Corrected Seminal Fructose Test

Gonzales, Gustavo F.

doi:10.3109/01485019408987798

Cited by 6 publications

(5 citation statements)

References 17 publications

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“…Corrected seminal fructose calculated as [log. sperm concentration]´[seminal fructose concentration] has been shown to be a better marker of the function of the seminal vesicles than measurement of seminal fructose concentration (Gonzales, 1989(Gonzales, , 1994aGonzales et al, 1989aGonzales et al, ,b, 1992aGonzales & Villena, 1997). Low levels of corrected seminal fructose have been observed in men with hypofunction of the seminal vesicles (Gonzales, 1989;Gonzales et al, 1989bGonzales et al, , 1992a and this has been related to male infertility.…”

Section: Introductionmentioning

confidence: 99%

True corrected seminal fructose level: a better marker of the function of seminal vesicles in infertile men

Gonzales

Villena

2001

Int J of Andrology

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This study was designed to determine if the value obtained after multiplying motile sperm concentration by seminal fructose concentration, named "true corrected fructose", correlates with sperm motility in asthenozoospermic men. Forty-two male partners in infertile couples were studied. Men were treated with 100 mg daily of clomiphene citrate for 5 days. Blood and semen samples were collected before treatment and 24 h after the end of treatment. Serum testosterone, seminal fructose and sperm motility were measured in each subject. Corrected fructose (log. sperm concentration multiplied by seminal fructose), and true corrected fructose (log. motile sperm concentration multiplied by seminal fructose) values were calculated. Prevalence of asthenozoospermia was 42.85% (18 of 42). Prevalence of hypofunction of the seminal vesicles was 9.5% using seminal fructose as a marker; 40.5% using seminal corrected fructose as a marker and 47.6% using true corrected fructose as a marker of seminal vesicle function. Regression analysis showed a better coefficient of determination between true corrected fructose and motile sperm concentration (R2=0.20, p < 0.001) than with corrected fructose (R(2)=0.05, p < 0.1) or fructose concentration (R(2)=0.006, p < 0.5). Asthenozoospermia was observed in 22.7% of subjects with normal function of the seminal vesicles, and in 65% of men with low values of true corrected fructose (z=6.02, p < 0.0001). Multivariate analysis showed that sperm motility grade 3 improved after treatment with clomiphene if true corrected fructose increased (p < 0.002). In those men whose seminal vesicle function improved after clomiphene treatment, a reduction in the prevalence of asthenozoospermia from 50 to 28.6% (z=3.10, p < 0.002) was observed whereas in those whose seminal vesicles did not respond to clomiphene the prevalence of asthenozoospermia was not reduced (z=1.05; p: NS). In conclusion, true corrected fructose measurement relates with sperm motility in cases of asthenozoospermia. Asthenozoospermia improves with clomiphene treatment if seminal vesicle function improves after treatment.

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Section: Introductionmentioning

confidence: 99%

True corrected seminal fructose level: a better marker of the function of seminal vesicles in infertile men

Gonzales

Villena

2001

Int J of Andrology

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“…For these reasons, insufficiency of seminal vesicles or excessive production of zinc by a prostatic inflammatory process may be associated with infertility due to failure in chromatin stability. The reference value found for FCV is ≥2.5 mg/million sperm/ml [11,14].…”

Section: Fructosementioning

confidence: 92%

“…The value of fructose expressed in "lower reference limit" discards if an extremely high value of fructose can be associated to an alteration in the metabolic pathway of sugars. Abnormally high values of fructose had been cited in individuals with diabetes, oligozoospermia and azoospermia [9][10][11]. The use of testosterone including in men with male accessory glands infection (MAGI) increases the seminal fructose [12].…”

Section: Fructosementioning

confidence: 99%

Male Accessory Glands and Sperm Function

Ricardo¹

2018

Spermatozoa - Facts and Perspectives

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With the advent of the techniques of reproduction, the functions of this fluid on the sperm function became a topic of lesser interest to the embryologist, urologist and andrologist. The interaction of spermatozoa with seminal plasma often goes unnoticed, but it is very likely that many substances produced by male accessory glands have impact on the sperm physiology. Seminal fluid contains several components besides spermatozoa; many of them are produced by a specific tissue and can be useful markers of secretion of the glands. The information in the 5th Manual of World Health Organization is very limited with respect to the interpretation in several characteristics abnormally high in semen. Male accessory glands secrete several factors such as alpha-glucosidase, fructose, prostaglandins, bicarbonate and citric acid among others, which are crucial for sperm physiology. This chapter deals with the interpretation of markers of accessory glands and their relation to some pathologies such as varicocele, infections, obstructions of the seminiferous pathways and some hormonal alterations.

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“…36 Fructose value (≥2.5 mg/million sperm/mL) is related to zinc chelation, fertilization, and sperm chromatin condensation. 37 In men with HPV infection, there is a failure of sperm condensation due to insufficient zinc production, which may be associated with male infertility. 38 Additionally, zinc is an essential element for the process of spermatogenesis and sperm motility.…”

Section: Composition Of Semen and Seminal Fluid In Hpv Infectionmentioning

confidence: 99%

“…The study highlighted that the semen has an average pH of 7.72 and constitutes a citrate concentration of 5.28 mg/mL, calcium at 0.28 mg/mL, potassium at 1.09 mg/mL, magnesium at 0.11 mg/mL, sodium at 3.00 mg/mL, zinc at 0.16 mg/mL, glucose at 1.02 mg/mL, fructose at 2.72 mg/mL, albumin at 15.5 mg/mL, and a total protein concentration of 50.36 mg/mL 36 . Fructose value (≥2.5 mg/million sperm/mL) is related to zinc chelation, fertilization, and sperm chromatin condensation 37 . In men with HPV infection, there is a failure of sperm condensation due to insufficient zinc production, which may be associated with male infertility 38 .…”

Section: Composition Of Semen and Seminal Fluid In Hpv Infectionmentioning

confidence: 99%

The impact of human papilloma virus on human reproductive health and the effect on male infertility: An updated review

Das

Fletcher

et al. 2023

Journal of Medical Virology

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It is believed that human papilloma virus infection (HPV), which is caused by the DNA virus, is the most prominent factor contributing to sexually transmitted disease (STD) in the world, with males having a prevalence rate of 3.5%-45% while that women are 2%-44%. Infertility is a rising problem on a global basis, affecting anywhere from 10% to 30% of couples who have reached reproductive age. This study aims to investigate the existing research on HPV, its connection to male infertility, and how it could be a helpful tool for medical professionals managing HPV in the context of reproductive health care. Infection with HPV has been identified as a risk factor for several spontaneous abortions; however, there is a lack of evidence on how HPV influences individuals undergoing assisted reproductive technology (ART) in terms of live births. The significance of the immune response to HPVinfected male reproductive system cells and its effect on embryos, as well as the oxidative stress generated by high-risk HPV DNA damage and genomic instability, is discussed in this review. Further, the association between male individuals infected with HPV and asthenozoospermia should provide a compelling case for vaccinating young people against HPV.

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Corrected Seminal Fructose Test

Cited by 6 publications

References 17 publications

True corrected seminal fructose level: a better marker of the function of seminal vesicles in infertile men

True corrected seminal fructose level: a better marker of the function of seminal vesicles in infertile men

Male Accessory Glands and Sperm Function

The impact of human papilloma virus on human reproductive health and the effect on male infertility: An updated review

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