Correction: ApoE2 Exaggerates PTSD-Related Behavioral, Cognitive, and Neuroendocrine Alterations

Johnson, Lance A.; Zuloaga, Damian G.; Bidiman, Erin; Marzulla, Tessa; Weber, Sydney; Wahbeh, Helané; Raber, Jacob

doi:10.1038/s41386-018-0261-z

Cited by 2 publications

(1 citation statement)

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“…With respect to neuropsychiatric associations a single small study found that e2 promoted risk for post-traumatic stress disorder (PTSD) ( Johnson et al, 2019 ). Further studies were negative as was a meta-analysis ( Roby, 2017 ), suggesting this was an exemplar of the “winner’s curse.” No studies have been published in the area of e2 associations with personality traits.…”

Section: Apoe E2 Pleiotropy For Riskmentioning

confidence: 99%

Apolipoprotein E Genotype e2: Neuroprotection and Its Limits

Kim

Devanand

Carlson

et al. 2022

Front. Aging Neurosci.

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In this review, we comprehensively, qualitatively, and critically synthesized several features of APOE-e2, a known APOE protective variant, including its associations with longevity, cognition, and neuroimaging, and neuropathology, all in humans. If e2’s protective effects—and their limits—could be elucidated, it could offer therapeutic windows for Alzheimer’s disease (AD) prevention or amelioration. Literature examining e2 within the years 1994–2021 were considered for this review. Studies on human subjects were selectively reviewed and were excluded if observation of e2 was not specified. Effects of e2 were compared with e3 and e4, separately and as a combined non-e2 group. Our examination of existing literature indicated that the most robust protective role of e2 is in longevity and AD neuropathologies, but e2’s effect on cognition and other AD imaging markers (brain structure, function, and metabolism) were inconsistent, thus inconclusive. Notably, e2 was associated with greater risk of non-AD proteinopathies and a disadvantageous cerebrovascular profile. We identified multiple methodological shortcomings of the literature on brain function and cognition that could have contributed to inconsistent and potentially misleading findings. We make careful interpretations of existing findings and provide directions for research strategies that could effectively examine the independent and unbiased effect of e2 on AD risk.

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Section: Apoe E2 Pleiotropy For Riskmentioning

confidence: 99%