Correction: Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds

Axenov-Gribanov, Denis V.; Voytsekhovskaya, Irina V.; Tokovenko, Bogdan; Protasov, E S; Gamaiunov, Stanislav V.; Rebets, Yuriy; Luzhetskyy, Andriy; Timofeyev, Maxim A.

doi:10.1371/journal.pone.0152957

Cited by 16 publications

(12 citation statements)

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“…Regardless of efforts to produce new synthetic antibiotics [6], bioprospecting of natural environments has been responsible for the identification, production, and commercialization of most antibiotics [7] and it continues to provide key scaffolds for drug development [8]. Consequently, natural products—predominantly bacteria and fungi—are still the main sources for discovering novel antibiotics [7].…”

Section: Introductionmentioning

confidence: 99%

“…The antagonistic properties of organisms inhabiting extreme environments have not been investigated as extensively as they have for mesophiles [17]; however, the traditional approach of isolating and cultivating new microorganisms from underexplored habitats is still productive [6]. In recent years, research has exploited untapped and extreme environments, including the polar regions, complex marine habitats, and hyperthermal environments, to discover novel bioactive compounds with antibacterial, antifungal, and antitumor properties, and apply them to current clinical challenges [15,18,19,20,21].…”

Section: Introductionmentioning

confidence: 99%

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Advances in Antarctic Research for Antimicrobial Discovery: A Comprehensive Narrative Review of Bacteria from Antarctic Environments as Potential Sources of Novel Antibiotic Compounds Against Human Pathogens and Microorganisms of Industrial Importance

Núñez-Montero

Barrientos

2018

Antibiotics

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The recent emergence of antibiotic-resistant bacteria has become a critical public health problem. It is also a concern for industries, since multidrug-resistant microorganisms affect the production of many agricultural and food products of economic importance. Therefore, discovering new antibiotics is crucial for controlling pathogens in both clinical and industrial spheres. Most antibiotics have resulted from bioprospecting in natural environments. Today, however, the chances of making novel discoveries of bioactive molecules from various well-known sources have dramatically diminished. Consequently, unexplored and unique environments have become more likely avenues for discovering novel antimicrobial metabolites from bacteria. Due to their extreme polar environment, Antarctic bacteria in particular have been reported as a potential source for new antimicrobial compounds. We conducted a narrative review of the literature about findings relating to the production of antimicrobial compounds by Antarctic bacteria, showing how bacterial adaptation to extreme Antarctic conditions confers the ability to produce these compounds. We highlighted the diversity of antibiotic-producing Antarctic microorganisms, including the phyla Proteobacteria, Actinobacteria, Cyanobacteria, Firmicutes, and Bacteroidetes, which has led to the identification of new antibiotic molecules and supports the belief that research on Antarctic bacterial strains has important potential for biotechnology applications, while providing a better understanding of polar ecosystems.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Advances in Antarctic Research for Antimicrobial Discovery: A Comprehensive Narrative Review of Bacteria from Antarctic Environments as Potential Sources of Novel Antibiotic Compounds Against Human Pathogens and Microorganisms of Industrial Importance

Núñez-Montero

Barrientos

2018

Antibiotics

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“…All classes of antibiotics have seen emergence of resistance compromising their use; hence there is an urgent need for new bioactive compounds (Genilloud, 2014 ). The traditional approach consisting of isolation and cultivation of new microorganisms of underexplored habitats is still rewarding (Axenov-Gribanov et al, 2016 ), and has brought to the identification, production and commercialization of most of the antibiotics (Newman and Cragg, 2012 ). Despite the chemically synthetic efforts, natural environments are still the main source for the discovery of novel antibiotics (Fenical and Jensen, 2006 ; Bull and Stach, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring the Diversity and Antimicrobial Potential of Marine Actinobacteria from the Comau Fjord in Northern Patagonia, Chile

Undabarrena

Beltrametti²,

Claverías

et al. 2016

Front. Microbiol.

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Bioprospecting natural products in marine bacteria from fjord environments are attractive due to their unique geographical features. Although, Actinobacteria are well known for producing a myriad of bioactive compounds, investigations regarding fjord-derived marine Actinobacteria are scarce. In this study, the diversity and biotechnological potential of Actinobacteria isolated from marine sediments within the Comau fjord, in Northern Chilean Patagonia, were assessed by culture-based approaches. The 16S rRNA gene sequences revealed that members phylogenetically related to the Micrococcaceae, Dermabacteraceae, Brevibacteriaceae, Corynebacteriaceae, Microbacteriaceae, Dietziaceae, Nocardiaceae, and Streptomycetaceae families were present at the Comau fjord. A high diversity of cultivable Actinobacteria (10 genera) was retrieved by using only five different isolation media. Four isolates belonging to Arthrobacter, Brevibacterium, Corynebacterium and Kocuria genera showed 16S rRNA gene identity <98.7% suggesting that they are novel species. Physiological features such as salt tolerance, artificial sea water requirement, growth temperature, pigmentation and antimicrobial activity were evaluated. Arthrobacter, Brachybacterium, Curtobacterium, Rhodococcus, and Streptomyces isolates showed strong inhibition against both Gram-negative Pseudomonas aeruginosa, Escherichia coli and Salmonella enterica and Gram-positive Staphylococcus aureus, Listeria monocytogenes. Antimicrobial activities in Brachybacterium, Curtobacterium, and Rhodococcus have been scarcely reported, suggesting that non-mycelial strains are a suitable source of bioactive compounds. In addition, all strains bear at least one of the biosynthetic genes coding for NRPS (91%), PKS I (18%), and PKS II (73%). Our results indicate that the Comau fjord is a promising source of novel Actinobacteria with biotechnological potential for producing biologically active compounds.

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“…It has been previously shown that actinobacteria isolated from unusual ecosystems often produce new biologically active compounds ( 2 ). Recently, we reported the isolation of new actinobacterial strains from areas of endemicity such as Lake Baikal ( 3 ) and caves ( 4 ).…”

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of Streptomyces sp. Strain IB2014011-1, Isolated from Trichoptera sp. Larvae of Lake Baikal

et al. 2017

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Unique ecosystems with specific environmental conditions have been proven to be a promising source for isolation of new actinobacterial strains. Ancient Lake Baikal is one of the greatest examples of an ecosystem with high species biodiversity and endemicity caused by long-lasting isolated evolution and stable environmental conditions. Herein we report the draft genome sequence of Streptomyces sp. strain IB2014011-1, which was isolated from insect Trichoptera sp. larvae collected at the bottom of Lake Baikal.

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Correction: Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds

Cited by 16 publications

References 1 publication

Advances in Antarctic Research for Antimicrobial Discovery: A Comprehensive Narrative Review of Bacteria from Antarctic Environments as Potential Sources of Novel Antibiotic Compounds Against Human Pathogens and Microorganisms of Industrial Importance

Advances in Antarctic Research for Antimicrobial Discovery: A Comprehensive Narrative Review of Bacteria from Antarctic Environments as Potential Sources of Novel Antibiotic Compounds Against Human Pathogens and Microorganisms of Industrial Importance

Exploring the Diversity and Antimicrobial Potential of Marine Actinobacteria from the Comau Fjord in Northern Patagonia, Chile

Draft Genome Sequence of Streptomyces sp. Strain IB2014011-1, Isolated from Trichoptera sp. Larvae of Lake Baikal

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