Cornel iridoid glycoside improves memory ability and promotes neuronal survival in fimbria–fornix transected rats

You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis

“…Within the 10 herbs to formulate YGPs, five of which, include rehmannia glutinosa, fructus lycii, cuscutae semen, cinnamomi cortex and corni fructus, were reported to have immunomodulatory (Han et al, 2012;Yin et al, 2014), antioxidant (Chung et al, 2011;Zhang et al, 2009), anti-amnesic (Kwon et al, 2009), anti-aging (Rattanajarasroj and Unchern, 2010Yu et al, 2007) and neurotrophic activities (Kim et al, 2015;Yu et al, 2006;Zhao et al, 2010). The chemical ingredients of principle pharmacological functions identified are mainly classified into iridoid glycosides (sweroside and loganin), alkaloids (betaine, songorine, fuziline and neoline), flavonoids (hyperin and quercitrin) and organic acids (chlorogenic acid).…”

Cornel iridoid glycoside reduces infarct size measured by magnetic resonance imaging and improves neurological function after focal cerebral ischemia in rats

“…(14,32) We also found that CIG promoted neuronal survival and increased the level of the neurotrophins BDNF and nerve growth factor 28 days after surgery of bilateral fimbria-fornix transection in rats. (33) These discoveries may explain the mechanisms by which CIG decreases the cerebral infarct volume and atrophy measured by MRI and TTC staining during the chronic phase of stroke.…”

Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats

“…Cornel iridoid glycoside (CIG) is the main component extracted from Fructus Corni. Previous studies in our laboratory found that intragastric administration of CIG improved neurological function and memory ability, inhibited inflammation in brains, reduced nuclear factor kappa B (NF-κB) expression, and promoted neurogenesis and angiogenesis in rats (Li et al, 2005;Yao et al, 2009;Ya et al, 2010;Zhao et al, 2010). However, it is unknown whether CIG can treat demyelinating diseases of the CNS such as MS. Myelin basic protein (MBP)-induced EAE model in Lewis rats is characterized by weight loss and ascending paralysis followed by spontaneous recovery.…”