Correction: Change in the Interstitial Cells of Cajal and nNOS Positive Neuronal Cells with Aging in the Stomach of F344 Rats

Kwon, Yong Hwan; Kim, Nayoung; Nam, Ryoung Hee; Park, Ji Hyun; Lee, Sun Min; Kim, Sung Kook; Lee, Hye Seung; Kim, Yong‐Sung; Lee, Dong Hoon

doi:10.1371/journal.pone.0179107

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“…An age‐associated reduction in ICC density has been reported in human colon and stomach,7 and rat proximal colon8 and stomach 9. The results obtained here for the mouse terminal bowel are therefore in line with previous reports on other parts of the GI tract in two other species, indicating that a reduction in ICC network volume during ageing may be a general phenomenon.…”

Section: Discussionsupporting

confidence: 92%

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Interstitial cell network volume is reduced in the terminal bowel of ageing mice

Gamage

Patel

Yeoman

et al. 2018

J Cellular Molecular Medi

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Ageing is associated with impaired neuromuscular function of the terminal gastrointestinal (GI) tract, which can result in chronic constipation, faecal impaction and incontinence. Interstitial cells of cajal (ICC) play an important role in regulation of intestinal smooth muscle contraction. However, changes in ICC volume with age in the terminal GI tract (the anal canal including the anal sphincter region and rectum) have not been studied. Here, the distribution, morphology and network volume of ICC in the terminal GI tract of 3‐ to 4‐month‐old and 26‐ to 28‐month‐old C57BL/6 mice were investigated. ICC were identified by immunofluorescence labelling of wholemount preparations with an antibody against c‐Kit. ICC network volume was measured by software‐based 3D volume rendering of confocal Z stacks. A significant reduction in ICC network volume per unit volume of muscle was measured in aged animals. No age‐associated change in ICC morphology was detected. The thickness of the circular muscle layer of the anal sphincter region and rectum increased with age, while that in the distal colon decreased. These results suggest that ageing is associated with a reduction in the network volume of ICC in the terminal GI tract, which may influence the normal function of these regions.

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Section: Discussionsupporting

confidence: 92%

“…In humans, a loss of ICC and a reduction in ICC network volume in normal stomach and colon with age have been described,7 while in ageing rats, a reduction in density of ICC has been reported in the proximal colon8 and stomach 9. A reduction in c‐Kit protein levels has also been described in the ageing rat colon 10.…”

Section: Introductionmentioning

confidence: 99%