Correcting abnormal mitochondrial dynamics to facilitate tumor treatment

Yang, Bowen; Lin, Yumeng; Shen, Yingqiang

doi:10.1016/j.mitoco.2023.07.001

Cited by 4 publications

(2 citation statements)

References 181 publications

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“…Recent research has explored alterations in protein expression linked with mitochondrial function, including OXPHOS, and key elements like PGC-1α, MnSOD, CypD, HIF-1α [34][35][36][37]. Also studied are proteins governing mitochondrial dynamics, such as DRP1, MFN1, MFN2, OPA1, and FIS1 [38][39][40]. Dysregulation or mutations coding these proteins have emerged as key factors in the context of neurodegenerative disorders, underlining their importance in the pathogenesis of these conditions [38][39][40].…”

Section: Neurodegenerative Diseases-gene Mutationsmentioning

confidence: 99%

“…Also studied are proteins governing mitochondrial dynamics, such as DRP1, MFN1, MFN2, OPA1, and FIS1 [38][39][40]. Dysregulation or mutations coding these proteins have emerged as key factors in the context of neurodegenerative disorders, underlining their importance in the pathogenesis of these conditions [38][39][40].…”

Section: Neurodegenerative Diseases-gene Mutationsmentioning

confidence: 99%

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Mitochondrial Dynamics in Neurodegenerative Diseases: Unraveling the Role of Fusion and Fission Processes

Grel,

Woznica,

Ratajczak

et al. 2023

IJMS

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Neurodegenerative diseases (NDs) are a diverse group of disorders characterized by the progressive degeneration and death of neurons, leading to a range of neurological symptoms. Despite the heterogeneity of these conditions, a common denominator is the implication of mitochondrial dysfunction in their pathogenesis. Mitochondria play a crucial role in creating biomolecules, providing energy through adenosine triphosphate (ATP) generated by oxidative phosphorylation (OXPHOS), and producing reactive oxygen species (ROS). When they’re not functioning correctly, becoming fragmented and losing their membrane potential, they contribute to these diseases. In this review, we explore how mitochondria fuse and undergo fission, especially in the context of NDs. We discuss the genetic and protein mutations linked to these diseases and how they impact mitochondrial dynamics. We also look at the key regulatory proteins in fusion (MFN1, MFN2, and OPA1) and fission (DRP1 and FIS1), including their post-translational modifications. Furthermore, we highlight potential drugs that can influence mitochondrial dynamics. By unpacking these complex processes, we aim to direct research towards treatments that can improve life quality for people with these challenging conditions.

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