Correction: Recombinant Yellow Fever Viruses Elicit CD8<sup>+</sup>T Cell Responses and Protective Immunity against Trypanosoma cruzi

Nogueira, Raquel Tayar; Nogueira, Alanderson Rocha; Pereira, Mirian Cláudia de Souza; Rodrigues, MaurÃ­cio Martins; Neves, PatrÃ­cia Cristina da Costa; Galler, Ricardo; Bonaldo, Myrna C.

doi:10.1371/annotation/39b41d98-b117-41cf-b5de-b8486a67b1cd

Cited by 12 publications

(4 citation statements)

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“…ZIKV-specific CD8 T cells are described in multiple species ( Elong Ngono et al, 2017 ; Grifoni et al, 2018 ; Huang et al, 2017 ; Pardy et al, 2017 ) and may be important for viral clearance in mouse models. CD8 T cells have active roles in controlling infections caused by other flaviviruses including West Nile virus ( Grifoni et al, 2018 ; Klein et al, 2005 ; Shrestha and Diamond, 2004 ; Shrestha et al, 2006 ; Wang et al, 2003 , 2006 ), DENV ( de Alwis et al, 2016 ; Lam et al, 2017 ; Regla-Nava et al, 2018 ; Rivino and Lim, 2017 ; Shi et al, 2015 ; Yauch et al, 2009 ), and yellow fever virus ( Akondy et al, 2009 ; Bassi et al, 2015 ; Co et al, 2009 ; Nogueira et al, 2013 ), which, given their relatedness, implies that CD8 T cells may be similarly important in limiting ZIKV infection.…”

Section: Discussionmentioning

confidence: 99%

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells

et al. 2021

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While T cell immunity is an important component of the immune response to Zika virus (ZIKV) infection generally, the efficacy of these responses during pregnancy remains unknown. Here, we tested the capacity of CD8 lymphocytes to protect from secondary challenge in four macaques, two of which were depleted of CD8 + cells prior to rechallenge with a heterologous ZIKV isolate. The initial challenge during pregnancy produced transcriptional signatures suggesting complex patterns of immune modulation as well as neutralizing antibodies that persisted until rechallenge, which all animals efficiently controlled, demonstrating that the primary infection conferred adequate protection. The secondary challenge promoted activation of innate and adaptive immune cells, possibly suggesting a brief period of infection prior to clearance. These data confirm that ZIKV infection during pregnancy induces sufficient immunity to protect from a secondary challenge and suggest that this protection is not dependent on CD8 T cells.

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Section: Discussionmentioning

confidence: 99%

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells

et al. 2021

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“…If infection cannot be avoided, a prophylactic vaccine should induce a substantial decrease in parasite burden in tissues, which will eventually diminish morbidity and mortality rates. In recent years, special attention has been paid to the use of glycoantigens, chimeric antigens, novel adjuvants, and live platforms (Nogueira et al, 2013;Sanchez Alberti et al, 2017;Portillo et al, 2019;Bivona et al, 2020;Lokugamage et al, 2021;Rodrigues da Cunha et al, 2021;Cai et al, 2022;Pacini et al, 2022). Recently, Jha et al (2023) demonstrated that a parasite attenuated by the deletion of cyclophilin-19 completely prevents T. cruzi infection.…”

Section: Discussionmentioning

confidence: 99%

Vaccination with parasite-specific TcTASV proteins combined with recombinant baculovirus as a delivery platform protects against acute and chronic Trypanosoma cruzi infection

Masip,

Caeiro,

Cosenza

et al. 2024

Front. Cell. Infect. Microbiol.

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Chagas’ is a neglected disease caused by the eukaryotic kinetoplastid parasite, Trypanosoma cruzi. Currently, approximately 8 million people are infected worldwide, most of whom are in the chronic phase of the disease, which involves cardiac, digestive, or neurologic manifestations. There is an urgent need for a vaccine because treatments are only effective in the initial phase of infection, which is generally underdiagnosed. The selection and combination of antigens, adjuvants, and delivery platforms for vaccine formulations should be designed to trigger mixed humoral and cellular immune responses, considering that T. cruzi has a complex life cycle with both intracellular and bloodstream circulating parasite stages in vertebrate hosts. Here, we report the effectiveness of vaccination with a T. cruzi-specific protein family (TcTASV), employing both recombinant proteins with aluminum hydroxide and a recombinant baculovirus displaying a TcTASV antigen at the capsid. Vaccination stimulated immunological responses by producing lytic antibodies and antigen-specific CD4+ and CD8+ IFNɣ secreting lymphocytes. More than 90% of vaccinated animals survived after lethal challenges with T. cruzi, whereas all control mice died before 30 days post-infection. Vaccination also induced a strong decrease in chronic tissue parasitism and generated immunological memory that allowed vaccinated and infected animals to control both the reactivation of the infection after immunosuppression and a second challenge with T. cruzi. Interestingly, inoculation with wild-type baculovirus partially protected the mice against T. cruzi. In brief, we demonstrated for the first time that the combination of the baculovirus platform and the TcTASV family provides effective protection against Trypanosoma cruzi, which is a promising vaccine for Chagas disease.

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“…17D is also being used as a vector for the delivery of foreign antigens against the related dengue virus, and this approach has been licensed in Mexico. 17D continues to be developed for the delivery of novel antigens aimed at protection against other pathogens like human immunodeficiency virus (HIV), malaria, trypanosomes and the Lassa virus [17,18,19,20,21]. The risk of SAE in these chimeric 17D viruses remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…17D, arguably, sits at the pinnacle of vaccine success, alongside those for small pox and polio. The importance of 17D remains high as a reverse genetics system [16] has made the vaccine a vector for other antigens [17,18,19,20,21] and a backbone for the development of vaccines against other flaviviruses, specifically [22]. The highly efficacious and long-lasting immunity elicited by the 17D makes it an important target of future research for the development of vaccines against related viruses and the understanding attenuation and immune inductive processes for highly efficacious vaccines in general [23].…”

Section: Yellow Fever Virus: History Legacy and Futurementioning

confidence: 99%

T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models

Watson

Klimstra

2017

Viruses

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The 17D line of yellow fever virus vaccines is among the most effective vaccines ever created. The humoral and cellular immunity elicited by 17D has been well characterized in humans. Neutralizing antibodies have long been known to provide protection against challenge with a wild-type virus. However, a well characterized T cell immune response that is robust, long-lived and polyfunctional is also elicited by 17D. It remains unclear whether this arm of immunity is protective following challenge with a wild-type virus. Here we introduce the 17D line of yellow fever virus vaccines, describe the current state of knowledge regarding the immunity directed towards the vaccines in humans and conclude with a discussion of animal models that are useful for evaluating T cell-mediated immune protection to yellow fever virus.

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Correction: Recombinant Yellow Fever Viruses Elicit CD8⁺T Cell Responses and Protective Immunity against Trypanosoma cruzi

Cited by 12 publications

References 0 publications

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells

Vaccination with parasite-specific TcTASV proteins combined with recombinant baculovirus as a delivery platform protects against acute and chronic Trypanosoma cruzi infection

T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models

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Correction: Recombinant Yellow Fever Viruses Elicit CD8+T Cell Responses and Protective Immunity against Trypanosoma cruzi

Cited by 12 publications

References 0 publications

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells

Vaccination with parasite-specific TcTASV proteins combined with recombinant baculovirus as a delivery platform protects against acute and chronic Trypanosoma cruzi infection

T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models

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About

Correction: Recombinant Yellow Fever Viruses Elicit CD8⁺T Cell Responses and Protective Immunity against Trypanosoma cruzi