Corpus callosum atrophy associated with the degree of cognitive decline in patients with Alzheimer's dementia or mild cognitive impairment: A meta-analysis of the region of interest structural imaging studies

Wang, Xudong; Ren, Ming; Zhu, Minwei; Gao, Wenpeng; Zhang, Jun; Shen, Hong; Lin, Zhiguo; Feng, Honglin; Zhao, Chang-Jiu; Gao, Keming

doi:10.1016/j.jpsychires.2015.02.005

Cited by 27 publications

(10 citation statements)

References 89 publications

(163 reference statements)

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“…Exploring the etiologies of BPSD can be challenging, as medications, environmental triggers, and unmet needs [ 13 ] are regarded to be contributing factors in addition to preexisting brain structural changes relevant to the subtype and severity of dementia [ 6 , 7 ]. The corpus callosum (CC) has been associated with numerous neuropsychiatric features among demented patients, as it is involved in the control of mood [ 14 ], cognition [ 15 , 16 ], and behavior [ 17 ]. It is the largest white matter structure in the human brain, and is comprised of widespread homotopic and heterotopic connections according to the anatomical portion.…”

Section: Introductionmentioning

confidence: 99%

Comparison of neuropsychiatric symptoms and diffusion tensor imaging correlates among patients with subcortical ischemic vascular disease and Alzheimer’s disease

Huang

Hsu

et al. 2017

BMC Neurol

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BackgroundThe causes of behavioral and psychological symptoms of dementia (BPSD) vary according to the dementia subtype and associated neuropathology. The present study aimed to (i) compare BPSD between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer’s disease (AD) across stages, and (ii) explore the associations with diffusion tensor imaging (DTI) in the corpus callosum (CC) and other major fibers.MethodsTwenty-four patients with SIVD and 32 with AD were recruited. Four domains of the Neuropsychiatric Inventory (NPI) (hyperactivity, psychosis, affective, and apathy) and two DTI parameters [fractional anisotropy (FA) and mean diffusivity (MD)] within the genu, body (BCC), and splenium (SCC) of the CC and other major fibers were assessed.ResultsOverall, the patients with clinical dementia rating (CDR) 1 ~ 2 had higher scores in apathy domain than those with CDR0.5. Among those with CDR1 ~ 2, SIVD had higher scores in apathy domain than AD. MD values in the BCC/SCC were positively correlated with total NPI score and psychosis, hyperactivity, and apathy domains. FA values in the SCC were inversely correlated with total NPI score and psychosis domain. The correlations were modified by age, the CASI, and CDR scores. Stepwise linear regression models suggested that FA value within the left superior longitudinal fasciculus predicted the hyperactivity domain. MD value within the SCC/left uncinate fasciculus and FA value within the GCC/left forceps major predicted the psychosis domain. MD value within the right superior longitudinal fasciculus and CDR predicted the apathy domain. Further analysis suggested distinct patterns of regression models between SIVD and AD patients.ConclusionWhite matter integrity within the BCC/SCC had associations with multi-domains of BPSD. Our study also identified important roles of regions other than the CC to individual domain of BPSD, including the left superior longitudinal fasciculus to the hyperactivity domain, the left uncinate fasciculus/forceps major to the psychosis domain, and the right superior longitudinal fasciculus to the apathy domain. The neuronal substrates in predicting BPSD were different between SIVD and AD patients. Of note, apathy, which was more profound in SIVD, was associated with corresponding fiber disconnection in line with dementia severity and global cognition decline.Electronic supplementary materialThe online version of this article (doi:10.1186/s12883-017-0911-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Comparison of neuropsychiatric symptoms and diffusion tensor imaging correlates among patients with subcortical ischemic vascular disease and Alzheimer’s disease

Huang

Hsu

et al. 2017

BMC Neurol

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“…Furthermore, the slight prevalence of inter-hemispheric connections in the coatrophy network of AD (see Figure S5 in Supplementary Material) is consistent with the deterioration of white matter bundles in AD, in particular concerning the corpus callosum ( 133 – 137 ). Callosal atrophy has been associated with cognitive decline rate as well as to disease progression ( 138 , 139 ).…”

Section: Discussionmentioning

confidence: 99%

The Pathoconnectivity Profile of Alzheimer’s Disease: A Morphometric Coalteration Network Analysis

et al. 2018

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Gray matter alterations are typical features of brain disorders. However, they do not impact on the brain randomly. Indeed, it has been suggested that neuropathological processes can selectively affect certain assemblies of neurons, which typically are at the center of crucial functional networks. Because of their topological centrality, these areas form a core set that is more likely to be affected by neuropathological processes. In order to identify and study the pattern formed by brain alterations in patients’ with Alzheimer’s disease (AD), we devised an innovative meta-analytic method for analyzing voxel-based morphometry data. This methodology enabled us to discover that in AD gray matter alterations do not occur randomly across the brain but, on the contrary, follow identifiable patterns of distribution. This alteration pattern exhibits a network-like structure composed of coaltered areas that can be defined as coatrophy network. Within the coatrophy network of AD, we were able to further identify a core subnetwork of coaltered areas that includes the left hippocampus, left and right amygdalae, right parahippocampal gyrus, and right temporal inferior gyrus. In virtue of their network centrality, these brain areas can be thought of as pathoconnectivity hubs.

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“…O corpo caloso é a principal comissura inter-hemisférica e apresenta alteração já na fase prodrômica da doença 34,35 . Fabri et al 36 demonstraram que propriedades estruturais do corpo caloso apresentam importância central para o desenvolvimento e a extensão das assimetrias hemisféricas funcionais.…”

Section: Discussionunclassified

Avaliação de assimetria hemisférica funcional em pacientes com doença de Alzheimer

Silva¹,

Yang²,

Sena³

2019

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Introdução: as assimetrias cerebrais constituem aspectos fundamentais para a organização funcional e o processamento cognitivo. Estudos prévios têm reportado que alterações no padrão de assimetria hemisférica existentes em algumas patologias reduzem a eficiência no processamento de informação. Objetivos: avaliar a assimetria hemisférica funcional a partir de padrões de homofilia e heterofilia; analisar a assimetria da conectividade funcional de redes dinâmicas em portadores de Alzheimer. Metodologia: foram construídas redes funcionais dinâmicas do córtex cerebral de pacientes com diferentes níveis de Alzheimer (muito leve, leve e moderado a grave) e do grupo de controle a partir de EEG (19 eletrodos, Sistema 10-20). Tais redes foram geradas a partir do método de associação sincronização por motifs e representadas através de grafos variantes no tempo e de redes estáticas agregadas. Essas redes foram avaliadas por meio de índices de assimetria e conectividade. Resultados: os resultados mostram uma tendência à redução da homofilia com a progressão da enfermidade, quando se compara ao controle, além de um leve aumento do índice para o último estágio, se comparado aos estágios iniciais da doença. A assimetria para a conectividade funcional, por sua vez, mostrou uma propensão a maior conectividade para o hemisfério direito, salvo para o estágio moderado a grave. Conclusão: embora os resultados não tenham apresentado diferenças significativas, eles indicam tendências de alteração no padrão de homofilia e na assimetria da conectividade funcional em redes funcionais dinâmicas de pacientes com Alzheimer.

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Corpus callosum atrophy associated with the degree of cognitive decline in patients with Alzheimer's dementia or mild cognitive impairment: A meta-analysis of the region of interest structural imaging studies

Cited by 27 publications

References 89 publications

Comparison of neuropsychiatric symptoms and diffusion tensor imaging correlates among patients with subcortical ischemic vascular disease and Alzheimer’s disease

Comparison of neuropsychiatric symptoms and diffusion tensor imaging correlates among patients with subcortical ischemic vascular disease and Alzheimer’s disease

The Pathoconnectivity Profile of Alzheimer’s Disease: A Morphometric Coalteration Network Analysis

Avaliação de assimetria hemisférica funcional em pacientes com doença de Alzheimer

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