Correction: Biocompatible nitrogen-doped carbon dots: synthesis, characterization, and application

Park, Yoonsang; Kim, Yujin; Chang, Heemin; Won, Sungyeon; Kim, Hye Min; Kwon, Woosung

doi:10.1039/d0tb90176h

Cited by 13 publications

(1 citation statement)

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“…In modern nanotechnology, CQDs have been used to fabricate drug delivery, cellular bioimage, bio-sensing, and other biomedical applications [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Fighting Non-Small Lung Cancer Cells Using Optimal Functionalization of Targeted Carbon Quantum Dots Derived from Natural Sources Might Provide Potential Therapeutic and Cancer Bio Image Strategies

El-brolsy

Hanafy

El‐Kemary

2022

IJMS

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Non-small cell lung cancer (NSCLC) is an important sub-type of lung cancer associated with poor diagnosis and therapy. Innovative multi-functional systems are urgently needed to overcome the invasiveness of NSCLC. Carbon quantum dots (CQDs) derived from natural sources have received interest for their potential in medical bio-imaging due to their unique properties, which are characterized by their water solubility, biocompatibility, simple synthesis, and low cytotoxicity. In the current study, ethylene-diamine doped CQDs enhanced their cytotoxicity (98 ± 0.4%, 97 ± 0.38%, 95.8 ± 0.15%, 86 ± 0.15%, 12.5 ± 0.14%) compared to CQDs alone (99 ± 0.2%, 98 ± 1.7%, 96 ± 0.8%, 93 ± 0.38%, 91 ± 1.3%) at serial concentrations (0.1, 1, 10, 100, 1000 μg/mL). In order to increase their location in a specific tumor site, folic acid was used to raise their functional folate recognition. The apoptotic feature of A549 lung cells exposed to N-CQDs and FA-NCQDs was characterized by a light orange-red color under fluorescence microscopy. Additionally, much nuclear fragmentation and condensation were seen. Flow cytometry results showed that the percentage of cells in late apoptosis and necrosis increased significantly in treated cells to (19.7 ± 0.03%), (27.6 ± 0.06%) compared to untreated cells (4.6 ± 0.02%), (3.5 ± 0.02%), respectively. Additionally, cell cycle arrest showed a strong reduction in cell numbers in the S phase (14 ± 0.9%) compared to untreated cells (29 ± 0.5%). Caspase-3 levels were increased significantly in A549 exposed to N-CQDs (2.67 ± 0.2 ng/mL) and FA-NCQDs (3.43 ± 0.05 ng/mL) compared to untreated cells (0.34 ± 0.04 ng/mL). The functionalization of CQDs derived from natural sources has proven their potential application to fight off non-small lung cancer

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“…In modern nanotechnology, CQDs have been used to fabricate drug delivery, cellular bioimage, bio-sensing, and other biomedical applications [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Fighting Non-Small Lung Cancer Cells Using Optimal Functionalization of Targeted Carbon Quantum Dots Derived from Natural Sources Might Provide Potential Therapeutic and Cancer Bio Image Strategies

El-brolsy

Hanafy

El‐Kemary

2022

IJMS

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Green and Near-Infrared Dual-Mode Afterglow of Carbon Dots and Their Applications for Confidential Information Readout

Wang

Jiang

et al. 2021

Nano-Micro Lett.

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Near-infrared (NIR), particularly NIR-containing dual-/multi-mode afterglow, is very attractive in many fields of application, but it is still a great challenge to achieve such property of materials. Herein, we report a facile method to prepare green and NIR dual-mode afterglow of carbon dots (CDs) through in situ embedding o-CDs (being prepared from o-phenylenediamine) into cyanuric acid (CA) matrix (named o-CDs@CA). Further studies reveal that the green and NIR afterglows of o-CDs@CA originate from thermal activated delayed fluorescence (TADF) and room temperature phosphorescence (RTP) of o-CDs, respectively. In addition, the formation of covalent bonds between o-CDs and CA, and the presence of multiple fixation and rigid effects to the triplet states of o-CDs are confirmed to be critical for activating the observed dual-mode afterglow. Due to the shorter lifetime and insensitiveness to human vision of the NIR RTP of o-CDs@CA, it is completely covered by the green TADF during directly observing. The NIR RTP signal, however, can be readily captured if an optical filter (cut-off wavelength of 600 nm) being used. By utilizing these unique features, the applications of o-CDs@CA in anti-counterfeiting and information encryption have been demonstrated with great confidentiality. Finally, the as-developed method was confirmed to be applicable to many other kinds of CDs for achieving or enhancing their afterglow performances.

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Carbon dots and gold nanoparticles doped metal-organic frameworks as high-efficiency ECL emitters for monitoring of cell apoptosis

Liang

Zhao

et al. 2021

Microchemical Journal

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Correction: Biocompatible nitrogen-doped carbon dots: synthesis, characterization, and application

Abstract: Correction for ‘Biocompatible nitrogen-doped carbon dots: synthesis, characterization, and application’ by Yoonsang Park et al., J. Mater. Chem. B, 2020, DOI: 10.1039/d0tb01334j.

Cited by 13 publications

References 0 publications

Fighting Non-Small Lung Cancer Cells Using Optimal Functionalization of Targeted Carbon Quantum Dots Derived from Natural Sources Might Provide Potential Therapeutic and Cancer Bio Image Strategies

Fighting Non-Small Lung Cancer Cells Using Optimal Functionalization of Targeted Carbon Quantum Dots Derived from Natural Sources Might Provide Potential Therapeutic and Cancer Bio Image Strategies

Green and Near-Infrared Dual-Mode Afterglow of Carbon Dots and Their Applications for Confidential Information Readout

Carbon dots and gold nanoparticles doped metal-organic frameworks as high-efficiency ECL emitters for monitoring of cell apoptosis

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