Correction: Myosin Light Chain Kinase (MLCK) Gene Influences Exercise Induced Muscle Damage during a Competitive Marathon

Coso, Juan Del; Valero, Marjorie; Lara, Beatriz; Salinero, Juan José; Gallo-Salazar, César; Areces, Francisco

doi:10.1371/journal.pone.0168309

PLoS ONE

2016

DOI: 10.1371/journal.pone.0168309

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Correction: Myosin Light Chain Kinase (MLCK) Gene Influences Exercise Induced Muscle Damage during a Competitive Marathon

Juan Del Coso¹,

Marjorie Valero²,

Beatriz Lara³

et al.

Abstract: There is an error in the last sentence of the Abstract. The correct sentence is: CA heterozygotes for MLCK C37885A might present lower exercise-induced muscle damage after a marathon competition than CC counterparts.

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Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review

et al. 2021

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Muscle damage induced by exercise may have several consequences such as delayed-onset muscle soreness, a side-effect of the release of free radicals during oxidative stress. To mitigate the oxidative stress cascade, the oral intake of antioxidants has been assessed by several research groups. This review examines whether supplementation with vitamin C and/or vitamin E is able to prevent or attenuate delayed-onset muscle soreness after eccentric exercise. The PubMed, Web of Science, Medline, and Embase databases were searched to identify studies meeting the inclusion criteria: primary randomized control trials, healthy male and female participants aged 16–80 years, and an intervention consisting of the intake of vitamin C and/or vitamin E without other supplements plus a controlled eccentric exercise regimen. Further requirements were the measurement of muscle soreness or markers of delayed-onset muscle soreness. All original full-text articles in English or translated into English published from January 2000 to June 2020 were considered for this review. Fourteen studies were finally identified, including 280 participants, 230 men, and 50 women aged 16–30 years. All participants were healthy individuals with different starting levels of physical activity. Supplementation was acute in two studies and chronic in 12, and its consisted of vitamin C in eight studies, vitamin E in two studies, and both in four studies. Only in 3 of the 14 studies was muscle soreness found to be significantly reduced in response to vitamin C and/or vitamin E supplementation at all time points when compared to the placebo group. Despite some studies showing the beneficial effects of chronic supplementation with these vitamins on muscle soreness manifesting 24–72 hours after eccentric exercise, the evidence is so far insufficient to confirm that the intake of antioxidant vitamins is able to minimize delayed-onset muscle soreness in this context.

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Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review

et al. 2021

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The Genetic Basis of Non-Contact Soft Tissue Injuries-Are There Practical Applications of Genetic Knowledge?

Borzemska,

Cięszczyk,

Żekanowski

2024

Cells

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Physical activity increases the risk of non-contact injuries, mainly affecting muscles, tendons, and ligaments. Genetic factors are recognized as contributing to susceptibility to different types of soft tissue injuries, making this broad condition a complicated multifactorial entity. Understanding genetic predisposition seems to offer the potential for personalized injury prevention and improved recovery strategies. The candidate gene analysis approach used so far, has often yielded inconclusive results. This manuscript reviews the most commonly studied genetic variants in genes involved in the musculoskeletal system’s structure and recovery processes (ACTN3, ACE, CKM, MLCK, AMPD1, IGF2, IL6, TNFα, CCL2, COL1A1, COL5A1, MMP3, and TNC). Referring to the literature, it was highlighted that single-gene analyses provide limited insight. On the other hand, novel genetic testing methods identify numerous variants of uncertain physiological relevance. Distinguishing between functionally important variants, modifying variants, and the thousands of irrelevant variants requires advanced bioinformatics methods and basic multiomics research to identify the key biological pathways contributing to injury susceptibility. Tools like the Total Genotype Score (TGS) and Polygenic Risk Score (PRS) offer a more holistic view by assessing the combined effect of multiple variants. However, these methods, while useful in research, lack clinical applicability. In conclusion, it is too early to determine the clinical implications of genetic variability as a tool for improving well-established training and injury prevention methods, as the predictive power of genetic testing for injury predisposition is currently low.

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Methodological Approach of the Iron and Muscular Damage: Female Metabolism and Menstrual Cycle during Exercise Project (IronFEMME Study)

Peinado

Alfaro-Magallanes

Romero-Parra

et al. 2021

IJERPH

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Background: The increase in exercise levels in the last few years among professional and recreational female athletes has led to an increased scientific interest about sports health and performance in the female athlete population. The purpose of the IronFEMME Study described in this protocol article is to determine the influence of different hormonal profiles on iron metabolism in response to endurance exercise, and the main markers of muscle damage in response to resistance exercise; both in eumenorrheic, oral contraceptive (OC) users and postmenopausal well-trained women. Methods: This project is an observational controlled randomized counterbalanced study. One hundered and four (104) active and healthy women were selected to participate in the IronFEMME Study, 57 of which were eumenorrheic, 31 OC users and 16 postmenopausal. The project consisted of two sections carried out at the same time: iron metabolism (study I) and muscle damage (study II). For the study I, the exercise protocol consisted of an interval running test (eight bouts of 3 min at 85% of the maximal aerobic speed), whereas the study II protocol was an eccentric-based resistance exercise protocol (10 sets of 10 repetitions of plate-loaded barbell parallel back squats at 60% of their one repetition maximum (1RM) with 2 min of recovery between sets). In both studies, eumenorrheic participants were evaluated at three specific moments of the menstrual cycle: early-follicular phase, late-follicular phase and mid-luteal phase; OC users performed the trial at two moments: withdrawal phase and active pill phase. Lastly, postmenopausal women were only tested once, since their hormonal status does not fluctuate. The three-step method was used to verify the menstrual cycle phase: calendar counting, blood test confirmation, and urine-based ovulation kits. Blood samples were obtained to measure sex hormones, iron metabolism parameters, and muscle damage related markers. Discussion: IronFEMME Study has been designed to increase the knowledge regarding the influence of sex hormones on some aspects of the exercise-related female physiology. Iron metabolism and exercise-induced muscle damage will be studied considering the different reproductive status present throughout well-trained females’ lifespan.

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Correction: Myosin Light Chain Kinase (MLCK) Gene Influences Exercise Induced Muscle Damage during a Competitive Marathon

Abstract: There is an error in the last sentence of the Abstract. The correct sentence is: CA heterozygotes for MLCK C37885A might present lower exercise-induced muscle damage after a marathon competition than CC counterparts.

Cited by 3 publications

References 1 publication

Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review

Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review

The Genetic Basis of Non-Contact Soft Tissue Injuries-Are There Practical Applications of Genetic Knowledge?

Methodological Approach of the Iron and Muscular Damage: Female Metabolism and Menstrual Cycle during Exercise Project (IronFEMME Study)

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