Correction: Polygonum cuspidatum and Its Active Components Inhibit Replication of the Influenza Virus through Toll-Like Receptor 9-Induced Interferon Beta Expression

Lin, Chao-Jen; Lin, Cheng‐Li; Chen, Ter-Hsin; Hsu, Yu-Chin; Liu, Chin‐San; Hwang, Guang-Yuh; Wan, Lei

doi:10.1371/journal.pone.0125288

Cited by 18 publications

(6 citation statements)

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“…Resveratrol also possesses anti-viral effects, though direct evidence linking cell-clearing pathways with the anti-viral effects of resveratrol is missing so far. However, resveratrol, either in vitro or in vivo, counteracts replication of the influenza virus, SARS-CoV, or MERS-CoV, through inhibition of the p38MAPK and PI3K/AKT/mTOR pathways, which are involved in autophagy impairment, besides virus-induced apoptosis and inflammation [ 89 , 178 , 179 , 180 , 181 ]. The in vivo and in vitro anti-influenza viral effects of resveratrol are already achieved at low, non-toxic concentrations of 1 mg/kg/day for 7 days and 62.5 μM, respectively [ 179 , 181 ].…”

Section: Anti-viral and Anti-inflammatory Effects Of Phytochemicalmentioning

confidence: 99%

“…The in vivo and in vitro anti-influenza viral effects of resveratrol are already achieved at low, non-toxic concentrations of 1 mg/kg/day for 7 days and 62.5 μM, respectively [ 179 , 181 ]. The antiviral efficacy of resveratrol is reduced when the cells are treated with neutralizing anti-IFN-β antibodies, suggesting that it acts synergistically with IFN-β, to inhibit influenza virus replication, while promoting the activation of the host immune response [ 180 ].…”

Section: Anti-viral and Anti-inflammatory Effects Of Phytochemicalmentioning

confidence: 99%

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Cell Clearing Systems as Targets of Polyphenols in Viral Infections: Potential Implications for COVID-19 Pathogenesis

et al. 2020

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The novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has generated the ongoing coronavirus disease-2019 (COVID-19) pandemic, still with an uncertain outcome. Besides pneumonia and acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), other features became evident in the context of COVID-19. These includes endothelial and coagulation dysfunction with disseminated intravascular coagulation (DIC), and multiple organ dysfunction syndrome (MODS), along with the occurrence of neurological alterations. The multi-system nature of such viral infection is a witness to the exploitation and impairment of ubiquitous subcellular and metabolic pathways for the sake of its life-cycle, ranging from host cell invasion, replication, transmission, up to a cytopathic effect and overt systemic inflammation. In this frame, alterations in cell-clearing systems of the host are emerging as a hallmark in the pathogenesis of various respiratory viruses, including SARS-CoV-2. Indeed, exploitation of the autophagy and proteasome pathways might contribute not only to the replication of the virus at the site of infection but also to the spreading of either mature virions or inflammatory mediators at both cellular and multisystem levels. In this frame, besides a pharmacological therapy, many researchers are wondering if some non-pharmacological substances might counteract or positively modulate the course of the infection. The pharmacological properties of natural compounds have gained increasing attention in the field of alternative and adjunct therapeutic approaches to several diseases. In particular, several naturally-occurring herbal compounds (mostly polyphenols) are reported to produce widespread antiviral, anti-inflammatory, and anti-oxidant effects while acting as autophagy and (immuno)-proteasome modulators. This article attempts to bridge the perturbation of autophagy and proteasome pathways with the potentially beneficial effects of specific phytochemicals and flavonoids in viral infections, with a focus on the multisystem SARS-CoV-2 infection.

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Section: Anti-viral and Anti-inflammatory Effects Of Phytochemicalmentioning

confidence: 99%

Section: Anti-viral and Anti-inflammatory Effects Of Phytochemicalmentioning

confidence: 99%

Cell Clearing Systems as Targets of Polyphenols in Viral Infections: Potential Implications for COVID-19 Pathogenesis

et al. 2020

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“…They have a distinctive structural skeleton consisting of one or more aromatic phenyl rings connected to hydroxyl groups and exhibiting a wide spectrum of health-related properties including antioxidant protection, anti-inflammatory, anti-allergic, anti-atherogenic, and anti-cancer (Gorzynik-Debicka et al, 2018 ; Serreli and Deiana, 2019 ). Moreover, several studies demonstrated the antiviral potential of some classes of polyphenols against Epstein–Barr virus (Yiu et al, 2010 ), enterovirus 71 (Zhang et al, 2015 ), herpes simplex virus (HSV) (Annunziata et al, 2018 ), influenza virus (Lin et al, 2015 ), and other viruses causing respiratory tract-related infections (Zang et al, 2011 ). The mechanisms underpinning the antiviral activity of polyphenols are varied (for a review, see Denaro et al, 2020 ) and include the inhibition of the virus entry because of their permanent attachment on the virion envelope (Lin et al, 2011 ) or the inhibition of the enzyme responsible for the virus replication (Nutan et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs

Tito¹,

Colantuono²,

Pirone

et al. 2021

Front. Chem.

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Plant extracts are rich in bioactive compounds, such as polyphenols, sesquiterpenes, and triterpenes, which potentially have antiviral activities. As a consequence of the coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, thousands of scientists have been working tirelessly trying to understand the biology of this new virus and the disease pathophysiology, with the main goal of discovering effective preventive treatments and therapeutic agents. Plant-derived secondary metabolites may play key roles in preventing and counteracting the rapid spread of SARS-CoV-2 infections by inhibiting the activity of several viral proteins, in particular those involved in the virus entry into the host cells and its replication. Using in vitro approaches, we investigated the role of a pomegranate peel extract (PPE) in attenuating the interaction between the SARS-CoV-2 Spike glycoprotein and the human angiotensin-converting enzyme 2 receptor, and on the activity of the virus 3CL protease. Although further studies will be determinant to assess the efficacy of this extract in vivo, our results opened new promising opportunities to employ natural extracts for the development of effective and innovative therapies in the fight against SARS-CoV-2.

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“…[85][86][87] The antiviral action of some polyphenols has been reported against the Epstein-Barr virus, 88 enterovirus, 89 HSV, 90 and influenza virus. 91 Several studies on the action of polyphenols against SARS-CoV-2 have also been conducted using curcumin, kaempferol, catechin, naringenin, quercetin, hesperidin, rutin, and diosmin. 92,93 Methodology Tito et al 94 verified the potential of pomegranate peel extract (PPE) inhibit in vitro the interaction of the SARS-CoV-2 spike protein with its ACE2 receptor, and consequently, the entry of the coronavirus in the host cell.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Antiviral activity of medicinal plant-derived products against SARS-CoV-2

Oliveira

Antunes

Nascimento

et al. 2022

Exp Biol Med (Maywood)

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This review presents information from several studies that have demonstrated the antiviral activity of extracts ( Andrographis paniculata, Artemisia annua, Artemisia afra, Cannabis sativa, Curcuma longa, Echinacea purpurea, Olea europaea, Piper nigrum, and Punica granatum) and phytocompounds derived from medicinal plants (artemisinins, glycyrrhizin, and phenolic compounds) against SARS-CoV-2. A brief background of the plant products studied, the methodology used to evaluate the antiviral activity, the main findings from the research, and the possible mechanisms of action are presented. These plant products have been shown to impede the adsorption of SARS-CoV-2 to the host cell, and prevent multiplication of the virus post its entry into the host cell. In addition to antiviral activity, the plant products have also been demonstrated to exert an immunomodulatory effect by controlling the excessive release of cytokines, which is commonly associated with SARS-CoV-2 infections.

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Correction: Polygonum cuspidatum and Its Active Components Inhibit Replication of the Influenza Virus through Toll-Like Receptor 9-Induced Interferon Beta Expression

Cited by 18 publications

References 1 publication

Cell Clearing Systems as Targets of Polyphenols in Viral Infections: Potential Implications for COVID-19 Pathogenesis

Cell Clearing Systems as Targets of Polyphenols in Viral Infections: Potential Implications for COVID-19 Pathogenesis

Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs

Antiviral activity of medicinal plant-derived products against SARS-CoV-2

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