Coronary Artery Disease in Young Women and Men With Long-Standing Insulin-dependent Diabetes

Dickinson, Stacy; Rogers, Tyson; Kasiske, B. L.; Bertog, Stefan; Tadros, George; Malik, Jamil A.; Wilson, Robert F.; Panetta, Carmelo

doi:10.1177/0003319707304579

Cited by 8 publications

(9 citation statements)

References 28 publications

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“…Multivariate predictors for severe three‐vessel CAD included prior CAD, hypertension duration, and ST‐T wave changes on ECG. It should also be noted that the prevalence of CAD in this young cohort could be underestimated as coronary angiography was not performed in patients with normal stress imaging (37.2%) (18).…”

Section: Evaluation Of Risk Factors By Specific Organ System Diseasementioning

confidence: 98%

Evaluation of Adult Kidney Transplant Candidates

Pham

et al. 2010

Seminars in Dialysis

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Important advances in immunosuppressive therapy and refinement in surgical techniques have allowed renal transplantation to become the treatment of choice for virtually all suitable candidates with end-stage renal disease. Compared to dialysis, kidney transplantation improves both patient survival and quality of life and, over time, can reduce the total cost of medical care. It must be noted, however, that although the risk of death in the first year after transplantation is <5%, not all patients qualify for the surgery because of their unacceptable risks for complications. The transplant evaluation process requires a comprehensive assessment of each patient's medical, surgical, and psychosocial histories. Selection of the suitable transplant candidate remains a challenge for transplant physicians owing, predominantly, to the presence of complex medical issues in the potential candidates and nonstandardized criteria for acceptance or rejection among transplant centers. Furthermore, with the ever-increasing disparity between donor organ supply and demand and resultant increased wait-list times, the transplant physicians must further consider the optimal management and re-evaluation of wait-list patients during the waiting period. This article describes a systematic approach for the evaluation of a potential renal transplant candidate. Various medical issues that arise during the evaluation process are discussed.

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Section: Evaluation Of Risk Factors By Specific Organ System Diseasementioning

confidence: 98%

Evaluation of Adult Kidney Transplant Candidates

Pham

et al. 2010

Seminars in Dialysis

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“…Although the Zucker diabetic fatty (ZDF) rat has been used as a model to study type 2 DM-associated restenosis [19–21], a reliable model to study the long-term effects of type 1 diabetes on ISR development is still lacking. Whereas type 1 DM represents only 5–10% of all diabetics it may be associated with severe coronary artery disease at a relatively young age as demonstrated in a selected population of type 1 diabetics eligible for kidney and/or pancreas transplantation [22]. Various rodent models of type 1 DM have been used to study the effects of diabetes on mechanically induced restenosis in mice, rats, or rabbits, in which diabetes is chemically induced using streptozotocin or alloxan and in which contradicting results were obtained [23].…”

Section: Introductionmentioning

confidence: 99%

Long‐Term Type 1 Diabetes Enhances In‐Stent Restenosis after Aortic Stenting in Diabetes‐Prone BB Rats

Onuta

Groenewegen

Klatter

et al. 2011

BioMed Research International

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Type 1 diabetic patients have increased risk of developing in-stent restenosis following endovascular stenting. Underlying pathogenetic mechanisms are not fully understood partly due to the lack of a relevant animal model to study the effect(s) of long-term autoimmune diabetes on development of in-stent restenosis. We here describe the development of in-stent restenosis in long-term (~7 months) spontaneously diabetic and age-matched, thymectomized, nondiabetic Diabetes Prone BioBreeding (BBDP) rats (n = 6-7 in each group). Diabetes was suboptimally treated with insulin and was characterized by significant hyperglycaemia, polyuria, proteinuria, and increased HbA1c levels. Stented abdominal aortas were harvested 28 days after stenting. Computerized morphometric analysis revealed significantly increased neointima formation in long-term diabetic rats compared with nondiabetic controls. In conclusion, long-term autoimmune diabetes in BBDP rats enhances in-stent restenosis. This model can be used to study the underlying pathogenetic mechanisms of diabetes-enhanced in-stent restenosis as well as to test new therapeutic modalities.

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“…Diabetes is strongly associated with vascular disease, including coronary artery disease (CAD) . In an early study by Krolewski et al., reporting long‐term outcomes in a cohort of patients with juvenile onset, insulin‐dependent diabetes followed for at least 20 yr, 35% of deaths between the ages of 30 and 55 yr were related to CAD.…”

mentioning

confidence: 99%