Correction: Long-Circulating Curcumin-Loaded Liposome Formulations with High Incorporation Efficiency, Stability and Anticancer Activity towards Pancreatic Adenocarcinoma Cell Lines In Vitro

Mahmud, Mohamed; Piwoni, Adriana; Filipczak, Nina; Janicka, Martyna; Gubernator, Jerzy

doi:10.1371/journal.pone.0173728

Cited by 9 publications

(2 citation statements)

References 1 publication

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“…Liposomal curcumin has been reported to exhibit higher stability than free curcumin in phosphate buffered saline (PBS), human blood, plasma and cell culture media [37]. Moreover, curcumin-loaded LPs have been shown to induce apoptosis and suppress tumor proliferation and angiogenesis of several cancer cell lines by downregulating the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and many anti-apoptosis proteins including B-cell lymphoma 2 (Bcl2), B-cell lymphoma-extra large (BclXL), and cyclooxygenase-2 (COX-2) [38,39].…”

Section: Introductionmentioning

confidence: 99%

Magnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potential

Halevas

Mavroidi

Swanson

et al. 2019

Journal of Inorganic Biochemistry

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In this work novel magnetic cationic liposomal nanoformulations were synthesized for the encapsulation of a crystallographically defined ternary V(IV)-curcumin-bipyridine (VCur) complex with proven bioactivity, as potential anticancer agents. The liposomal vesicles were produced via the thin film hydration method employing N- [1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium (DOTAP) and egg phosphatidylcholine lipids and were magnetized through the addition of citric acid surface-modified monodispersed magnetite colloidal magnetic nanoparticles. The obtained nanoformulations were evaluated for their structural and textural properties and shown to have exceptional stability and enhanced solubility in physiological media, demonstrated by the entrapment efficiency and loading capacity results and the in vitro release studies of their cargo. Furthermore, the generated liposomal formulations preserved the superparamagnetic behavior of the employed magnetic core maintaining the physicochemical and morphological requirements for targeted drug delivery applications. The novel nanomaterials were further biologically evaluated for their DNA interaction potential and were found to act as intercalators. The findings suggest that the positively charged magnetic liposomal nanoformulations can generate increased concentration of their cargo at the DNA site, offering a further dimension in the importance of cationic liposomes as nanocarriers of hydrophobic anticancer metal ion complexes for the development of new multifunctional pharmaceutical nanomaterials with enhanced bioavailability and targeted antitumor activity.

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Section: Introductionmentioning

confidence: 99%

Magnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potential

Halevas

Mavroidi

Swanson

et al. 2019

Journal of Inorganic Biochemistry

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“…The three most common strategies for overcoming the poor bioavailability of curcumin are: (1) concomitant consumption of curcumin with other natural compounds such as piperine [32], which inhibits the activity of ABC transporters and prevents the return of curcumin to the intestinal light [33], (2) chemical modification of the curcumin molecule to obtain analogues in the form of hydrazinocurcumin [34], diphenyl difluoroketone [35], or PAC (3,5-bis(4-hydroxy-3-methoxybenzylidene)-N-methyl-4-piperidone) [36], which are more soluble and bioavailable, or (3) encapsulation methods, for the design of drug delivery systems, such as nanoparticles or solid molecules of small dimensions (1 to 600 nm) [37], micelles formed by monolayers of phospholipids [38], liposomes with several layers of amphipathic lipids [39], or niosomes formed by surfactants or non-ionic surfactants that form vesicles without the presence of phospholipids and cholesterol [40].…”

Section: Introductionmentioning

confidence: 99%

Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model

et al. 2019

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Prostate cancer (PCa) is one of the most common cancers in older men and is associated with high mortality. Despite advances in screening for early detection of PCa, a large proportion of patients continue to be diagnosed with metastatic disease, with ~20% of men showing a high tumor grade and stage. Medicinal plant extracts have a great potential to prevent/treat PCa, as well as to reduce its incidence/prevalence and improve survival rates. One of the most promising extracts is curcumin, which is a major, nontoxic, bioactive compound of Curcuma longa. Curcumin has strong antitumor activity in vitro. However, its potential beneficial in vivo affects are limited by its low intestinal absorption and rapid metabolism. In this study, curcumin was impregnated into a biodegradable poly(lactic-co-glycolic) acid (PLGA) support and characterized by FTIR and DSC, and its release by UV spectrophotometry. PLGA-curcumin was tested in different subcutaneous PCa xenograft models (PC3, 22rv1, and DU145 PCa cell-lines), and its effects evaluated by tumor progression an immuno-histochemical analysis (Trichromic, Ki67 and TUNEL stainings), were compared with those of a commercial curcumin preparation. Our results indicate that curcumin-impregnated PLGA is significantly more active (~2-fold increase) with respect to oral curcumin, which supports its use for subcutaneous administration.

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Curcumin on the “flying carpets” to modulate different signal transduction cascades in cancers: Next‐generation approach to bridge translational gaps

Çelik¹,

Aydin²,

Solak

et al. 2018

J of Cellular Biochemistry

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Curcumin, a bioactive and pharmacologically efficient component isolated from Curcuma longa has attracted considerable attention because of its ability to modulate diverse cellular and physiological pathways. WNT, TGF/SMAD, NOTCH, and SHH are fundamentally different signaling cascades, but their choreographed activation is strongly associated with cancer development and progression. In this review we have attempted to set spotlight on regulation of different cell signaling pathways by curcumin in different cancers. We partition this multi-component review into in-depth biological understanding of various signal transduction cascades and how curcumin targets intracellular signal transducers of deregulated pathways to inhibit cancer development and progression. Rapidly broadening landscape of both established and candidate oncogenic driver mutations identified in different cancers is a major stumbling block in the standardization of drugs having significant clinical outcome. Intra and inter-tumor heterogeneity had leveraged the complexity of therapeutic challenges to another level. Multi-pronged approach and molecularly guided treatments will be helpful in improving the clinical outcome.

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Correction: Long-Circulating Curcumin-Loaded Liposome Formulations with High Incorporation Efficiency, Stability and Anticancer Activity towards Pancreatic Adenocarcinoma Cell Lines In Vitro

Cited by 9 publications

References 1 publication

Magnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potential

Magnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potential

Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model

Curcumin on the “flying carpets” to modulate different signal transduction cascades in cancers: Next‐generation approach to bridge translational gaps

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