2013
DOI: 10.5505/respircase.2013.19483
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Corneal Opacity: A Rare Manifestation of Cystic Fibrosis

Abstract: Eye manifestations due to hypovitaminosis A was observed in the follow-up of patients with cystic fibrosis. Herein, we describe an 11-month-old infant with corneal opacity and growth retardation who was diagnosed as cystic fibrosis. To our knowledge, this is the first report in the literature of corneal opacity as a manifestation of cystic fibrosis. Furthermore, it is rare to encounter ophthalmic findings in cystic fibrosis at this age

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“…Compared with the index case, the symptoms were more severe and started earlier, which may be due to the variety of genotypes and phenotypes of CF. In 2012, an 11-month-old infant was reported with corneal opacity and FTT but no respiratory symptoms, being diagnosed as CF with vitamin A deficiency [ 7 ]. The index case had typical pulmonary CF symptoms along with corneal opacity, which resolved after pancreatic enzyme replacement and multivitamin supplementation.…”
Section: Discussionmentioning
confidence: 99%
“…Compared with the index case, the symptoms were more severe and started earlier, which may be due to the variety of genotypes and phenotypes of CF. In 2012, an 11-month-old infant was reported with corneal opacity and FTT but no respiratory symptoms, being diagnosed as CF with vitamin A deficiency [ 7 ]. The index case had typical pulmonary CF symptoms along with corneal opacity, which resolved after pancreatic enzyme replacement and multivitamin supplementation.…”
Section: Discussionmentioning
confidence: 99%