Correction to: Hetero-bivalent agents targeting FAP and PSMA

Srikanth, B.; Lisok, Alla; Lofland, Gabriela; Minn, Il; Yan, Yu; Jiang, Zirui; Shin, Min Jay; Merino, Vanessa F.; Li, Zheng; Brayton, Cory; Pomper, Martin G.; Banerjee, Sangeeta Ray

doi:10.1007/s00259-022-05951-1

Cited by 2 publications

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“…A recent proteomic study on PCa para n-embedded (FFPE) tissue samples showed that protein VCAN is associated with biochemical recurrence of PCa, could be a prognostic marker (Lygirou et al 2022). another study con rmed that FAP has potential as a diagnostic and therapeutic target, and PCa tissue could be better visualized in positron emission tomography/computed tomography (PET/CT) using a developer targeting FAP (Boinapally et al 2022). In addition, previous in vitro studies con rmed that 1upregulating SFRP in PCa cell lines could induced epithelial-mesenchymal transformation (EMT), transform PCa cells into osteoblast-like phenotypes that conducive to survival in bone metastases (Kato et al 2019).…”

Section: Discussionmentioning

confidence: 97%

Identification of prognostic signature of cancer-associated fibroblasts associated with castration resistance prostate cancer based on Weighted Gene Co-expression Network Analysis

Zhang

Che

Liu

et al. 2023

Preprint

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Prostate cancer (PCa) is the most common cancer in men and often progresses to castration resistant prostate cancer (CRPC) after treatment, with a poor prognosis. Cancer associated fibroblasts (CAF) are a major components of tumor microenvironment (TME), which participate in angiogenesis and immunosuppression, promote metastasis and treatment drug resistance. In order to identify the CAF prognostic genes associated with CRPC, the RNA sequencing data of 745 PCa patients from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were downloaded. The CAF-related hub genes were identified by weighted gene co-expression network analysis (WCGNA). The CAF prognostic markers (FAP, SFRP2, COL1A1, VCAN) and signature were developed by machine learning methodology. Meanwhile, verified the CAF prognostic model could predict biochemical recurrence, metastasis and immunotherapy response. In addition, CAF infiltration was associated with immunosuppressive microenvironment, positively correlated with tumor mutation burden and “p53 downstream pathway”, “MET promotes cell motility pathway” and “TGF- β signal pathway”. subsequently, verified the CAF prognostic markers (FAP, SFRP2, COL1A1, VCAN) were specifically expressed in fibroblast cell lines, and the protein expression were located in stromal cells. In conclusion, these results indicated that CAF infiltration promoted the progression of PCa and associated with PCa recurrence and poor prognosis. The PCa prognostic signature has a potential clinical application value and the prognostic markers in CAF might be targets for inhibiting the progression of PCa.

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Section: Discussionmentioning

confidence: 97%

Identification of prognostic signature of cancer-associated fibroblasts associated with castration resistance prostate cancer based on Weighted Gene Co-expression Network Analysis

Zhang

Che

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Polymeric peptides constructed on the basis of the polyvalent effect can improve the tumor-targeting ability and prolong tumor retention time remarkably. Plenty of polymerized peptides have been reported previously, and polymerization can be performed between the same peptides, such as 2P(RGD) 2 [33] and 2P(FAPI) [24], or between two kinds of peptides, for example, PSMA-FAPI [34] and RGD-FAPI [35]. According to current clinical data, based on polymerization strategy, 2P(RGD) 2 and 2P(FAPI) have been constructed and testified to gain an increased tumor uptake rate and better tumor retention capacity.…”

Section: Discussionmentioning

confidence: 99%

Imageological/Structural Study regarding the Improved Pharmacokinetics by 68Ga-Labeled PEGylated PSMA Multimer in Prostate Cancer

et al. 2023

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PMSA (prostate-specific membrane antigen) is currently the most significant target for diagnosing and treating PCa (prostate cancer). Herein, we reported a series 68Ga/177Lu-labeled multimer PSMA tracer conjugating with PEG chain, including [68Ga]Ga-DOTA-(1P-PEG4), [68Ga]Ga-DOTA-(2P-PEG0), [68Ga]Ga-DOTA-(2P-PEG4), and [68Ga]Ga/[177Lu]Lu-DOTA-(2P-PEG4)2, which showed an advantage of a multivalent effect and PEGylation to achieve higher tumor accumulation and faster kidney clearance. To figure out how structural optimizations based on a PSMA multimer and PEGylation influence the probe’s tumor-targeting ability, biodistribution, and metabolism, we examined PSMA molecular probes’ affinities to PC-3 PIP (PSMA-highly-expressed PC-3 cell line), and conducted pharmacokinetics analysis, biodistribution detection, small animal PET/CT, and SPECT/CT imaging. The results showed that PEG4 and PSMA dimer optimizations enhanced the probes’ tumor-targeting ability in PC-3 PIP tumor-bearing mice models. Compared with the PSMA monomer, the PEGylated PSMA dimer reduced the elimination half-life in the blood and increased uptake in the tumor, and the biodistribution results were consistent with PET/CT imaging results. [68Ga]Ga-DOTA-(2P-PEG4)2 exhibited higher tumor-to-organ ratios. When labeled by lutetium-177, relatively high accumulation of DOTA-(2P-PEG4)2 was still detected in PC-3 PIP tumor-bearing mice models after 48 h, indicating its prolonged tumor retention time. Given the superiority in imaging, simple synthetic processes, and structural stability, DOTA-(2P-PEG4)2 is expected to be a promising tumor-targeting diagnostic molecular probe in future clinical practice.

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Correction to: Hetero-bivalent agents targeting FAP and PSMA

Abstract: This article is part of the Topical Collection on Erratum.

Cited by 2 publications

References 0 publications

Identification of prognostic signature of cancer-associated fibroblasts associated with castration resistance prostate cancer based on Weighted Gene Co-expression Network Analysis

Identification of prognostic signature of cancer-associated fibroblasts associated with castration resistance prostate cancer based on Weighted Gene Co-expression Network Analysis

Imageological/Structural Study regarding the Improved Pharmacokinetics by 68Ga-Labeled PEGylated PSMA Multimer in Prostate Cancer

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