Coronavirus Disease 2019 – Dengue Fever Coinfection: A Case Report

Kamarany, Mohammed Amood Al; Majam, Ahmed; Suhail, Khaled; Zuhairy, Abdullah; Alabsi, Elham

doi:10.9734/ijpr/2023/v12i4234

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…The study included all patients that were admitted and treated in isolation department and patients were treated at home. Note : The area is vectorborne diseases endemic , therefore the malarai and dengue were diagnosed to manage the coinfection [18][19][20][21][22][23][24][25] .…”

Section: Study Areamentioning

confidence: 99%

Pharmacological and Therapeutic Features of COVID - 19 Infection in Hodeidah, Yemen

AL-Kamarany,

Alkadi,

Almadani

et al. 2024

JAMPS

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Background: The symptoms and signs of coronavirus diseases 2019 (COVID-19) present at illness onset vary, but over the course of the disease, most persons with COVID-19 will experience the following: fever , cough, fatigue, anorexia, shortness of breath, hypoxia, sputum production, and myalgia . During the first year (2020), there was no effective cure for COVID-19 infection and the most common treatment for patients was supportive therapy. Ministry of Public Health and Population in Yemen presented national guideline that is extracted from other countries and World Health Organization (WHO). Objective: Therefore, in this research, we discuss the pharmacological and therapeutic approaches for management of COVID-19 during its early period of rampage, using availability of medicines in Yemeni local pharmaceutical marketing. On the other hand, the efficacy of therapeutic was monitored. Methodology: 505 patients with COVID-19 from Hodeidah showed that respiratory infection illness can range from mild to critical. Mild to moderate was 386 case (78.93 %) , severe cases (dyspnea, hypoxia, or lung involvement on imaging) was 73 cases (15.13 %) and critical cases (respiratory failure, shock, or multiorgan system dysfunction) was 28 cases (5.93 %). The major criteria for cases admission namely clinical examination, case definition, clinical investigation, radiological finding, hematological finding , and molecular biology assay namely real – time - polymerase chain reaction (RT- PCR). The pharmacological and therapeutic properties of supportive therapy of COVID - 19 included " antipyretic agent , analgesic agent, glucocortocoid (dexamethasone), anticoagulant agent (enoxaparin) , bronchodilator agent (sulbtamol), anti-cough (acetylcysteine), antibiotics broad spectrum to treat the secondary infection namely azithromycin , ceftriaxone , piperacillin and tazobactam , vancomycine , meropenam , and moxifloxacine). In addition, oxygen therapy is the major treatment that used in treatment of severe and critical cases. Also , vitamins (C and D3) and mineral namely zinc were pecribed and proton pump inhibitor (PPI) (pantaprazol) , anti-emetic (ondansetron). Fluid therapy namely ringer lactate or normal saline are used in management of COVID – 19. Results: The results showed that the age of the patients included in this study between 3- 92 years with 1.5 : 2.0 male: female. 49 patients were admitted in COVID – 19 isolation department of CTMID. 25/49 cases (54.34% ) were recovered with national guideline , the average of RR pre - treatment was 30 ± 5 breath / minute and reduced to 23 ± 2 breath / minute post – treatment with significantly statistically different (p < 0.05) . On the other hand, the clinical symptoms namely difficult in breathing, co[a]ugh , fever , and headache reduced to absent absolutely (100 %) . In addition, the results showed that the average of WBC pre - treatment was 20 ± 4 (×10 9/L) and reduced to 7 ± 2 (×10 9/L) post – treatment with significantly statistically different (p < 0.05). Also, lymphocytes decreased with COVID -19 infection to 2 % with average (10±5%) and improved post - treatment to 20 %. In addition, neutrophil increased to 95 % with average (80±15%) and improved to 70 % post-treatment. the average of WBC pre - treatment was 20 ± 4 (×10 9/L) and reduced to 7 ± 2 (×10 9/L) post-treatment with significantly statistically different (p < 0.05). The outcome finding of management that 386 cases (76.43 %) of mild and 54 cases (11.04 %) of severe were recovered at home, 19 cases (3.88 %) of severe and 6 cases (1.22 %) of critical were recovered at isolation center. On the other hand, 1 case of severe and 21 cases of critical COVID [were] died. Conclusion: In spite of lack of specific antiviral drugs, the approach of pharmacology and therapeutics had good impact at level of mild to moderate cases, [and severe case] while severe and crititical cases needs to develop at level critical case] more intensive care (ICU) including mechanical venitlation procedure.

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Section: Study Areamentioning

confidence: 99%

Pharmacological and Therapeutic Features of COVID - 19 Infection in Hodeidah, Yemen

AL-Kamarany,

Alkadi,

Almadani

et al. 2024

JAMPS

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“…Center of Tropical Medicine and Infectious Diseases (CTMID), Al Thawara Public Hospital Authority, Hodeidah, Yemen from 1 st June to 31 st December 2020. Note : The area is endemic of vectorborne diseases (VBDs) such as the malaria, dengue and vaccinepreventable diseases (VBDs) that cause other infection (coinfection) to effect on hematological parametric [8][9][10][11][12].…”

Section: Study Areamentioning

confidence: 99%

Hematological and Coagulation Features of COVID-19 Patients in Hodeidah, Yemen

Balkam,

Al-Kamarany

2023

IJPR

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Background: The blood parameters are very important markers for the progression of COVID-19 infection and predicator for severity. Objectives: Therefore, the study aimed to describe the hematological and coagulation features of coronavirus disease 2019 (COVID-19) infection. Methodology: The descriptive study (a case series) included 49 patients that were diagnosed clinically and confirmed by the real time – polymerase chain reaction (RT-PCR) with COVID-19. The patients were extremely debilitated, the severe and critical cases were treated in the isolation center (inpatient). Hematological parameters and coagulation tests were measured based on standards methods. Results: The results revealed that 85.7 % of the patients had pretreatment leukocytosis with average count of WBC 15.24 ± 6.18 (×10 9/L). On the other hand, the WBC count, which had reached a peak of 34 (×10 9/L) as maximum value. Also, the reduction of the lymphocytes (lymphopenia) associated with COVID -19 infection was up to 1 % with average (8.75 ± 6.92 %). The neutrophils increased (neutrophilia) to 98 % with average (87.40±8.45%). In addition, the thrombocytopenia was reported in 2/49 cases (4.08 %), and low in hemoglobin (severe anemia) was reported in 5/49 case (10.20 %). The coagulation tests revealed increased in D-dimer levels (p < 0.05) in severe and critical patients. On the other hand, the results showed normal in prothrombin time (PT) and partial thromboplastin time (PTT) (p > 0.05). Conclusion: The study concluded that decrease in lymphocytes (lymphopenia), increase in NLR in patients with severe COVID-19 infection and increase in D-dimer are good predicator for progressive and severity illness in COVID-19 infection.

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Coronavirus Disease 2019 – Dengue Fever Coinfection: A Case Report

Cited by 2 publications

References 17 publications

Pharmacological and Therapeutic Features of COVID - 19 Infection in Hodeidah, Yemen

Pharmacological and Therapeutic Features of COVID - 19 Infection in Hodeidah, Yemen

Hematological and Coagulation Features of COVID-19 Patients in Hodeidah, Yemen

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