Coronary C-reactive protein distribution: its relation to development of atherosclerosis

Zhang, Y.X; Cliff, W. J.; Schoefl, G. I.; Higgins, Gerald A.

doi:10.1016/s0021-9150(99)00105-7

Cited by 178 publications

(112 citation statements)

References 24 publications

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“…IL-6 is a pleiotropic cytokine and central mediator of the acute-phase response and has a broad range of effects on diverse immune cells such as vascular endothelial cells, smooth muscle cells and leucocytes. 10 IL-6 11,12 and CRP [13][14][15] are also expressed in human atherosclerotic lesions.…”

Section: Introductionmentioning

confidence: 99%

Association between carotid haemodynamics and inflammation in patients with essential hypertension

et al. 2005

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Previous studies have shown that high blood pressure causes chronic inflammation. Hypertensive patients are reported to have high-circulating levels of proinflammatory cytokines such as interleukin-6 (IL-6) and high sensitive C-reactive protein (hs-CRP). The pulsatility index (PI) and resistive index (RI) are used as markers of peripheral vascular resistance. In the present study, we evaluated the relationship between carotid haemodynamics and the proinflammatory cytokines, IL-6 and hs-CRP. In all, 41 patients with essential hypertension participated. The intima-media thickness (IMT), peak systolic velocity (pVs), peak diastolic velocity (pVd) and mean velocity (mV) in the common carotid artery were measured using ultrasound Doppler flow methods, and PI [(pVsÀpVd)/mV] and RI [(pVsÀpVd)/pVs] were calculated. Serum IL-6 and hs-CRP concentrations were measured by an enzyme-linked immunosorbent assay. IMT was positively correlated with age and pulse pressure. Both PI and RI were positively correlated with pulse pressure, IL-6 and hs-CRP. A multiple regression analysis revealed that PI and RI were independently associated with hs-CRP. These results suggested that carotid haemodynamic parameters such as PI and RI are associated with atherosclerosis and inflammation in hypertensive patients.

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Section: Introductionmentioning

confidence: 99%

Association between carotid haemodynamics and inflammation in patients with essential hypertension

et al. 2005

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“…Poor glycaemic control and long-term diabetic complications are associated with endothelial dysfunction, which promotes adherence of leucocytes to the vessel walls and induces inflammatory response [3,4]. In ad-dition, to reflect the continuous inflammatory process, CRP may be directly related to the development of atherosclerosis [5]. Diabetic patients usually have increased hsCRP concentrations [6].…”

Section: Introductionmentioning

confidence: 99%

High-sensitivity C-reactive protein and impaired coronary vasoreactivity in young men with uncomplicated type 1 diabetes

et al. 2004

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Aims/hypothesis. Elevated high-sensitivity C-reactive protein (hsCRP) concentrations indicate increased risk of future coronary events. The association between hsCRP and coronary vasoreactivity has not yet been examined in type 1 diabetic subjects. Methods. We studied 18 young men who were non-smokers and who had uncomplicated type 1 diabetes. The diabetic subjects were divided into two groups, according to their median hsCRP concentration, as follows: (i) subjects with slightly elevated hsCRP (median 0.76 mg/l, range 0.47-4.73 mg/l, n=8); and (ii) subjects with low hsCRP (median 0.32 mg/l, range 0.11-0.35 mg/l, n=10). In addition we investigated 22 non-diabetic age-matched subjects (hsCRP: median 0.42 mg/l, range 0.11-1.31 mg/l). Resting myocardial blood flow and hyperaemic adenosine-stimulated flow during euglycaemic-hyperinsulinaemic clamp were determined using positron emission tomography and oxygen-15 -labelled water.Results. Diabetic subjects with slightly elevated hsCRP had significantly higher hsCRP concentrations than nondiabetic subjects (p=0.008). Resting myocardial blood flow was similar (NS) in diabetic subjects with slightly elevated hsCRP (0.79±0.19 ml·g −1 ·min −1 ) or low hsCRP (0.81±0.15 ml·g −1 ·min −1 ) and non-diabetic subjects (0.80±0.19 ml·g −1 ·min −1 ). Adenosine infusion induced a significant increase in blood flow in all study subjects (p<0.001) but was blunted in diabetic subjects with slightly elevated hsCRP (3.42±0.61 ml·g −1 ·min −1 ) when compared with diabetic subjects with low hsCRP (5.08±1.65 ml·g −1 ·min −1 , p=0.02) or non-diabetic subjects (4.51±1.36 ml·g −1 ·min −1 , p=0.04). Adenosine-stimulated flow was inversely correlated with hsCRP concentrations in all diabetic subjects (r=−0.70, p=0.001). Conclusions/interpretation. In young subjects with uncomplicated type 1 diabetes, even slightly elevated hsCRP concentrations are associated with reduced coronary vasoreactivity.Keywords Adenosine · hsCRP · Myocardial blood flow · Positron emission tomography · Type 1 diabetes High-sensitivity C-reactive protein and impaired coronary vasoreactivity in young men with uncomplicated type 1 diabetes

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“…Such a tight association between CRP levels and progression of the disease implies that CRP is not simply a sensitive marker but a direct mediator of CVD. Indeed, CRP can be detected in early lesions of atherosclerosis in humans [20] and its staining intensity correlates with disease development [21]. Moreover, CRP co-localizes with atherogenic mediators, including modified low density lipoproteins (LDL) [22,23], activated complement [24] and foam cells [20].…”

Section: The Controversial Role Of Crp In Atherosclerosismentioning

confidence: 99%

Regulated conformation changes in C-reactive protein orchestrate its role in atherogenesis

2012

Chin. Sci. Bull.

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C-reactive protein (CRP) is a prototypic human acute phase reactant composed of five identical subunits. Emerging evidence indicates that CRP is not merely a predictor of cardiovascular disease, but may also be a direct mediator. However, the diverse and sometimes contradictory activities of CRP have considerably hampered the attempts to define the exact role of CRP in atherogenesis. Here, we review the multiple layers of regulation of CRP's structure and function, highlighting how local inflammation conditions, such as the abundance of damaged cell membranes and redox homeostasis, can tip the balance of the pro-and antiinflammatory activities of CRP. We propose that the highly controlled interplay between different structural conformations of CRP underlies its intrinsic property as a fine modulator of inflammation and atherogenesis. C-reactive protein, inflammation, atherosclerosis, redox Citation:Ma X, Ji S R, Wu Y. Regulated conformation changes in C-reactive protein orchestrate its role in atherogenesis.

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Coronary C-reactive protein distribution: its relation to development of atherosclerosis

Cited by 178 publications

References 24 publications

Association between carotid haemodynamics and inflammation in patients with essential hypertension

Association between carotid haemodynamics and inflammation in patients with essential hypertension

High-sensitivity C-reactive protein and impaired coronary vasoreactivity in young men with uncomplicated type 1 diabetes

Regulated conformation changes in C-reactive protein orchestrate its role in atherogenesis

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