Cornell product in an electrocardiogram is related to reduced LV regional wall motion

Ishikawa, Joji; Yamanaka, Yuko; Watanabe, S.; Toba, Ayumi; Harada, Kazumasa

doi:10.1038/s41440-018-0164-8

Cited by 6 publications

(8 citation statements)

References 22 publications

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“…A standard 12 lead ECG was taken using a computer-based ECG device (SE-1515 DP12, EDAN),31 32 and left ventricular hypertrophy (LVH) assessed using the Cornell’s criterion, Cornell’s product and the Solokow-Lyon’s criterion 33 34…”

Section: Methodsmentioning

confidence: 99%

Cross-sectional study of the health of southern African truck drivers

et al. 2019

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ObjectivesLifestyle and working conditions of truck drivers predisposes them to risk-factors associated with communicable and non-communicable diseases, but little is known about the health status of African truck driver. This study aims to assess a cross-section of truckers in South Africa to describe their health information.SettingThe study took place across three truck-stop rest areas in the South African provinces of Free State and Gauteng.ParticipantsEligibility criteria included being males aged 18 years and older, full-time employment as a long-distance truck driver. A total of 614 male truck drivers participated; 384 (63%) were Zimbabwean and 325 (55%) completed high-school.Primary and secondary outcome measuresThe trucker survey explored demographics; working conditions; sexual, eating and sleeping behaviours; mental health status, medical history and cardiac risk-factors. Medical assessments included physical measurements, glucose and lipid measurements, ECG, carotid intima-media thickness (CIMT) and cardiac ultrasound.ResultsIn the previous month, 554 (91%) participants were sexually active; 522 (86%) had sex with a regular partner; 174 (27%) with a casual partner; 87 (14%) with a sex worker. Average time driving was 10 hours/day, 20 days/month, 302 (50%) never worked night shifts and 74 (12%) worked nights approximately four times per week. 112 (18%) experienced daytime sleepiness and 59 (10%) were ever hospitalised from an accident. Forty-seven (8%, 95% CI 5.3 to 9.5) were HIV-positive, with half taking antiretrovirals. Forty-eight (8%) truckers had some moderate depression, while 21 (4%) suffered from post-traumatic stress disorder. Reported tuberculosis, myocardial infarction, and diabetes were <3%. Prominent cardiac risk-factors included smoking (n=63, 11%), consuming alcohol (>15 drinks/week) (n=54, 9%), overweight/obesity (n=417, 69%), and hypertension (n=220, 36%,95% CI 32.1 to 39.7). ECG results showed 23 (4.9%) and 29 (5.3%) drivers had left ventricular hypertrophy using the Cornell criterion and product, respectively. CIMT measurements indicated nine (4.2%) drivers had a carotid atherosclerotic plaque.ConclusionThis first holistic assessment of health among southern African male truck drivers demonstrates substantial addressable cardiovascular risk factors, mental health issues and sexual risk behaviours.

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Section: Methodsmentioning

confidence: 99%

Cross-sectional study of the health of southern African truck drivers

et al. 2019

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“…previous studies suggest that Sokolow-Lyon voltage and Cornell product evaluate different left ventricular qualities in echocardiography [24].…”

Section: Plos Onementioning

confidence: 91%

Effect of four classes of antihypertensive drugs on cardiac repolarization heterogeneity: A double-blind rotational study

et al. 2020

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Background T-wave area dispersion (TW-Ad) is a novel electrocardiographic (ECG) repolarization marker associated with sudden cardiac death. However, limited data is available on the clinical correlates of TW-Ad. In addition, there are no previous studies on cardiovascular drug effects on TW-Ad. In this study, we examined the relation between TW-Ad and left ventricular mass. We also studied the effects of four commonly used antihypertensive drugs on TW-Ad. Methods A total of 242 moderately hypertensive males (age, 51±6 years; office systolic/diastolic blood pressure during placebo, 153±14/100±8 mmHg), participating in the GENRES study, were included. Left ventricular mass index was determined by transthoracic echocardiography. Antihypertensive four-week monotherapies (a diuretic, a beta-blocker, a calcium channel blocker, and an angiotensin receptor antagonist) were administered in a randomized rotational fashion. Four-week placebo periods preceded all monotherapies. The average value of measurements (over 1700 ECGs in total) from all available placebo periods served as a reference to which measurements during each drug period were compared. Results Lower, i.e. risk-associated TW-Ad values correlated with a higher left ventricular mass index (r = −0.14, p = 0.03). Bisoprolol, a beta-blocker, elicited a positive change in TW-Ad (p = 1.9×10 −5), but the three other drugs had no significant effect on TW-Ad.

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“…Fig. 1 Correlation coefficients between ECG and echocardiographic variables in the study by Ishikawa et al [4]. CP Cornell voltageduration product; CV Cornell voltage; SL Sokolow-Lyon voltage combination…”

Section: Compliance With Ethical Standardsmentioning

confidence: 94%

“…Moreover, the ability of the ECG to provide information on LV function is not clearly established. The cross-sectional study by Ishikawa et al expands our knowledge on the relationships between ECG LVH and echocardiographically-determined LV structural and, in particular, functional measures [4]. In a cohort of 288 consecutive outpatients with hypertension, the investigators found comparable and significant associations between left ventricular mass index (LVMI) and SL, LVMI and CP, and LVMI and Cornell voltage.…”

mentioning

confidence: 95%

“…The relevant question thus arises whether ECG LVH fully captures the risk signified by GLS and other novel echocardiographic parameters; this could result in a more cost-effective way of approaching patients with otherwise uncomplicated hypertension [2]. However, intuitively, this is unlikely to be the case as the correlations between ECG LVH and strain parameters were at best moderate, and the latter are very sensitive markers of LV function [4].…”

mentioning

confidence: 99%

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