Correction: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study

Miyashita, Hisanori; Hatsusaka, Natsuko; Shibuya, Eri; Mita, Norihiro; Yamazaki, Mai; Shibata, Teppei; Ishida, Hideyuki; Ukai, Yuki; Kubo, Eri; Sekiya, Hiroshi

doi:10.1371/journal.pone.0218857

Cited by 3 publications

(6 citation statements)

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“…Durant et al reported that the total number of analgesics used in the past year and total lifetime sunlight exposure were significantly associated with WC [20]. Conversely, Miyashita et al reported that lifetime ultraviolet exposure to the eye is negatively correlated with WC [14]. In this study, we examined the protein level and mRNA expression of AQP0, Cx46, and Cx50 in cataract lens to clarify the correlation between cataracts and cell adhesion molecules.…”

Section: Discussionmentioning

confidence: 86%

“…In this study, we classified the RD and WC grades by KMUCCGS depending on the number or the size of dots in the lens. In the Han Chinese general population, among three climatically different places (Sanya, Hainan, and Taiyuan, Shanxi, of China and Taichung, Taiwan), and in patients older than 40 years, the prevalence of RD was 16.2–40.7%, while it was 4.7–11.9% for WC [ 14 ]. According to the aforementioned studies, the two subtypes of cataracts are prevalent in the general population.…”

Section: Discussionmentioning

confidence: 99%

“…Thirteen eyes of 13 cataract patients (72.8 ± 8.6 years, 6 males and 7 females) who underwent cataract surgery in Kanazawa Medical University Hospital from June 2015 to August 2015 were enrolled in this study. Cataracts were diagnosed by one ophthalmologist from slit-lamp images of the right eyes obtained under maximal mydriasis and classified into the three major types (COR, NUC, and PSC) using the WHO classification system [15] and into the two subtypes (RD and WC) using KMUCCGS [14] ( Table 1). RD grade 1 was defined as fewer than 4 small dots observed within a central 3 mm zone of the pupil.…”

Section: Ocular Examinationmentioning

confidence: 99%

“…RD and WC are well correlated with the three major types of cataracts. Miyashita et al designed a classification of RD and WC according to the situation and the number or the size of dots (Kanazawa Medical University Cataract Classification and Grading System; KMUCCGS: Figure 1 ) [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Patient characteristics. COR, NUC, and PSC were graded using the WHO simplified cataract grading system, and RD and WC were graded using KMUCCGS[14] …”

mentioning

confidence: 99%

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Degradation of connexin 50 protein causes waterclefts in human lens

et al. 2020

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Cataracts are mainly classified into three types: cortical cataracts, nuclear cataracts, and posterior subcapsular cataracts. In addition, retrodots and waterclefts are cataract subtypes that cause decreased visual function. To maintain an orderly and tightly packed arrangement to minimize light scattering, adhesion molecules such as connexins and aquaporin 0 (AQP0) are highly expressed in the lens. We hypothesized that some main and/or subcataract type(s) are correlated with adhesion molecule degradation. Lens samples were collected from cataract patients during cataract surgery, and mRNA and protein expression levels were measured by real-time RT-PCR and western blotting, respectively. The mRNA levels of adhesion molecules were not significantly different among any cataract types. Moreover, AQP0 and connexin 46 protein expressions were unchanged among patients. However, connexin 50 protein level was significantly decreased in the lens of patients with WC cataract subtype. P62 and LC3B proteins were detected in the WC patients’ lenses, but not in other patients’ lenses. These results suggest that more research is needed on the subtypes of cataracts besides the three major types of cataract for tailor-made cataract therapy.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Ocular Examinationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Patient characteristics. COR, NUC, and PSC were graded using the WHO simplified cataract grading system, and RD and WC were graded using KMUCCGS[14] …”

mentioning

confidence: 99%

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Degradation of connexin 50 protein causes waterclefts in human lens

et al. 2020

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Effect of a Lens Protein in Low-Temperature Culture of Novel Immortalized Human Lens Epithelial Cells (iHLEC-NY2)

Yamamoto

Takeda

Hatsusaka

et al. 2020

Cells

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The prevalence of nuclear cataracts was observed to be significantly higher among residents of tropical and subtropical regions compared to those of temperate and subarctic regions. We hypothesized that elevated environmental temperatures may pose a risk of nuclear cataract development. The results of our in silico simulation revealed that in temperate and tropical regions, the human lens temperature ranges from 35.0 °C to 37.5 °C depending on the environmental temperature. The medium temperature changes during the replacement regularly in the cell culture experiment were carefully monitored using a sensor connected to a thermometer and showed a decrease of 1.9 °C, 3.0 °C, 1.7 °C, and 0.1 °C, after 5 min when setting the temperature of the heat plate device at 35.0 °C, 37.5 °C, 40.0 °C, and 42.5 °C, respectively. In the newly created immortalized human lens epithelial cell line clone NY2 (iHLEC-NY2), the amounts of RNA synthesis of αA crystallin, protein expression, and amyloid β (Aβ)1-40 secreted into the medium were increased at the culture temperature of 37.5 °C compared to 35.0 °C. In short-term culture experiments, the secretion of Aβ1-40 observed in cataracts was increased at 37.5 °C compared to 35.0 °C, suggesting that the long-term exposure to a high-temperature environment may increase the risk of cataracts.

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Background Factors Affecting the Radiation Exposure of the Lens of the Eye among Nurses in Interventional Radiology: A Quantitative Observational Study

Kuriyama,

Moritake,

Nakagami

et al. 2024

Nursing Reports

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With the International Commission on Radiological Protection’s (ICRP) reduction in the radiation dose threshold for cataracts, evaluating and preventing radiation exposure to the lens of the eye among interventional radiology (IR) staff have become urgent tasks. In this study, we focused on differences in lens-equivalent dose (HT Lens) to which IR nurses in three hospitals were exposed and aimed to identify factors underlying these differences. According to analyses of time-, distance-, and shielding-related factors, the magnitude of the HT Lens dose to which IR nurses were exposed could be explained not by time or shielding but by the distance between the X-ray exposure field and the location of the IR nurse. This distance tended to be shorter in hospitals with fewer staff. The most effective means of reducing the exposure of the lenses of IR nurses’ eyes to radiation is to position them at least two meters from the radiation source during angiography procedures. However, some hospitals must provide IR departments with comparatively few staff. In work environments where it is infeasible to reduce exposure by increasing distance, interventions to reduce time by managing working practices and investment in shielding equipment are also important. This study was not registered.

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Correction: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study

Cited by 3 publications

References 1 publication

Degradation of connexin 50 protein causes waterclefts in human lens

Degradation of connexin 50 protein causes waterclefts in human lens

Effect of a Lens Protein in Low-Temperature Culture of Novel Immortalized Human Lens Epithelial Cells (iHLEC-NY2)

Background Factors Affecting the Radiation Exposure of the Lens of the Eye among Nurses in Interventional Radiology: A Quantitative Observational Study

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