Coronary collateral flow: effect of drugs and perfusion pressure

Diemer, H. P.; Wichmann, Jörg; Lochner, W.

doi:10.1007/bf02023593

Cited by 17 publications

(12 citation statements)

References 24 publications

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“…The following procedure, used to abolish flow through the ischemic vascular bed, had previously been described in detail (4,6,21,24,25). A 25 % suspension of latex microspheres (25_ 5 ~ in diameter) in gum arabic (7 %) was vigorously agitated and slowly flushed into the LAD via the coronary cannula and tubing system, and the peripheral vascular bed of the LAD was embolized.…”

Section: Methodsmentioning

confidence: 99%

“…Microsphere embolization was terminated when inflow from the carotid artery had subsided to 0.5 ml/min. This method is based on several assumptions which have been extensively discussed in previous publications (4,6,21,24,25). The detail drawing in figure 1 and the resistance model in figure 2 show mierocirculalion including one collateral.…”

Section: Methodsmentioning

confidence: 99%

“…Downey and Kirk demonstrated a vascular waterfall mechanism in the coronary circulation of the beating heart (5), suggesting that if the pressure to a given coronary vessel drops below a certain critical level, blood flow *) This study was supported in part by DFG grant Er 100/3-1 ceases. Thus retrograde flow represented total collateral flow and outflow pressure of retrograde flow (PRF) could be varied without draining blood into the ischemic bed (4,6,21,24,25). However, it has not been shown if a critical pressure also exists for collateral vessels.…”

Section: Introductionmentioning

confidence: 99%

“…At this critical pressure, the resistance of the vascular bed would become very large. When retrograde flow is interrupted, pressure in the occluded coronary artery represents the pressure in the ischemic borderzone, i.e., the collateral perfusion pressure (CPP) (4,6,21,24,25). Since collaterals are vessels with a minireal density of smooth muscle, they could be considered "collapsible tubes", and a waterfall phenomenon could also apply to the collateral vasculature.…”

Section: Introductionmentioning

confidence: 99%

“…However, it has not been shown if a critical pressure also exists for collateral vessels. Collateral resistance can thus be determined from the pressure across the collateral bed and retrograde flow (4,6,21,24,25). Thus collateral blood flow would not depend on PPC in the ischemic bed, since: Collateral Blood Flow = (CPP-Surrounding Tissue Pressure)/Collateral Resistance (17).…”

Section: Introductionmentioning

confidence: 99%

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Influence of the ischemic coronary bed on collateral blood flow

et al. 1982

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The purpose of this study was to determine the influence of the resistance of the terminal vascular bed of an occluded coronary artery on collateral blood flow and collateral resistance. In 6 anesthetized dogs, left anterior descending coronary artery (LAD) was ligated, cannulated, and the terminal vascular bed was occluded by latex microspheres (diameter: 25 mu). Retrograde flow was measured using a new technique, which allowed control of outflow pressure of retrograde flow (PRF) at the LAD cannula. When retrograde flow was interrupted, pressure in the occluded vessel represented collateral perfusion pressure (CPP) within the border zone of the ischemic vessel. Collateral resistance was determined dividing the pressure difference across the collateral bed (CPP-PRF) by retrograde flow. Variation of PRF was used as a model for changes in resistance of the ischemic bed. Retrograde flow fell when PRF was increased from 11.0 +/- 3.0 ml X min-1 X 100 g-1 (PRF = 0) to 8.3 +/- 2.4 (p less than 0.01)(PRF = 24.6 +/- 6 mm Hg). For the same PRF range, collateral resistance fell from 9.68 +/- 2.96 to 8.30 +/- 2.50 mm Hg X ml-1 X min X 100 g (p less than 0.01). These results indicate that the vascular resistance of the terminal ischemic bed may considerably influence collateral blood flow and resistance.

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