Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis

Han, Xin; Ning, Yan; Dou, Xinyue; Wang, Yiwen; Shan, Qiyuan; Shi, Kao; Wang, Zeping; Ding, Chuan; Hao, Min; Wang, Kuilong; Peng, Mengyun; Kuang, Haodan; Yang, Qiao; Sang, Xianan; Cao, Gang

doi:10.1016/j.jpha.2023.12.017

Cited by 3 publications

(2 citation statements)

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“…Recently, some researchers demonstrated that the increased mitochondria-associated endoplasmic reticulum membrane (MAM) formation is sufficient to trigger premature cellular senescence, involving a mitochondrial ROS/p53 pathway and a partial NFκB-dependent SASP induction . The outer mitochondrial membrane (OMM) in the dynamic network of mitochondria through a special structure known as the MAM, communicates with the endoplasmic reticulum membrane. − Besides, MAM dynamic formation regulates mitochondrial dynamics, autophagy, inflammation, and apoptosis in addition to being implicated in lipid metabolism, calcium signaling, and redox signaling . Therefore, this study was designed to explore the relationship between MAM-related genes and cellular senescence-related genes in OA.…”

Section: Introductionmentioning

confidence: 99%

“… 14 The outer mitochondrial membrane (OMM) in the dynamic network of mitochondria through a special structure known as the MAM, communicates with the endoplasmic reticulum membrane. 15 − 19 Besides, MAM dynamic formation regulates mitochondrial dynamics, autophagy, inflammation, and apoptosis in addition to being implicated in lipid metabolism, calcium signaling, and redox signaling. 20 Therefore, this study was designed to explore the relationship between MAM-related genes and cellular senescence-related genes in OA.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Mitochondria-Associated Endoplasmic Reticulum Membrane-Related Genes and Cellular Senescence-Related Genes in Osteoarthritis

Li,

Wang,

Liu

et al. 2024

ACS Omega

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Background: The role of mitochondria-associated endoplasmic reticulum membrane (MAM) formation in the development of osteoarthritis (OA) is yet unclear. Methods: A mix of bioinformatics methods and in vitro experimental methodologies was used to study and corroborate the role of MAM-related genes and cellular senescence-related genes in the development of OA. The Gene Expression Omnibus database was used to obtain the microarray information that is relevant to the OA. Several bioinformatic methods were employed to carry out function enrichment analysis and protein−protein correlation analysis, build the correlation regulatory network, and investigate potential relationships between MAM-related genes and cellular senescence-related genes in OA. These methods also served to identify the MAM-related and OA-related genes (MAM-OARGs). Results: For the additional functional enrichment analysis, a total of 13 MAM-OARGs were detected. The correlation regulatory network was also created. Hub MAM-OARGs were shown to have a strong correlation with genes relevant to cellular senescence in OA. Results of in vitro experiments further demonstrated a positive correlation between MAM-OARGs (PTPN1 and ITPR1) and cellular senescence-related and OA-related genes. Conclusions: As a result, our findings can offer new insights into the investigations of MAM-related genes and cellular senescencerelated genes, which could be linked to the OA as well as brand-new potential treatment targets.

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