Correction: Petasites japonicus Stimulates the Proliferation of Mouse Spermatogonial Stem Cells

Kang, Hye–Ryun; Lee, Yong-An; Kim, Yong Hee; Lee, Dong Gu; Kim, Bang‐Jin; Kim, Ki‐Jung; Kim, Byung-Gak; Oh, Myeong-Geun; Han, Chan Kyu; Lee, Sang‐Hyun; Ryu, Buom‐Yong

doi:10.1371/journal.pone.0144480

Cited by 4 publications

(3 citation statements)

References 1 publication

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“…The levels of LH, FSH, testosterone, cholesterol, glycogen, and sialic acid came back to normal, which supported the fertility enhancing activities. Petasites japonicus MeOH extract proliferated the generation and activity of spermatogonial stem cells when treated to SSC/C57BL/6 mice at doses of 0.1, 1, 10 µg/mL for 7 days [71]. Elevated levels of LHX1 and GFRα1 were observed, which were used as markers of differentiation of spermatogonia at the basement membrane of seminiferous tubules.…”

Section: In Vivo Studiesmentioning

confidence: 99%

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Noh

Kim

et al. 2020

Antioxidants

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Infertility, a couple’s inability to conceive after one year of unprotected regular intercourse, is an important issue in the world. The use of natural products in the treatment of infertility has been considered as a possible alternative to conventional therapies. The present study aimed to investigate the effects and the mechanisms of various natural products on infertility. We collected articles regarding infertility and natural products using the research databases PubMed and Google Scholar. Several natural products possess antioxidant properties and androgenic activities on productive factors and hormones. Antioxidants are the first defense barrier against free radicals produced by oxidative stress (OS). They remove reactive oxygen stress (ROS), reducing insulin resistance, total cholesterol, fat accumulation, and cancer growth. Moreover, various natural products increase endometrial receptivity and fertility ability showing androgenic activities on productive factors and hormones. For example, Angelica keiskei powder and Astragalus mongholicus extract showed anti-infertility efficacies in males and females, respectively. On the other hand, adverse effects and acute toxicity of natural products were also reported. Tripterygium glycoside decreased fertility ability both in males and females. Results indicate that management of infertility with natural products could be beneficial with further clinical trials to evaluate the safety and effect.

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Section: In Vivo Studiesmentioning

confidence: 99%

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Noh

Kim

et al. 2020

Antioxidants

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“…The equation is calculated on the assumption that the number of germ cells was increased than initial number in control. Actually, the number of germ cells enriched for SSCs was increased 1.98-fold (2 × 10 5 to 3.8 × 10 5 ) on the average 59 .…”

Section: Methodsmentioning

confidence: 99%

“…After purification, Thy-1-positive (Thy-1 + ) cells were placed on 12-well culture plates containing mitotically inactivated SIM mouse embryo-derived thioguanine- and ouabain-resistant (STO) feeder cells. The cells were cultured in mouse serum-free medium (mSFM) including 10 ng/mL glial cell line-derived neurotrophic factors (GDNF; R&D Systems, Minneapolis, MN, USA), 75 ng/mL GDNF family receptor α1 (GFRα1; R&D Systems), and 1 ng/mL basic fibroblast growth factor 2 (bFGF2; BD Biosciences) as previously reported 57 – 59 . The culture medium was replaced every 2–3 days, and the cultured cells were passaged in a 1:2 or 1:3 ratio every week.…”

Section: Methodsmentioning

confidence: 99%

A Phytochemical Approach to Promotion of Self-renewal in Murine Spermatogonial Stem Cell by Using Sedum Sarmentosum Extract

Jung

Kim

Cho

et al. 2017

Sci Rep

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Spermatogonial stem cells (SSCs) are the basis of spermatogenesis, which is dependent on the ability to self-renew and differentiation. Controlling self-renewal and differentiation of SSCs could apply to treatment of disease such as male infertility. Recently, in the field of stem cell research, it was demonstrated that effective increase in stem cell activity can be achieved by using growth factors derived from plant extracts. In this study, our aim is to investigate components from natural plant to improve the self-renewal of SSCs. To find the components, germ cells were cultured with comprehensive natural plant extracts, and then the more pure fraction, and finally single compound at different concentrations. As a result, we found 5H-purin-6-amine at 1 µg/mL, originated from Sedum sarmentosum, was a very effective compound induced SSCs proliferation. Our data showed that germ cells cultured with 5H-purin-6-amine could maintain their stable characteristics. Furthermore, transplantation results demonstrated that 5H-purin-6-amine at 1 µg/mL increased the activity of SSCs, indicating the compound could increase true SSC concentration within germ cells to 1.96-fold. These findings would be contributed to improve further reproductive research and treat male infertility by using natural plant extracts.

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Liquid chromatography–tandem mass spectrometry quantification of acetamiprid and thiacloprid residues in butterbur grown under regulated conditions

Lee

Kim

El‐Aty

et al. 2017

Journal of Chromatography B

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Correction: Petasites japonicus Stimulates the Proliferation of Mouse Spermatogonial Stem Cells

Cited by 4 publications

References 1 publication

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

A Phytochemical Approach to Promotion of Self-renewal in Murine Spermatogonial Stem Cell by Using Sedum Sarmentosum Extract

Liquid chromatography–tandem mass spectrometry quantification of acetamiprid and thiacloprid residues in butterbur grown under regulated conditions

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