CORR Insights®: Survival, Recurrence, and Function After Epiphyseal Preservation and Allograft Reconstruction in Osteosarcoma of the Knee

Fabbri, Nicola

doi:10.1007/s11999-014-4121-9

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Patients with OS tend to suffer from early metastasis and lung metastasis (Hegyi et al, ; Moore & Luu, ; Rasalkar et al, ), which consequently leads to poor prognosis. Although researchers have dedicated great perseverance to improving the treatment for OS, the overall survival remains gloomy (Bielack et al, ; Fabbri, ; Jaffe, ; Luetke et al, ). Therefore, it's an urgency to further study the underlying mechanism of OS progression to improve the status quo.…”

Section: Discussionmentioning

confidence: 99%

“…Osteosarcoma (OS), the most common primary malignant bone tumor with the highest morbidity among adolescents, is often characterized by early metastasis and lung metastasis (Hegyi et al, ; Moore & Luu, ; Rasalkar, Chu, Paunipagar, Cheng, & Li, ). In spite of existing achievements in treatment approaches, overall survival among patients with OS remains unsatisfactory (Bielack et al, ; Fabbri, ; Jaffe, ; Luetke, Meyers, Lewis, & Juergens, ). Hence, better illustration on the molecular mechanism behind OS is of necessity (Lindsey, Markel, & Kleinerman, ).…”

Section: Introductionmentioning

confidence: 99%

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LINC00324 accelerates the proliferation and migration of osteosarcoma through regulating WDR66

et al. 2019

Journal Cellular Physiology

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Osteosarcoma (OS) is a type of malignancy featured with high morbidity and easy metastasis. Although past years have witnessed the great improvement in the treatments of OS, there remains a long way to go. Therefore, further research on the underlying molecular mechanism of OS progression is in imminent need. Long noncoding RNAs (lncRNA) are recognized as a cluster of transcripts over 200 bases.Increasing studies have unveiled their significant regulatory roles in cancers, including in osteosarcoma. Long intergenic non-protein coding RNA 324 (LINC00324) is a newly identified lncRNA exerting oncogenic functions in several cancers, but its role in OS is yet to be uncovered. Therefore, the present study planned to explore the role of LINC00324 in osteosarcoma. We first validated the upregulation of LINC00324 in OS tissues and cell lines and established its correlation with OS tumor progression and metastasis. Importantly, the prognostic significance of LINC00324 was identified in patients with OS. Gain-and loss-of-function assays revealed that LINC00324 accelerated cell proliferation and migration in OS. Mechanistically, we revealed that LINC00324 stabilized WD repeat-containing protein 66 (WDR66) messenger RNA through interacting with Hu antigen R. Rescue assays verified that WDR66 was required for the regulation of LINC00324 in promoting proliferation and migration of OS cells. In conclusion, the present study proved that LINC00324 accelerated the proliferation and migration of osteosarcoma cells through regulating WDR66, providing a new prognostic target for osteosarcoma. K E Y W O R D SLINC00324, migration, osteosarcoma, proliferation, WDR66

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