Correction: LINC01152 upregulates MAML2 expression to modulate the progression of glioblastoma multiforme via Notch signaling pathway

Wu, Jianheng; Wang, Nannan; Yang, Ying; Jiang, Guangyuan; Mu, Qingchun; Zhan, Hui; Li, Fuyong

doi:10.1038/s41419-021-04106-8

Cited by 5 publications

(4 citation statements)

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“…Some significant differential expressed miRNAs, including miR-539, miR-500, and miR-466, have already been shown to play an important role in neuropathic pain. [47][48][49] It should be noted, however, that other miRNAs not selected as candidates here may also be associated with RIH if they influence the expression of highly pronociceptive-related genes. Other strengths of this study include the caudal intravenous injection route, which can provide more stable blood concentration and is more similar to clinical practice, considering individual differences in absorption ability and variations in blood concentration.…”

Section: Discussionmentioning

confidence: 99%

Spinal microRNA-134-5p targets glutamate receptor ionotropic kainate 3 to modulate opioid induced hyperalgesia in mice

et al. 2023

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Background: Fentanyl and its analogs are extensively used for pain relief. However, their paradoxically pronociceptive effects often lead to increased opioids consumption and risk of chronic pain. Compared to other synthetic opioids, remifentanil has been strongly linked to acute opioid hyperalgesia after exposure [remifentanil-induced hyperalgesia (RIH)]. The epigenetic regulation of microRNAs (miRNAs) on targeted mRNAs has emerged as an important pathogenesis in pain. The current research aimed at exploring the significance and contributions of miR-134-5p to the development of RIH. Methods: Both the antinociceptive and pronociceptive effects of two commonly used opioids were assessed, and miRNA expression profiles in the spinal dorsal horn (SDH) of mice acutely exposed to remifentanil and remifentanil equianalgesic dose (RED) sufentanil were screened. Next, the candidate miRNA level, cellular distribution, and function were examined by qPCR, fluorescent in situ hybridization (FISH) and Argonaute-2 immunoprecipitation. Furthermore, bioinformatics analysis, luciferase assays, miRNA overexpression, behavioral tests, golgi staining, electron microscopy, whole-cell patch-clamp recording, and immunoblotting were employed to investigate the potential targets and mechanisms underlying RIH. Results: Remifentanil induced significant pronociceptive effects and a distinct miRNA-profile from sufentanil when compared to saline controls. Among top 30 differentially expressed miRNAs spectrum, spinal miR-134-5p was dramatically downregulated in RIH mice but remained comparative in mice subjected to sufentanil. Moreover, Glutamate Receptor Ionotropic Kainate 3 (Grik3) was a target of miR-134-5p. The overexpression of miR-134-5p attenuated the hyperalgesic phenotype, excessive dendritic spine remodeling, excitatory synaptic structural plasticity, and Kainate receptor-mediated miniature excitatory postsynaptic currents (mEPSCs) in SDH resulting from remifentanil exposure. Besides, intrathecal injection of selective KA-R antagonist was able to reverse the GRIK3 membrane trafficking and relieved RIH. Conclusion: The miR-134-5p contributes to remifentanil-induced pronociceptive features via directly targeting Grik3 to modulate dendritic spine morphology and synaptic plasticity in spinal neurons.

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Section: Discussionmentioning

confidence: 99%

Spinal microRNA-134-5p targets glutamate receptor ionotropic kainate 3 to modulate opioid induced hyperalgesia in mice

et al. 2023

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“…Among these 24 shared differentially expressed lncRNAs, only one up-and three down-regulated lncRNAs were described in publications. One up-regulated lncRNA is LINC01152 (long intergenic non-protein coding RNA 1152), which has been reported to promote cell proliferation and survival in hepatocellular carcinoma [51] and functions as an miRNA sponge in glioblastoma multiforme cells to sequester miR-466 [52]. When the overlapping genes among the etiologies were searched, there were 45 upand 39 down-regulated genes shared among all three etiologies compared to the control, including 14 up-regulated and 10 down-regulated lncRNA genes (Figure 4C and Supplementary Table S2).…”

Section: Severeal Differentially Expressed Lncrna Genes Are Shared In...mentioning

confidence: 99%

“…Among these 24 shared differentially expressed lncRNAs, only one up-and three down-regulated lncRNAs were described in publications. One up-regulated lncRNA is LINC01152 (long intergenic non-protein coding RNA 1152), which has been reported to promote cell proliferation and survival in hepatocellular carcinoma [51] and functions as an miRNA sponge in glioblastoma multiforme cells to sequester miR-466 [52]. Three down-regulated lncRNA genes are EPB41L4A-DT (EPB41L4A divergent transcript), HOXC-AS2 (HOXC cluster antisense RNA 2), and LINC02323 (long intergenic non-protein coding RNA 2323).…”

Section: Severeal Differentially Expressed Lncrna Genes Are Shared In...mentioning

confidence: 99%

CrohnDB: A Web Database for Expression Profiling of Protein-Coding and Long Non-Coding RNA Genes in Crohn Disease

et al. 2023

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Crohn disease (CD) is a type of inflammatory bowel disease that causes inflammation in the digestive tract. Cases of CD are increasing worldwide, calling for more research to elucidate the pathogenesis of CD. For this purpose, the usage of the RNA-sequencing (RNA-seq) technique is increasingly appreciated, as it captures RNA expression patterns at a particular time point in a high-throughput manner. Although many RNA-seq datasets are generated from CD patients and compared to those of healthy donors, most of these datasets are analyzed only for protein-coding genes, leaving non-coding RNAs (ncRNAs) undiscovered. Long non-coding RNAs (lncRNAs) are any ncRNAs that are longer than 200 nucleotides. Interest in studying lncRNAs is increasing rapidly, as lncRNAs bind other macromolecules (DNA, RNA, and/or proteins) to finetune signaling pathways. To fill the gap in knowledge about lncRNAs in CD, we performed secondary analysis of published RNA-seq data of CD patients compared to healthy donors to identify lncRNA genes and their expression changes. To further facilitate lncRNA research in CD, we built a web database, CrohnDB, to provide a one-stop-shop for expression profiling of protein-coding and lncRNA genes in CD patients compared to healthy donors.

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“…LINC01152 and MAML2 3′UTR have binding sites for miR-466. miR-466 inhibition could in part reverse the enhanced apoptosis observed after LINC01152 silencing ( Wu et al, 2021 ). High levels of LncRNA SNHG3 are observed in glioma.…”

Section: Non-coding Rnas and Brain Tumorsmentioning

confidence: 99%

Non-Coding RNAs and Brain Tumors: Insights Into Their Roles in Apoptosis

Tamtaji

Derakhshan

Noshabad

et al. 2022

Front. Cell Dev. Biol.

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A major terrifying ailment afflicting the humans throughout the world is brain tumor, which causes a lot of mortality among pediatric and adult solid tumors. Several major barriers to the treatment and diagnosis of the brain tumors are the specific micro-environmental and cell-intrinsic features of neural tissues. Absence of the nutrients and hypoxia trigger the cells’ mortality in the core of the tumors of humans’ brains: however, type of the cells’ mortality, including apoptosis or necrosis, has been not found obviously. Current studies have emphasized the non-coding RNAs (ncRNAs) since their crucial impacts on carcinogenesis have been discovered. Several investigations suggest the essential contribution of such molecules in the development of brain tumors and the respective roles in apoptosis. Herein, we summarize the apoptosis-related non-coding RNAs in brain tumors.

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Correction: LINC01152 upregulates MAML2 expression to modulate the progression of glioblastoma multiforme via Notch signaling pathway

Cited by 5 publications

References 0 publications

Spinal microRNA-134-5p targets glutamate receptor ionotropic kainate 3 to modulate opioid induced hyperalgesia in mice

Spinal microRNA-134-5p targets glutamate receptor ionotropic kainate 3 to modulate opioid induced hyperalgesia in mice

CrohnDB: A Web Database for Expression Profiling of Protein-Coding and Long Non-Coding RNA Genes in Crohn Disease

Non-Coding RNAs and Brain Tumors: Insights Into Their Roles in Apoptosis

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