10 mm at 80-90 years (all P values <0.05). CD values of 10-12 mm in the anterior 120 μm corneal layer were significantly lower in men than in women (Z=−2.353; P=0.019). CD of 0-10 mm in each layer was not significantly different between sexes (all P values >0.05). Corneal topographic measurements, including flat-axis keratometry (K1), steep-axis keratometry (K2), and spherical aberration, were slightly positively correlated with age and CD (all P values <0.05). However, central corneal thickness (CCT) and thinnest corneal thickness (TCT), and age or CD showed no correlation (all P values >0.05).

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Section: Correlations Of CD With Age and Corneal Topography Parameterssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Age-related changes in Scheimpflug corneal densitometry and their correlations with corneal topographic measurements in a healthy Chinese population

Zhang¹,

Hu²,

Nie³

et al. 2023

Quant Imaging Med Surg

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“…This was comparable to study of Perucho-González, et al in which the mean CH was 8.51 ± 2.25 mmHg and the mean CRF was 9.85 ± 3.03 [7]. In a number of studies which were comparative studies between PCG patients and normal age matched groups, a decrease of CH and CRF in PCG patients was found as in study of Zareei, et al (CH was 8.68 ± 3.2mmHg compared to 11.87 ±2.05 mmHg in the control group with p < 0.0001 and CRF was 10.28 ± 3.3 while it was 12.90 ± 2.13 mmHg in control group with p < 0.0001) [6], Gatzioufas and his associates (CH was 9.1±1.6 mmHg in PCG patients compared to 11.4±1.2 mmHg in the normal control, p=0.01 and CRF was 7.9±1.1mmHg compared to 10.4± 1.5 mmHg in normal group, p =0.02) [14], and the study of Morales-Fernandez, et al ( CH was 8.02 ±11.35 mmHg in PCG patients vs 11.35 ± 1.42 mmHg in normal control, p < 0.001 and CRF was 9.48 ± 2.83mmHg in PCG cases vs 10.77 ±1.34 mmHg in the normal control, p < 0.001) [15]. In glaucoma patients including PCG patients, applanation tonometry is the standard tonometer to measure IOP.…”

Section: Discussionmentioning

confidence: 69%

Correlation Between Intraocular Pressure Measurements Using Applanation Tonometry and Ocular Response Analyzer (Ora) in Primary Congenital Glaucoma (Pcg) Patients

Shokier

Khalil²,

Esmael³

2022

Egyptian Journal of Clinical Ophthalmology

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Objective: This study aims to assess the degree of agreement between IOP measured using Perkins and Goldmann applanation tonometers, and both Goldmann correlated intraocular pressure (IOPg) and corneal compensated intraocular pressure (IOPcc) measured using ORA in PCG patients. Study Design: a prospective, single-center, observational study. Patients and Methods: All patients with PCG and fulfilling the inclusion criteria of the study underwent full ophthalmological examination and CCT measurement using ultrasound pachymetry. Applanation tonometer was used to measure the IOP. ORA was used to detect CH, CRF, IOPcc, and IOPg. Agreement between IOP measured using applanation tonometers, and both IOPg and IOPcc was tested using interclass correlation (ICC). Results: Forty three eyes of 28 patients were included. Twenty two were males.The mean patients age was 9.14 years. The mean IOP measured using applanation tonometry was 16.07 mmHg. The mean IOPg was 21.857 mmHg. The mean IOPcc was 24.17 mmHg. The mean difference of IOP measured by applanation and both IOPg and IOPcc was 5.78 mmHg and 8.1mmHg respectively with higher measurements by ORA. These differences were statistically significant (p =0.00). IOPg error % was statistically significantly positively correlated with CCT (p=0.009) and CRF (p=0.00) with correlation coefficient of 0.399 and 0.504 respectively. IOPcc error % was statistically significantly negatively correlated with CH (p=0.034) with correlation coefficient of -0.324. Conclusion: In the current study, a statistically significant difference between the IOP measured using applanation tonometry and ORA obtained IOP namely IOPg and IOPcc was detected with higher ORA measurements.

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“…Sixty-one studies were included after removing the studies which could not fulfill the inclusion criteria. After excluding the papers which could not provide the relevant or valid data, excluding the studies that we were unable to get original data, 27 observational studies constituted the data for analyzing [ 8 – 34 ] (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Changes in corneal biomechanics in patients with glaucoma: a systematic review and meta-analysis

2024

BMC Ophthalmol

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Introduction Corneal biomechanics has been implicated in a variety of ocular diseases. The purpose of this study was to evaluate the relationship between the glaucoma and corneal biomechanical properties, and exploring the value of corneal biomechanics in the diagnosis and follow-up of glaucoma diseases. Methods We searched studies in PubMed, EMBASE, Web of Science and clinicaltrials.gov., as of October 8, 2022. Only English studies were included, without publication time limit. We also searched the reference lists of published reviews. This meta-analysis was conducted with random-effects models, we used mean difference(MD) to evaluate the outcome, and the heterogeneity was assessed with the I2 statistic. Subgroup analyses were performed under the appearance of high heterogeneity. We used 11 items to describe the characteristics of included studies, publication bias was performed through the Egger’s test. The quality assessment were evaluated by Newcastle–Ottawa Scale(NOS) items. Results A total of 27 eligible studies were identified for data synthesis and assessment. The result of meta-analysis showed that in the comparison of included indicators, the corneal biomechanics values of glaucoma patients were statistically lower than those of normal subjects in a similar age range. The covered indicators included central corneal thickness(CCT) (MD = -8.34, 95% CI: [-11.74, -4.94]; P < 0.001), corneal hysteresis(CH)(MD = -1.54, 95% CI: [-1.88, -1.20]; P < 0.001), corneal resistance factor(CRF)( MD = -0.82, 95% CI: [-1.21, -0.44]; P < 0.001), and intraocular pressure(IOP)( corneal-compensated intraocular pressure (IOPcc): MD = 2.45, 95% CI: [1.51, 3.38]; P < 0.001); Goldmann-correlated intraocular pressure (IOPg): MD = 1.30, 95% CI: [0.41, 2.20]; P = 0.004), they all showed statistical difference. While the value of axial length(AL) did not show statistically different(MD = 0.13, 95% CI: [-0.24, 0.50]; P = 0.48). Conclusion Corneal biomechanics are associated with glaucoma. The findings can be useful for the design of glaucoma screening, treatment and prognosis.

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Corneal densitometry and biomechanical properties in patients with primary congenital glaucoma

Cited by 9 publications

References 17 publications

Age-related changes in Scheimpflug corneal densitometry and their correlations with corneal topographic measurements in a healthy Chinese population

Age-related changes in Scheimpflug corneal densitometry and their correlations with corneal topographic measurements in a healthy Chinese population

Correlation Between Intraocular Pressure Measurements Using Applanation Tonometry and Ocular Response Analyzer (Ora) in Primary Congenital Glaucoma (Pcg) Patients

Changes in corneal biomechanics in patients with glaucoma: a systematic review and meta-analysis

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