Cornus Mas L improves Antioxidant Status in the Liver, Lung, Kidney, Testis and Brain of Ehrlich Ascites Tumor Bearing Mice

Abstract

C. mas L, is a medicinal plant that has a high level of antioxidant activity. C. mas L. is a plant that has high nutritional value and also has therapeutic properties. It grows in Asia and Europe. Especially in Turkey, it is grown in gardens for its fruit and it grows wild in northern Anatolian forests. (Kayaalp., 1996). There are numerous articles in the literature that demonstrate the antineoplastic mechanism of curcumin. C. Mas L is known to increase the rate of death of some types of cancer cells and stop the division of Tumor Cells (Peyman et al., 2014, Turhan. 1999). Earlier studies indicated that C. Mas L was a potent antioxidant and had an anticancerogenic effect. (Savikin et al., 2009). Anti-tumoral effects of plant extracts have been tested on several cancer models, one of which is the EAT model (Folkman et al., 1992, Ozaslan et al., 2011).

Application of ultrasound to the organic cornelian cherry (Cornus masL.) vinegar: Changes in antibacterial, antidiabetic, antihypertensive, and anticancer activities

“…prepared in various forms are promising in terms of antimicrobial, anti-inflammatory, antitumor, and antidiabetic activities (Alavian et al, 2014;Tiptiri-Kourpeti et al, 2019). It has also been reported that C. mas L increases the death rate of some cancer cells and stops the division of tumor cells (Yılmaz et al, 2020).…”

Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

“…Naturally, occurring antioxidant supplementation can be effectively restored redox homeostasis by neutralizing and removing excess oxidants. 30 So, administration of ASLE or ASLELN reversed the effect of EAC cells, by increasing SOD activity, and GSH content, and attenuating the EAC—mediated increase of MDA levels, demonstrating the ability of the extracts in reducing oxidative stress in tumor-bearing mice by modulating antioxidant levels. The reduction of oxidative stress in treated EST-bearing mice may be due to the antioxidant compounds content of these extracts as polyphenolic compounds and flavonoids as quercetin, that increase and have the free radical scavenging property, 31 confirming the antioxidant activity of the examined extracts especially ASLELN in the group (4).…”

“…Naturally, occurring antioxidant supplementation can be effectively restored redox homeostasis by neutralizing and removing excess oxidants . So, administration of ASLE or ASLELN reversed the effect of EAC cells, by increasing SOD activity, and GSH content, and attenuating the EACmediated increase of MDA levels, demonstrating the ability of the extracts in reducing oxidative stress in tumor-bearing mice by modulating antioxidant levels.…”

Evaluation of the antitumor and antioxidant effects of jatobá (Hymenaea courbaril) extracts / Avaliação do efeito antitumoral e antioxidante de extratos do jatobá (Hymenaea courbaril)

“…The oxidation of proteins is characterized by covalent modification in proteins, induced by different processes directly associated with progressive losses of the biochemical functions of a given protein 8 . Together, lipid peroxidation and protein oxidation cause disturbances in cellular functions that are associated with the initiation and promotion of carcinogenesis 10 .…”

“…Increased lipid peroxidation and changes in antioxidant activity of catalase, superoxide dismutase, and glutathione are usually detected in cancer patients 10 . Thus, the Ehrlich experimental model has been widely used to study the biological processes associated with tumorigenesis 11 .…”