Corneal Endothelial Cell Changes Twenty Years After Penetrating Keratoplasty

Inoue, Kenji; Kimura, Chikako; Amano, Shiro; Oshika, Tetsuro; Tsuru, Tadahiko

doi:10.1016/s0021-5155(01)00485-3

Cited by 23 publications

(16 citation statements)

References 9 publications

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“…Pseudophakic bullous keratopa- significant correlation between endothelial cell loss and recipient or donor age or pre-operative diagnosis, even in the long-term period [2,6,9,32,35,48]. In one of his publications, Kus reported an ECD of 808 ± 194 cells/mm 2 with a mean thickness of 608 ± 75 µm correlated with neither thickness nor follow-up interval [6].…”

Section: Discussionmentioning

confidence: 99%

Assessment of endothelial cell density and corneal thickness in corneal grafts an average of 5 years after penetrating keratoplasty

Kettesy

Németh

Kemény-Beke

et al. 2014

Wien Klin Wochenschr

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SummaryBackground Corneal transparency is a useful indicator for corneal function. Our aim was to investigate central corneal endothelial cells and corneal thickness in transplanted corneas at an average of 5.4 years after penetrating keratoplastyPatients and methods The study involved 68 perforated keratoplasty patients with at least a 1 year followup. Post-operatively, the central corneal endothelial layer was observed using a contact specular microscope. Central endothelial cell density, corneal thickness and the coefficient of variation of endothelial size were statistically analysed.Results The post-operative follow-up time was ranging from 12 months to 23 years. Endothelial cell density (ECD) was 1,501 ± 249 cell/mm 2 . The average cell size was 673.6 ± 98.3 μm 2 , and the coefficient of variation of cell size was 0.61 ± 0.11. No difference in ECD was detected between diagnostic groups. Corneal thickness was 0.56 ± 0.06 mm. Correlation between ECD and post-operative time was not significant (r = 0.02; p = 0.85).Conclusion Our study concluded that ECD showed a higher rate of decrease after penetrating keratoplasty with no relation to pre-operative diagnosis.Keywords Endothelial cell loss · graft survival · penetrating keratoplasty · specular microscope Bestimmung der Endothelzelldichte und der Hornhautdicke in Hornhauttransplantaten circa 5 Jahre nach einer penetrierenden Keratoplastik Zusammenfassung Hintergrund Die Transparenz der Cornea ist ein nütz-licher Indikator der Funktion der Hornhaut. Das Ziel unserer Studie war es, die zentralen Endothelzellen der Cornea sowie die Dicke der Hornhaut in transplantierten Hornhäuten circa 5,4 (im Durchschnitt) Jahre nach penetrierender Keratoplastik zu untersuchen.Patienten und Methoden In die Studie wurden 68 Patienten nach perforierter Keratoplastik aufgenommen, die zumindest 1 Jahr nachuntersucht worden waren. Postoperativ wurde die zentrale Endothelschicht der Hornhautmittel seines Kontakt-Spekular Mikroskops untersucht. Die Dichte der zentralen Endothelzellen, die Dicke der Hornhaut und der Variations-Koeffizient der Größe des Endothels wurden statistisch analysiert.Ergebnisse Der Zeitpunkt der postoperativen Kontrollen variierte von 12 Monaten bis 23 Jahren. Die Endothelzelldichte (EZD) lag bei 1501 ± 249 Zelle/mm 2 . Der Mittelwert der Zellgröße war 673,6 ± 98,3 μm 2 und der Variationskoeffizient 0,61 ± 0,11. Es gab keinen Unterschied in der EZD zwischen den nach Diagnosen eingeteilten Gruppen. Die Korrelation zwischen der EZD und dem Zeitabstand zur Operation war nicht kant (r = 0,02; p = 0,85).Schlussfolgerung Unsere Studie zeigt unabhängig von der präoperativen Diagnose eine abfallende Tendenz der EZD nach penetrierender Keratoplastik.

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Section: Discussionmentioning

confidence: 99%

Assessment of endothelial cell density and corneal thickness in corneal grafts an average of 5 years after penetrating keratoplasty

Kettesy

Németh

Kemény-Beke

et al. 2014

Wien Klin Wochenschr

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“…[9][10][11]15,17,[21][22][23][24][25] Consistent with the majority of other published reports, there was no significant difference in mean ECD based on gender in this study. 5,9,16,17,26,27 With regards to the reliability and repeatability of the NAVIS endothelial analysis system, automated endothelial analysis often fails to correctly identify endothelial cell borders. 14,28 However, Kitzman et al 14 have demonstrated that after manual correction of cell borders detected by the NAVIS automated software, the endothelial density, coefficient of variation of cell area, and percentage of hexagonal cells were not different from those determined by the Corners method.…”

Section: Discussionmentioning

confidence: 99%

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Patel

McGhee

2008

Eye

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Purpose Despite the importance of a healthy endothelial layer in anterior segment surgery, the possible influence of corneal parameters on endothelial cell density (ECD) has largely been ignored in the young adult eye. This study investigated the possible associations between corneal tomographic parameters and ECD values in young adults. Methods Subjects aged 21-30 years, with normal corneas were recruited. Mean ECD, mean cell area (MCA), coefficient of variation for cell area (COVA), and proportion of hexagonal cells were derived by in vivo confocal microscopy. The Orbscan II system was used to measure corneal parameters including: thickness, horizontal corneal diameter, corneal curvature, anterior and posterior elevation, and eccentricity. Results Sixty-two subjects (42 female, 20 male) were included (mean age 25±3 years). Overall mean ECD was 3169±309 cells/mm 2 with no differences between genders. Mean percentage of hexagonality was 53 ± 5%, male subjects (55%) had a higher percentage of hexagonal cells than female subjects (51%) (P ¼ 0.02). Central corneal thickness (CCT) was 529±43 lm. Central ECD was significantly correlated with CCT (Pearson's r ¼ 0.26, P ¼ 0.04). However, horizontal corneal diameter (r ¼ 0.19, P ¼ 0.14), anterior corneal curvature (r ¼ À0.07, P ¼ 0.6), and posterior corneal curvature (r ¼ À0.07, P ¼ 0.6) were not correlated with ECD or percentage of hexagonality. There was no statistically significant association between anterior chamber depth (3.6±0.3 mm) and ECD (r ¼ 0.15, P ¼ 0.3). Conclusion Corneal thickness is related to ECD in normal young adult eye, with lower ECD values identified in thinner corneas; however, corneal diameter and corneal curvature do not have a significant correlation with ECD.

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“…When a subset of the same cohort was examined 4 to 6 years later, 80% of the grafts remained clear 16. Other series have noted mean ECDs of 852 cells/mm 2 at 20 years17 and 808 cells/mm 2 at 22 years 18. Chronic endothelial decompensation has been shown to occur when the central ECD declines to 400 to 700 cells/mm 2 19,20.…”

Section: Commentmentioning

confidence: 98%

Endothelial Cell Density to Predict Endothelial Graft Failure After Penetrating Keratoplasty

Lass¹

2010

Arch Ophthalmol

115

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Corneal Endothelial Cell Changes Twenty Years After Penetrating Keratoplasty

Cited by 23 publications

References 9 publications

Assessment of endothelial cell density and corneal thickness in corneal grafts an average of 5 years after penetrating keratoplasty

Assessment of endothelial cell density and corneal thickness in corneal grafts an average of 5 years after penetrating keratoplasty

Identifying relationships between tomography-derived corneal thickness, curvature, and diameter and in vivo confocal microscopic assessment of the endothelium in healthy corneas of young adults

Endothelial Cell Density to Predict Endothelial Graft Failure After Penetrating Keratoplasty

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