Coronin 2B regulates dendrite outgrowth by modulating actin dynamics

Chen, Yuewen; Xu, Jinying; Zhang, Yulin; Ma, Shuangshuang; Yi, Wanying; Liu, Saijuan; Yu, Xiaojun; Wang, Jiali; Chen, Yu

doi:10.1002/1873-3468.13886

Cited by 10 publications

(10 citation statements)

References 29 publications

(36 reference statements)

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“…Pallium development is strongly correlated with the presence of brain-specific SEs. We identified a brain-specific SE in the CORO2B gene, which is important in neuronal migration in mice, and shows strong brainspecific expression (68,78). Neuronal migration during cortical development is essential for maintaining normal brain function and structure.…”

Section: Discussionmentioning

confidence: 99%

A body map of super-enhancers and their function in pig

Yang,

Li,

Meng

et al. 2023

Front. Vet. Sci.

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IntroductionSuper-enhancers (SEs) are clusters of enhancers that act synergistically to drive the high-level expression of genes involved in cell identity and function. Although SEs have been extensively investigated in humans and mice, they have not been well characterized in pigs.MethodsHere, we identified 42,380 SEs in 14 pig tissues using chromatin immunoprecipitation sequencing, and statistics of its overall situation, studied the composition and characteristics of SE, and explored the influence of SEs characteristics on gene expression.ResultsWe observed that approximately 40% of normal enhancers (NEs) form SEs. Compared to NEs, we found that SEs were more likely to be enriched with an activated enhancer and show activated functions. Interestingly, SEs showed X chromosome depletion and short interspersed nuclear element enrichment, implying that SEs play an important role in sex traits and repeat evolution. Additionally, SE-associated genes exhibited higher expression levels and stronger conservation than NE-associated genes. However, genes with the largest SEs had higher expression levels than those with the smallest SEs, indicating that SE size may influence gene expression. Moreover, we observed a negative correlation between SE gene distance and gene expression, indicating that the proximity of SEs can affect gene activity. Gene ontology enrichment and motif analysis revealed that SEs have strong tissue-specific activity. For example, the CORO2B gene with a brain-specific SE shows strong brain-specific expression, and the phenylalanine hydroxylase gene with liver-specific SEs shows strong liver-specific expression.DiscussionIn this study, we illustrated a body map of SEs and explored their functions in pigs, providing information on the composition and tissue-specific patterns of SEs. This study can serve as a valuable resource of gene regulatory and comparative analyses to the scientific community and provides a theoretical reference for genetic control mechanisms of important traits in pigs.

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Section: Discussionmentioning

confidence: 99%

A body map of super-enhancers and their function in pig

Yang,

Li,

Meng

et al. 2023

Front. Vet. Sci.

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“…The most significant genes within the haplotype block were located in the intronic regions of the Itga11 gene. Interestingly, Coro2b, which encodes Coronin-2b, a regulator of actin dynamics, and Fem1b, which encodes the death receptor-associated ankyrin repeat protein FEM1b with characterized roles in mediating cell stress [26][27][28][29], are adjacent to Itga11 on mouse chromosome 9. Notably, rs29586321, which is a SNP located in the 5'UTR of Fem1b, was also among the SNPs that were significantly associated with AIPD.…”

Section: Discussionmentioning

confidence: 99%

“…These data are consistent with our findings of fewer CD3 + T cells and TRM cells in Itga11 −/− mice compared to WT mice following AIPD induction. Because TRM cells likely contribute to site‐specific disease memory in psoriasis and persist in resolved lesions [26], further elucidation of the impact of Itga11 during the chronic phase of the disease warrants more investigation.…”

Section: Discussionmentioning

confidence: 99%

“…We recognize that Itga11 may also affect the chronic phase, notably due to its impact on ECM organization. Future studies using chronic models of psoriasis [26] might be performed to address these issues. Further studies, including a direct comparison of fibroblasts derived from Itga11 −/− and WT mice, will be needed for an in‐depth understanding of the molecular mechanisms via which Itga11 deficiency contributes to the observed inflammation‐mediated disruption of the ECM.…”

Section: Discussionmentioning

confidence: 99%

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Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis

Bieber

Bezdek

Gupta

et al. 2023

The Journal of Pathology

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Psoriasis is a chronic inflammatory skin condition. Repeated epicutaneous application of Aldara® (imiquimod) cream results in psoriasiform dermatitis in mice. The Aldara®‐induced psoriasiform dermatitis (AIPD) mouse model has been used to examine the pathogenesis of psoriasis. Here, we used a forward genetics approach in which we compared AIPD that developed in 13 different inbred mouse strains to identify genes and pathways that modulated disease severity. Among our primary results, we found that the severity of AIPD differed substantially between different strains of inbred mice and that these variations were associated with polymorphisms in Itga11. The Itga11 gene encodes the integrin α11 subunit that heterodimerizes with the integrin β1 subunit to form integrin α11β1. Less information is available about the function of ITGA11 in skin inflammation; however, a role in the regulation of cutaneous wound healing, specifically the development of dermal fibrosis, has been described. Experiments performed with Itga11 gene‐deleted (Itga11−/−) mice revealed that the integrin α11 subunit contributes substantially to the clinical phenotype as well as the histopathological and molecular findings associated with skin inflammation characteristic of AIPD. Although the skin transcriptomes of Itga11−/− and WT mice do not differ from one another under physiological conditions, distinct transcriptomes emerge in these strains in response to the induction of AIPD. Most of the differentially expressed genes contributed to extracellular matrix organization, immune system, and metabolism of lipids pathways. Consistent with these findings, we detected a reduced number of fibroblasts and inflammatory cells, including macrophages, T cells, and tissue‐resident memory T cells in skin samples from Itga11−/− mice in response to AIPD induction. Collectively, our results reveal that Itga11 plays a critical role in promoting skin inflammation in AIPD and thus might be targeted for the development of novel therapeutics for psoriasiform skin conditions. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

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“…, 2017 ), less information is available on the function of Type II Coronins, including CORO2A and CORO2B. Nevertheless, CORO2B has been implicated in the regulation of actin polymerization to facilitate dendrite outgrowth ( Chen et al. , 2020 ), and CORO2A has been linked to actin regulation and subsequent control of a variety of cellular pathways, from migration to control of inflammatory response genes ( Marshall et al.…”

Section: Discussionmentioning

confidence: 99%