Corneal Endothelial Changes in Behçet’s Patients with Inactive Ocular Involvement

Çankaya, Cem; Cumurcu, Tongabay; Gündüz, Abuzer; Fırat, İlknur Tuncer

doi:10.1080/02713683.2018.1472285

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…When comparing BD patients with and without ocular involvement, their result showed that sub-basal nerve plexus density was significantly lower, and nerve tortuosity was significantly higher in the BD with ocular involvement group. Similar results regarding the decrease of endothelial cell density in BD patients have been reported using specular microscopy [13] and ICVM [14], as well as increased corneal thickness in the BD patients using ultrasound pachymetry [15]. The current study confirmed these results using IVCM and further expanded the knowledge by increasing the study population, by adding second control group as BD without ocular involvement and also by shining a light on the sub-basal nerve plexus tortuosity.…”

supporting

confidence: 87%

In vivo confocal microscopy for eyes with Behçet’s disease: a missing piece of the puzzle

Huang

Hung

2022

Graefes Arch Clin Exp Ophthalmol

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supporting

confidence: 87%

In vivo confocal microscopy for eyes with Behçet’s disease: a missing piece of the puzzle

Huang

Hung

2022

Graefes Arch Clin Exp Ophthalmol

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“…28 It was reported that ocular inflammation negatively affects corneal endothelial functions and increases corneal thickness, and in another study, corneal endothelial changes were even observed in Behçet’s patients without ocular involvement. 29,30 Uric acid deposition in the anterior chamber has been previously demonstrated in individuals with gout. 31 Uremic toxins can disrupt the balance between both proinflammatory and inflammatory factors and proapoptotic and apoptotic factors.…”

Section: Discussionmentioning

confidence: 93%

Corneal Endothelial Morphology and Thickness Changes in Patients with Gout

Kösekahya¹,

Atılgan²,

Atilgan³

et al. 2019

tjo

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Objectives:To investigate corneal endothelial cell density (ECD), morphology, and central corneal thickness (CCT) in patients with gout compared with healthy subjects.Materials and Methods:Fifty eyes of 50 gout patients and 50 eyes of 50 healthy subjects without gout or any other systemic disease were included in this study. After detailed ophthalmologic examination, specular microscopy (Tomey EM-4000; Tomey Corp) measurement was performed for all participants. ECD, average cell area (ACA), coefficient of variation (CV), hexagonality ratio, and CCT values were recorded.Results:Mean ECD and hexagonality ratio were lower (p=0.004 and p=0.002) and CV, ACA, and CCT values were higher (p=0.001, p=0.007, and p=0.001) in patients with gout when compared to healthy subjects. There were significant correlations between gout disease duration and CD and hexagonality ratio (p=0.019 and p=0.043) and also between uric acid value and hexagonality ratio and CCT (p=0.044 and p=0.003).Conclusion:Altered corneal endothelial function was found in patients with gout when compared to healthy subjects and the alteration increased as gout duration and uric acid value increased.

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“…17 Ozdamar et al reported increased thickness in active uveitis in Behcet's disease than inactive and control Group. 18 Cankaya et al reported decreased CD and HEX in inactive period inpatient of Behcet's disease, but no difference in CCT was seen. 19 Similarly, uveitis, but there was no difference in CCT1, whereas, in our study, we observed that there was a statistically significant difference between the Groups and patient with uveitis had increased corneal thickness (CCT) than healthy subjects.…”

Section: Discussionmentioning

confidence: 95%

Comparison of Corneal Endothelium in Patients with Uveitis and Healthy Subjects Using Specular Microscopy

Ghazanfar

Zafar²,

Ahmed³

et al. 2022

PAFMJ

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Objective: To evaluate changes in corneal endothelium in patients with anterior uveitis by using specular microscopy and compare it with the corneal endothelium of healthy subjects. Study Design: Comparative cross-sectional study. Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi Pakistan, from Jun 2018 to Jun 2019. Methodology: This study included 65 eyes of 65 patients with anterior uveitis and 65 eyes of healthy subjects. Corneal endothelium was assessed in all participants of both Groups by using Specular microscopy. Corneal endothelial markers like central corneal thickness (CCT), cell density (CD), cell minimum area, cell maximum area, the average of cell size, percent of hexagonality (HEX%), coefficient of variation (CV) were compared in both Groups. The Uveitis Group was further subdivided into active and inactive Uveitis Subgroups, and corneal endothelium markers were also compared in these Subgroups. Results: The mean endothelial cell density was 2626.0±413.0 cells/mm² in patients with uveitis, whereas cell density was 2766.0±327.0 cells/mm² in healthy subjects. The difference in endothelial cell density was statistically significant between the Groups (p=0.03). The difference between central corneal thickness, maximum cell area, average cell size and hexagonality values between Groups was also statistically significant, whereas there was no difference in terms of cell minimum area between these Groups. There was no statistically significant difference between inactive and active uveitis when corneal endothelial markers were compared between them (p>0.05). Conclusion: There was an effect of uveitis on central corneal thickness, endothelial cell density, cell size, and morphology compared to healthy subjects,......

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Corneal Endothelial Changes in Behçet’s Patients with Inactive Ocular Involvement

Abstract: Ocular attacks in our BD patients may have caused permanent changes in the corneal endothelial layer. However, these changes did not lead to corneal decompensation, but further studies are necessary to confirm these results.

Cited by 7 publications

References 23 publications

In vivo confocal microscopy for eyes with Behçet’s disease: a missing piece of the puzzle

In vivo confocal microscopy for eyes with Behçet’s disease: a missing piece of the puzzle

Corneal Endothelial Morphology and Thickness Changes in Patients with Gout

Comparison of Corneal Endothelium in Patients with Uveitis and Healthy Subjects Using Specular Microscopy

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