Correction: A clinical and computational study on anti-obesity effects of hydroxycitric acid

Tomar, Manu; Rao, Raghavendra Pralhada; Dorairaj, Palaniyamma; Koshta, Abhishek; Suresh, Sowbhagya; Rafiq, Mohamed; Kumawat, Rajesh Kumar; Paramesh, Rangesh; V, Babu U.; Venkatesh, Kareenhalli V.

doi:10.1039/c9ra90051a

Cited by 3 publications

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“…HCA has two diastereomers because there are two chiral centres in the molecule. HCA is known to reduce weight gain and fat synthesis, 18 due to its anti-obesity effects and various mechanisms of action in the treatment of obesity. Primarily, HCA is a competitive inhibitor of the enzyme ATP-citrate lyase, which converts mitochondria-derived citrate to acetyl-CoA, a precursor for the fatty acid and mevalonate synthesis pathways.…”

Section: Introductionmentioning

confidence: 99%

Phytoformulation with hydroxycitric acid and capsaicin protects against high-fat-diet-induced obesity cardiomyopathy by reducing cardiac lipid deposition and ameliorating inflammation and apoptosis in the heart

Uddandrao,

Chandrasekaran,

Saravanan

et al. 2024

Journal of Traditional and Complementary Medicine

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Section: Introductionmentioning

confidence: 99%

Phytoformulation with hydroxycitric acid and capsaicin protects against high-fat-diet-induced obesity cardiomyopathy by reducing cardiac lipid deposition and ameliorating inflammation and apoptosis in the heart

Uddandrao,

Chandrasekaran,

Saravanan

et al. 2024

Journal of Traditional and Complementary Medicine

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Reprogramming of fatty acid metabolism in cancer

2019

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A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival. In particular, the importance of altered fatty acid metabolism in cancer has received renewed interest as, aside their principal role as structural components of the membrane matrix, they are important secondary messengers, and can also serve as fuel sources for energy production. In this review, we will examine the mechanisms through which cancer cells rewire their fatty acid metabolism with a focus on four main areas of research. (1) The role of de novo synthesis and exogenous uptake in the cellular pool of fatty acids. (2) The mechanisms through which molecular heterogeneity and oncogenic signal transduction pathways, such as PI3K-AKT-mTOR signalling, regulate fatty acid metabolism. (3) The role of fatty acids as essential mediators of cancer progression and metastasis, through remodelling of the tumour microenvironment. (4) Therapeutic strategies and considerations for successfully targeting fatty acid metabolism in cancer. Further research focusing on the complex interplay between oncogenic signalling and dysregulated fatty acid metabolism holds great promise to uncover novel metabolic vulnerabilities and improve the efficacy of targeted therapies.

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Targeting Nanotechnology and Nutraceuticals in Obesity: An Updated Approach

Behl

Singh

Sharma

et al. 2022

CPD

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Hypothesis: This review article represents a brief layout of the risk factors and pathophysiology responsible for obesity, customary treatment strategies, and nanotechnology-based nutraceutical for therapeutics of obesity. Experiments: An exhaustive search of the literature was done for this purpose, using Google Scholar, PubMed, and ScienceDirect databases. A study of the literature was conducted using publications published in peer-reviewed journals between the years 2000 and 2022. Findings: This was revealed that risk factors responsible for obesity were genetic abnormalities, environmental, and socio-economic factors. Number of research articles published between 2000 and 2022 were based on phytoconstituents based nanoformulation for obesity therapeutics and therefore, have been systematically compiled in this review. Various nutraceuticals like Garcinia cambogia, quercetin, resveratrol, capsaicin, Capsicum, Curcuma longa, Camella Sinensis, Zingiber officinalis, Citrus aurantium, Aegle marmelos, Coffea canephora, Asparagus officinalis, Gardenia jasminoides, Catha edulis, Clusia nemroisa, Rosmarinus officinalis, Cirsium setidens, Betula platyphylla, Tripterygium wilfordi possessing anti-obesity actions are discussed in this review along with their patents, clinical trials as well as their nanoformulation available. Conclusion: This review illustrates that the nanotechnology have a great propensity to impart promising role in the delivery of phytochemicals and nutraceuticals in management of obesity conditions and other related disorders.

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Correction: A clinical and computational study on anti-obesity effects of hydroxycitric acid

Abstract: Correction for ‘A clinical and computational study on anti-obesity effects of hydroxycitric acid’ by Manu Tomar et al., RSC Adv., 2019, 9, 18578–18588.

Cited by 3 publications

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Phytoformulation with hydroxycitric acid and capsaicin protects against high-fat-diet-induced obesity cardiomyopathy by reducing cardiac lipid deposition and ameliorating inflammation and apoptosis in the heart

Phytoformulation with hydroxycitric acid and capsaicin protects against high-fat-diet-induced obesity cardiomyopathy by reducing cardiac lipid deposition and ameliorating inflammation and apoptosis in the heart

Reprogramming of fatty acid metabolism in cancer

Targeting Nanotechnology and Nutraceuticals in Obesity: An Updated Approach

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