Correction for Yu et al., “C-Terminal HIV-1 Transframe p6* Tetrapeptide Blocks Enhanced Gag Cleavage Incurred by Leucine Zipper Replacement of a Deleted p6* Domain”

Yu, Fu-Hsien; Huang, Kang-Chieh; Wang, Chin-Tien

doi:10.1128/jvi.00727-17

Cited by 9 publications

(10 citation statements)

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“…The 3-year DFS rates were 97.4% for patients with pathologic stage I disease, 84.5% for those with stage II disease, and 58.8% for those with stage III disease. These findings were similar to those of patients who underwent distal gastrectomy with standard D2 lymphadenectomy (including open and laparoscopic surgery) in a multicenter prospective study (CLASS-01) 11 (eFigure 3 in the Supplement).…”

Section: Survival Outcomes and Benefitssupporting

confidence: 78%

“…7,9 According to the Japanese gastric cancer treatment guidelines, distal gastrectomy with D2 LN dissection is the current standard for advanced gastric cancer located in the lower or middle third of the stomach. 5 Compared with the long-term survival of patients who underwent standard radical gastrectomy, we found that the survival of patients with different stages of disease who underwent LSTG was comparable to that of patients with laparoscopic distal gastrectomy and open distal gastrectomy in the CLASS-01 study, 11 which indicates that LSTG for AUTGC has feasible long-term outcomes.…”

Section: Discussionmentioning

confidence: 72%

“…19 Recurrence was identified by medical history and physical examination in combination with imaging evaluation, cytologic analysis, or tissue biopsy (preferred when feasible). 11 To evaluate the therapeutic value of dissection at each LN station, we used the therapeutic value index proposed by Sasako et al 20 The frequency of metastasis to each station was then calculated by dividing the number of patients with metastasis at that station by the number in whom the station was dissected. The 3-year therapeutic value index was calculated by multiplying the frequency of metastasis to the station by the 3-year survival rate of patients with metastasis to each station.…”

Section: End Points and Definitionsmentioning

confidence: 99%

“…The safety and feasibility of laparoscopic techniques in gastric cancer have been increasingly confirmed. 11,12 Although previous studies [13][14][15] have found that laparoscopic spleen-preserving splenic hilar lymphadenectomy is technically feasible, most are single-center studies, [13][14][15] and high-level clinical evidence is lacking.…”

Section: Introductionmentioning

confidence: 99%

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Outcomes of Laparoscopic Total Gastrectomy Combined With Spleen-Preserving Hilar Lymphadenectomy for Locally Advanced Proximal Gastric Cancer

Zheng

Zhao

et al. 2021

JAMA Netw Open

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IMPORTANCEThe long-term survival of patients with laparoscopic total gastrectomy combined with spleen-preserving splenic hilar lymphadenectomy (LSTG) for advanced upper-third gastric cancer (AUTGC) and the association of splenic hilar lymph node (LN-10) metastasis with survival remain controversial. OBJECTIVETo evaluate the long-term outcomes of LSTG and the value index of LN-10 metastasis for patients with AUTGC. DESIGN, SETTING, AND PARTICIPANTS The Chinese Laparoscopic Gastrointestinal Surgery Study 4 (CLASS-04) was a prospective, multicenter, single-arm trial that involved 19 centers in China. A total of 251 eligible patients with clinical stage T2, T3, or T4a upper-third gastric cancer without distant metastases were enrolled from September 1, 2016, to October 31, 2017. The final follow-up was on December 31, 2020. INTERVENTIONS All patients were enrolled to undergo LSTG. MAIN OUTCOMES AND MEASURESThe main outcomes were the 3-year overall survival (OS) and disease-free survival (DFS). Multivariate analyses were used to explore the association of LN-10 metastasis with survival. RESULTSAmong the 251 patients, 246 (98.0%; mean [SD] age, 60.1 [9.4] years; 197 [80.1%] male)underwent LSTG and completed the study. The 3-year OS was 79.1% (95% CI, 74.0%-84.2%), and the 3-year DFS was 73.1% (95% CI, 67.4%-78.8%). In addition, the 3-year therapeutic value index of LN-10 dissection was 4.5, exceeding the indexes for the partial D2 LN group (including LNs 5, 6, 11d, and 12a). Nineteen patients (7.7%) with LN-10 metastasis had significantly worse survival than the nonmetastasis group, and multivariate analysis revealed that splenic LN-10 metastasis was an independent risk factor (OS: hazard ratio [HR], 2.38; 95% CI, 1.08-5.26; P = .03; DFS: HR, 2.28; 95% CI, 1.12-4.63; P = .02). Moreover, patients with LN-10 metastasis were more likely to have recurrence (42.1% vs 20.7%, P = .03), especially when multiple site metastasis was present (21.1% vs 4.4%, P = .01). However, patients with LN-10 metastasis who received adjuvant chemotherapy had significantly better OS and DFS than those without adjuvant chemotherapy and achieved the same oncologic effect as those without LN-10 metastasis. (continued) Key Points Question What are the 3-year outcomes after laparoscopic total gastrectomy combined with spleenpreserving splenic hilar lymphadenectomy for patients with locally advanced proximal gastric cancer? Findings In this nonrandomized clinical trial of 251 patients with clinically staged, locally advanced upper-third gastric cancer, the 3-year overall survival was 79.1%. The 3-year therapeutic value index of lymph node 10 dissection was 4.5, exceeding the index for the partial D2 lymph node group. Meaning The findings of this study suggest the utility of laparoscopic total gastrectomy combined with spleenpreserving splenic hilar lymphadenectomy for clinically staged, locally advanced upper-third gastric cancer.

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Section: Survival Outcomes and Benefitssupporting

confidence: 78%

Section: Discussionmentioning

confidence: 72%

Section: End Points and Definitionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Outcomes of Laparoscopic Total Gastrectomy Combined With Spleen-Preserving Hilar Lymphadenectomy for Locally Advanced Proximal Gastric Cancer

Zheng

Zhao

et al. 2021

JAMA Netw Open

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“…Based on these findings, postoperative recovery and long-term survival of patients with GC have improved significantly. [3][4][5][6] Although RCTs provide high-level evidence and have made important contributions to the advancement of treatment, research waste is inevitably a major challenge to evidence-based medicine. This means that wasteful RCTs used resources while the risks to participants increased.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and Research Waste Among Randomized Clinical Trials in Gastric Cancer

Lü

Song

et al. 2021

JAMA Netw Open

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Noninvasive Prediction of Occult Peritoneal Metastasis in Gastric Cancer Using Deep Learning

et al. 2021

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IMPORTANCE Occult peritoneal metastasis frequently occurs in patients with advanced gastric cancer and is poorly diagnosed with currently available tools. Because the presence of peritoneal metastasis precludes the possibility of curative surgery, there is an unmet need for a noninvasive approach to reliably identify patients with occult peritoneal metastasis. OBJECTIVE To assess the use of a deep learning model for predicting occult peritoneal metastasis based on preoperative computed tomography images. DESIGN, SETTING, AND PARTICIPANTSIn this multicenter, retrospective cohort study, a deep convolutional neural network, the Peritoneal Metastasis Network (PMetNet), was trained to predict occult peritoneal metastasis based on preoperative computed tomography images. Data from a cohort of 1225 patients with gastric cancer who underwent surgery at Sun Yat-sen University Cancer Center (Guangzhou, China) were used for training purposes. To externally validate the model, data were collected from 2 independent cohorts comprising a total of 753 patients with gastric cancer who underwent surgery at Nanfang Hospital (Guangzhou, China) or the Third Affiliated Hospital of Southern Medical University (Guangzhou, China). The status of peritoneal metastasis for all patients was confirmed by pathological examination of pleural specimens obtained during surgery. Detailed clinicopathological data were collected for each patient. Data analysis was performed between

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Correction for Yu et al., “C-Terminal HIV-1 Transframe p6* Tetrapeptide Blocks Enhanced Gag Cleavage Incurred by Leucine Zipper Replacement of a Deleted p6* Domain”

Cited by 9 publications

References 0 publications

Outcomes of Laparoscopic Total Gastrectomy Combined With Spleen-Preserving Hilar Lymphadenectomy for Locally Advanced Proximal Gastric Cancer

Outcomes of Laparoscopic Total Gastrectomy Combined With Spleen-Preserving Hilar Lymphadenectomy for Locally Advanced Proximal Gastric Cancer

Characteristics and Research Waste Among Randomized Clinical Trials in Gastric Cancer

Noninvasive Prediction of Occult Peritoneal Metastasis in Gastric Cancer Using Deep Learning

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