Corneal sublayer thickness in patients with pseudoexfoliation syndrome evaluated by anterior segment optical coherence tomography

Tekçe, Abdülhakim; Gülmez, Mehmet

doi:10.1007/s10792-019-01214-5

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…At present, it mainly includes excimer laser in-situ keratomileusis (LASIK), femtosecond laser-assisted LASIK (FS-LASIK), femtosecond laser stromal lens removal for small incision (SMILE), and transepithelial laser keratoplasty (T-PRK) [5]. AS-OCT can be used to measure corneal thickness, corneal epithelial thickness and corneal topographic map before corneal refractive surgery, so as to eliminate corneal thickness deficiency, keratoconus and other contraindations [6][7]. After corneal refractive surgery, AS-OCT can also be used to obtain the thickness of corneal flap, corneal epithelial thickness and corneal topography, which can timely detect some complications, such as visual regression and secondary corneal dilatation [8].…”

Section: Application Of As-oct In Corneal Refractive Surgerymentioning

confidence: 99%

Application of Anterior Segment Optical Coherence Tomography in Refractive Surgery

Jiao¹,

Wang²

2020

IJOVS

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With the development of modern medical technology, the accuracy and safety of refractive surgery in ophthalmology have been constantly improved. Many new examination methods have been applied in research and clinical practice, and anterior segment optical coherence tomography (AS-OCT) is a new non-contact non-invasive optical image diagnosis technology, which can be used to measure the biological structure of anterior segment. AS-OCT is widely used in the clinical diagnosis and treatment of corneal diseases, cataracts, glaucoma and other specialties due to its advantages of fast scanning speed, deep layer, high penetration rate and high resolution. In addition, AS-OCT can also obtain: corneal thickness, corneal epithelial thickness map, corneal topographic map, anterior chamber depth (ACD), white to white (WTW), crystal arch height (LV), Angle width of the anterior chamber, etc., so it is especially suitable for the pre-operative screening, design of operation scheme and safety evaluation after the operation of auxiliary ophthalmic refractive surgery (including corneal refractive surgery and intraocular refractive surgery). At present, corneal refractive surgery mainly includes excimer laser in-situ keratomileusis (LASIK), femtosecond laser-assisted LASIK (FS-LASIK), femtosecond laser stromal lens removal for small incision (SMILE), and transepithelial laser keratoplasty (T-PRK), and ICL implantation is the main method of intraocular refractive surgery. This article will review the clinical application of AS-OCT in corneal refractive surgery and intraocular refractive surgery, and provide reference for clinical practice.

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Section: Application Of As-oct In Corneal Refractive Surgerymentioning

confidence: 99%

Application of Anterior Segment Optical Coherence Tomography in Refractive Surgery

Jiao¹,

Wang²

2020

IJOVS

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Glaucoma

Yanoff,

Sassani

2025

Ocular Pathology

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Lack of evidence for GWAS signals of exfoliation glaucoma working via monogenic loss-of-function mutation in the nearest gene

Meyer,

Fingert,

Anderson

2024

Human Molecular Genetics

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Purpose: Exfoliation syndrome (XFS) is a systemic disease of elastin-rich tissues involving a deposition of fibrillar exfoliative material (XFM) in the anterior chamber of the eye, which can promote glaucoma. The purpose of this study was to create mice with CRISPR/Cas9-induced variations in candidate genes identified from human genome-wide association studies (GWAS) and screen them for indices of XFS. Methods: Variants predicted to be deleterious were sought in the Agpat1, Cacna1a, Loxl1, Pomp, Rbms3, Sema6a, and Tlcd5 genes of C57BL/6J mice using CRISPR/Cas9-based gene editing. Strains were phenotyped by slit-lamp, SD-OCT imaging, and fundus exams at 1–5 mos of age. Smaller cohorts of 12-mos-old mice were also studied. Results: Deleterious variants were identified in six targets; Pomp was recalcitrant to targeting. Multiple alleles of some targets were isolated, yielding 12 strains. Across all genotypes and ages, 277 mice were assessed by 902 slit-lamp exams, 928 SD-OCT exams, and 358 fundus exams. Homozygosity for Agpat1 or Cacna1a mutations led to early lethality; homozygosity for Loxl1 mutations led to pelvic organ prolapse, preventing aging. Loxl1 homozygotes exhibited a conjunctival phenotype of potential relevance to XFS. Multiple other genotype-specific phenotypes were variously identified. XFM was not observed in any mice. Conclusions: This study did not detect XFM in any of the strains. This may have been due to species-specific differences, background dependence, or insufficient aging. Alternatively, it is possible that the current candidates, selected based on proximity to GWAS signals, are not effectors acting via monogenic loss-of-function mechanisms.

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Corneal sublayer thickness in patients with pseudoexfoliation syndrome evaluated by anterior segment optical coherence tomography

Cited by 4 publications

References 23 publications

Application of Anterior Segment Optical Coherence Tomography in Refractive Surgery

Application of Anterior Segment Optical Coherence Tomography in Refractive Surgery

Glaucoma

Lack of evidence for GWAS signals of exfoliation glaucoma working via monogenic loss-of-function mutation in the nearest gene

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