Coronary Artery Bypass Grafting; Vancomycin Induced Nephrotoxicity and Oxidative Stress in Patients

Abstract

ABSTRACT… Objectives:To evaluate effect of vancomycin in producing nephrotoxicity and oxidative stress in patients undergoing coronary artery bypass grafting. Study design and technique: Cross-sectional study, convenient sampling. Setting: Faisalabad institute of cardiology, Faisalabad, Pakistan. Period: 09 months. Material and Methods: Total 50 patients who were undergoing coronory artery bypass grafting were enrolled in the study based on convenience sampling after taking consent. Participants received a single dose of vancomycin (15mg/kg) before coronory artery bypass grafting and then twice a day after surgery for five days. Blood was collected at day 0, 4 and 7 and checked for serum creatinine, blood urea, blood urea nitrogen, catalase, melondialdehyde, total oxidant status and total antioxidant capacity in order to determine vancomycin induced nephrotoxicity and oxidative stress. Results: The levels of serum creatinine, blood urea and blood urea nitrogen were significantly high at day 4 and 7 as compare to day 0 with p-value 0.001.Serum catalase was significantly decreased at day 4 and 7 as compare to day 0 with p-value 0.001 while the level of serum melondialdehyde was increased significantly at day 4 and 7 in comparison with day 0 with p-value 0.01. Total antioxidant capacity was significantly decreased while total oxidant status was increased at day 4 and 7 in comparison with day 0 with p-value 0.001 each. Key words:Vancomycin, Nephrotoxicity, Oxidative Stress, Coronary Artery Bypass Grafting, Reactive Oxygen Species, Antioxidants, Satphylococcus Aureus, Malondialdehyde, Catalase.