Correction: The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine

Jung, Deok Beom; Yun, Miyong; Kim, Yang Soo; Kim, Jae Kwang; Kim, Bonglee; Jung, Ji Hoon; Wang, Enfeng; Mukhopadhyay, Debabrata; Hammond, Edward; Dredge, Keith; Shridhar, Viji; Kim, Sung Hoon

doi:10.18632/oncotarget.27216

Cited by 1 publication

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“…Consistently, upregulation of HPSE increase Wnt expression, which promotes invasiveness, metastasis, and dedifferentiation of colon cancer cells (Katakam et al, 2020). However, PG545 treatment exerts antitumor effects by blocking Wnt/β‐catenin signalig, which is also considered as a potential cancer treatment strategy (Jung et al, 2019; Figure 3).…”

Section: The Protumorigenic Role Of Hpse In Cancer Progressionmentioning

confidence: 99%

“…However, PG545 treatment exerts antitumor effects by blocking Wnt/β-catenin signalig, which is also considered as a potential cancer treatment strategy (Jung et al, 2019; Figure 3).…”

Section: Hpse Activating Wnt Signalingmentioning

confidence: 99%

“…Intriguingly, PG545 is also a novel immunomodulator that stimulates the innate immune response against advanced solid tumors (Dredge et al, 2018). Previous studies have shown that PG545 exhibits antiangiogenic and antimetastatic activity in vivo, as well as potent antitumor activity in several preclinical models resistant to PI-88 treatment (Jung et al, 2019;Ostapoff et al, 2013). A detailed study on the efficacy of PG545 in a mouse lymphoma model demonstrates that its antitumor effects was dependent on the activation of natural killer (NK) cells, which in turn required the involvement of Toll-like receptor 9 (Brennan et al, 2016).…”

Section: Pg545mentioning

confidence: 99%

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Potential roles of heparanase in cancer therapy: Current trends and future direction

Yang

Yuan

Zhou

et al. 2023

Journal Cellular Physiology

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Heparanase (HPSE; heparanase‐1) is an endo‐β‐glucuronidase capable of degrading the carbohydrate moiety of heparan sulfate proteoglycans, thus modulating and facilitating the remodeling of the extracellular matrix and basement membrane. HPSE activity is strongly associated with major human pathological complications, including but not limited to tumor progress and angiogenesis. Several lines of literature have shown that overexpression of HPSE leads to enhanced tumor growth and metastatic transmission, as well as poor prognosis. Gene silencing of HPSE or treatment of tumor with compounds that block HPSE activity are shown to remarkably attenuate tumor progression. Therefore, targeting HPSE is considered as a potential therapeutical strategy for the treatment of cancer. Intriguingly, recent findings disclose that heparanase‐2 (HPSE‐2), a close homolog of HPSE but lacking enzymatic activity, can also regulate antitumor mechanisms. Given the pleiotropic roles of HPSE, further investigation is in demand to determine the precise mechanism of regulating action of HPSE in different cancer settings. In this review, we first summarize the current understanding of HPSE, such as its structure, subcellular localization, and tissue distribution. Furthermore, we systematically review the pro‐ and antitumorigenic roles and mechanisms of HPSE in cancer progress. In addition, we delineate HPSE inhibitors that have entered clinical trials and their therapeutic potential.

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Section: The Protumorigenic Role Of Hpse In Cancer Progressionmentioning

confidence: 99%

“…However, PG545 treatment exerts antitumor effects by blocking Wnt/β-catenin signalig, which is also considered as a potential cancer treatment strategy (Jung et al, 2019; Figure 3).…”

Section: Hpse Activating Wnt Signalingmentioning

confidence: 99%