Corpus luteum Regression Induced by Prostaglandin F2α in Microminipigs During the Normal Estrous Cycle

Noguchi, Michiko; Hirata, Masaya; Kawaguchi, Hiroaki; Tanimoto, Akihide

doi:10.21873/invivo.11175

Cited by 5 publications

(1 citation statement)

References 29 publications

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“…They also show the same estrous characteristics as standard pigs and other miniature pig strains, with similar gonadotropin and ovarian steroid profiles throughout the estrous cycle (21). Estrogen treatment can be used to induce pseudopregnancy in microminipig females, and subsequent prostaglandin treatment allows synchronization of estrus (22,23). Male microminipigs reach sexual maturity at around 4.5 months of age as shown by analysis of testicular tissues and epididymides, and by growth of accessory gonadal tissue (24).…”

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confidence: 99%

Sperm Characteristics in Microminipigs

Kawarasaki¹,

Enya²,

Otake³

2022

In Vivo

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Background/Aim: The microminipig is a relatively new type of mini pig; microminipigs weigh about 10 kg at 6 months of age and are expected to be of use in drug discovery research and safety tests. Herein, we analyzed the characteristics of ejaculated sperm from microminipigs. Materials and Methods: Sperm parameters such as microstructure and sensitivity to cold shock were investigated using optical or scanning electron microscopy. Results: Ejaculate volumes and total numbers of sperm were lower than in standard pig strains, but were proportional to body weight. Ejaculation time, pH of the ejaculate, sperm motility and morphology, and sensitivity to cold shock were similar to those of standard pig strains. Conclusion: Herein, we provide the first characterization of the ejaculates of microminipigs and demonstrate that this type of pig will be useful not only in medical research, but also in investigations into sperm preservation in different pig breeds.

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confidence: 99%

Sperm Characteristics in Microminipigs

Kawarasaki¹,

Enya²,

Otake³

2022

In Vivo

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Eicosanoids: Atherosclerosis and cardiometabolic health

Piper

Garelnabi

2020

Journal of Clinical & Translational Endocrinology

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A single cell atlas of the cycling murine ovary

Morris

Meinsohn

Chauvin

et al. 2022

Preprint

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The estrous cycle is regulated by rhythmic endocrine interactions of the nervous and reproductive systems, which coordinate the hormonal and ovulatory functions of the ovary. Folliculogenesis and follicle progression require the orchestrated response of a variety of cell types to allow the maturation of the follicle and its sequela, ovulation, corpus luteum (CL) formation, and ovulatory wound repair. Little is known about the cell state dynamics of the ovary during the estrous cycle, and the paracrine factors that help coordinate this process. Herein we used single-cell RNA sequencing technology to evaluate the transcriptome of over 34,000 cells of the adult mouse ovary and describe the transcriptional changes that occur across the normal estrous cycle and other reproductive states to build a comprehensive dynamic atlas of murine ovarian cell types and states.

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Corpus luteum Regression Induced by Prostaglandin F2α in Microminipigs During the Normal Estrous Cycle

Abstract: Abstract. Induction of corpus luteum regression andsubsequent estrus using prostaglandin F 2α (PGF 2α

Cited by 5 publications

References 29 publications

Sperm Characteristics in Microminipigs

Sperm Characteristics in Microminipigs

Eicosanoids: Atherosclerosis and cardiometabolic health

A single cell atlas of the cycling murine ovary

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