Corrected and Republished from: A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease

Uddén, Fabian; Ahl, Jonas; Littorin, Nils; Strålin, Kristoffer; Athlin, Simon; Riesbeck, Kristian

doi:10.1128/msphere.01102-20

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…In contrast to its opsonic counterpart, a non-opsonic antibody binds to its antigen without contributing to eradicating the pathogen by phagocytosis (Bahnan et al, 2021; Bläckberg et al, 2021; Forthal, 2015). Recently, Bläckberg et al reported that patients suffering from an invasive Streptococcus dysgalactiae infection failed to develop protective opsonic antibodies (Bläckberg et al, 2021), and Uddén et al found that the generation of non-opsonic antibody responses was correlated to the invasive nature of the Streptococcus pneumoniae infection (Uddén et al, 2020). However, it is unknown to what extent this occurs for S. pyogenes infections and how important the nature of the infection, and in particular invasive disease, is in developing opsonizing antibodies to S. pyogenes .…”

Section: Introductionmentioning

confidence: 99%

Invasive streptococcal infection can lead to the generation of cross-strain opsonic antibodies

Neergaard

Bläckberg

Ivarsson

et al. 2022

Preprint

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Introduction: The human pathogen Streptococcus pyogenes causes substantial morbidity and mortality. It is unclear if antibodies developed after infections with this pathogen are opsonic and if they are strain-specific or more broadly protective. Here, we quantified the opsonic antibody response following invasive S. pyogenes infection. Materials and Methods: Four patients with S. pyogenes bacteremia between 2018-2020 at Skåne University Hospital in Lund, Sweden, were prospectively enrolled. Acute and convalescent sera were obtained, and the S. pyogenes isolates were genome-sequenced (emm118, emm85, and two emm1). Quantitative antibody binding and phagocytosis assays were used to evaluate isolate-dependent opsonic antibody function in response to infection. Results: Antibody binding increased modestly against the infecting isolate and across emm types in convalescent compared to acute sera for all patients. For two patients, phagocytosis increased in convalescent serum for both the infecting isolate and across types. The increase was only across types for one patient, and one had no improvement. No correlation to the clinical outcomes was observed. Conclusions: Invasive S. pyogenes infections result in a modestly increased antibody binding with differential opsonic capacity, both non-functional binding and broadly opsonic binding across types. These findings question the dogma that an invasive infection should lead to a strong type-specific antibody increase rather than a more modest but broadly reactive response, as seen in these patients. Furthermore, our results indicate that an increase in antibody titers might not be indicative of an opsonic response and highlight the importance of evaluating antibody function in S. pyogenes infections.

show abstract

Section: Introductionmentioning

confidence: 99%

Invasive streptococcal infection can lead to the generation of cross-strain opsonic antibodies

Neergaard

Bläckberg

Ivarsson

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…In contrast to its opsonic counterpart, a nonopsonic antibody binds to its antigen without contributing to eradicating the pathogen by phagocytosis ( 16 , 21 , 22 ). Recently, Bläckberg et al reported that patients suffering from an invasive Streptococcus dysgalactiae infection failed to develop protective opsonic antibodies ( 22 ), and Uddén et al found that the generation of nonopsonic antibody responses was correlated with the invasive nature of the Streptococcus pneumoniae infection ( 23 ). However, it is unknown to what extent this occurs for S. pyogenes infections and how important the nature of the infection, and in particular invasive disease, is in developing opsonizing antibodies to S. pyogenes .…”

Section: Introductionmentioning

confidence: 99%

Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies

et al. 2022

View full text Add to dashboard Cite

show abstract

Corrected and Republished from: A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease

Cited by 2 publications

References 38 publications

Invasive streptococcal infection can lead to the generation of cross-strain opsonic antibodies

Invasive streptococcal infection can lead to the generation of cross-strain opsonic antibodies

Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies

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