Correction: Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in <i>GUCY2C</i>

Mishra, Vishwas; Bose, Avipsa; Kiran, Shashi; Banerjee, Sumilan; Shah, Ishfaq Ahmad; Chaukimath, Pooja; Reshi, Mudasir M.; Srinivas, Swarna; Barman, Anaxee; Visweswariah, Sandhya S.

doi:10.1084/jem.2021047909292021c

Journal of Experimental Medicine

2021

DOI: 10.1084/jem.2021047909292021c

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Correction: Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C

Vishwas Mishra¹,

Avipsa Bose²,

Shashi Kiran³

et al.

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Breaking Down Barriers: Epithelial Contributors to Monogenic IBD Pathogenesis

Ouahed,

Griffith,

Collen

et al. 2024

Inflammatory Bowel Diseases

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Monogenic causes of inflammatory bowel diseases (IBD) are increasingly being discovered. To date, much attention has been placed in those resulting from inborn errors of immunity. Therapeutic efforts have been largely focused on offering personalized immune modulation or curative bone marrow transplant for patients with IBD and underlying immune disorders. To date, less emphasis has been placed on monogenic causes of IBD that pertain to impairment of the intestinal epithelial barrier. Here, we provide a comprehensive review of monogenic causes of IBD that result in impaired intestinal epithelial barrier that are categorized into 6 important functions: (1) epithelial cell organization, (2) epithelial cell intrinsic functions, (3) epithelial cell apoptosis and necroptosis, (4) complement activation, (5) epithelial cell signaling, and (6) control of RNA degradation products. We illustrate how impairment of any of these categories can result in IBD. This work reviews the current understanding of the genes involved in maintaining the intestinal barrier, the inheritance patterns that result in dysfunction, features of IBD resulting from these disorders, and pertinent translational work in this field.

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Breaking Down Barriers: Epithelial Contributors to Monogenic IBD Pathogenesis

Ouahed,

Griffith,

Collen

et al. 2024

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

show abstract

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Correction: Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C

Cited by 1 publication

References 0 publications

Breaking Down Barriers: Epithelial Contributors to Monogenic IBD Pathogenesis

Breaking Down Barriers: Epithelial Contributors to Monogenic IBD Pathogenesis

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