Correction to: Identifying and Characterizing Trans Women in the Swiss HIV Cohort Study as an Epidemiologically Distinct Risk Group

Nguyen, Huyen; Hampel, Benjamin; Nuñez, David Garcia; Battegay, Manuel; Hachfeld, Anna; Bernasconi, Enos; Calmy, Alexandra; Cavassini, Matthias; Vernazza, Pietro; Fellay, Jacques; Rudolph, Hannes; Huber, Michael; Leuzinger, Karoline; Perreau, Matthieu; Scherrer, Alexandra U.; Ramette, Alban; Yerly, Sabine; Günthard, Huldrych F.; Kouyos, Roger D.; Kusejko, Katharina

doi:10.1093/cid/ciac242

Cited by 2 publications

(5 citation statements)

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“…As previously described (33), TW in the SHCS were more likely to be of Asian and Hispano-American ethnicity compared to CW and had overall similar education levels as CW (Table 1). A higher proportion of TW had ever taken sex hormones compared to CW (69.9% versus 18.9%).…”

Section: Study Populationmentioning

confidence: 60%

“…We identified 86 TW -using criteria previously described (33), and 3'165 CW with at least one laboratory measurement after January 1 st , 2015.…”

Section: Cis and Trans Women In The Shcsmentioning

confidence: 99%

“…Trans women (TW, referring to people who were recorded male at birth but do not identify with being a man) are disproportionally affected by HIV-1 (31,32) and constitute a distinct epidemiologic group compared to men having sex with men and cis women (32)(33)(34). TW are still under-represented in HIV-1 research; therefore, little is known on the immune effect of sex hormone intake in TW and more generally on the effect of hormonal therapy taken by TW on HIV-1 suppression and longer-term health outcomes (35)(36)(37)(38).…”

Section: Introductionmentioning

confidence: 99%

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Delineating the effect of sex hormone intake on immunity in cis and trans women with HIV

Pasin

Nuñez

Kusejko

et al. 2023

Preprint

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BackgroundAlthough sex hormones are recognized to induce immune variations, little is known on the effect of exogenous sex hormone intake on immune responses in cis and trans women. Here, we aimed at quantifying how sex hormone intake affects HIV-1 immune markers in cis women (CW) and trans women (TW) with HIV.MethodsWe considered measurements of key HIV-1 immune markers (CD4, CD8, lymphocyte counts, and CD4:CD8 ratio) from cis men (CM), CW, and TW enrolled in the Swiss HIV Cohort Study. We modeled immune markers using linear mixed-effects models with an interaction between the variables “group” (CW, TW) and “with sex hormone intake” (yes/no). We conducted serum proteomics measurements of 92 inflammation markers on samples from 31 TW before and after sex hormone intake to assess the inflammation environment.ResultsWe included 54’141 measurements from 3’092 CW and 83 TW sampled between 2015 and 2022, and 147’298 from 8’611 CM. Sex hormone intake was associated with significant distinct effects on CD4 and CD4:CD8 ratio between the different groups of women (p=0.0025 and 0.015). TW with sex hormone intake had significantly higher CD4 counts (median = 772 (1Q-3Q=520-1’006)) than without (median = 617 (1Q-3Q=426-892)). This increase was similar in magnitude to the difference in CD4 counts between CW and CM. None of the serum inflammation proteins showed significant concentration difference before and after sex hormone intake in TW.ConclusionThis study highlights the need to consider the potential role of sex hormone intake in modulating the immune system among other biological and social factors, especially in TW in HIV.

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Section: Study Populationmentioning

confidence: 60%

“…We identified 86 TW -using criteria previously described (33), and 3'165 CW with at least one laboratory measurement after January 1 st , 2015.…”

Section: Cis and Trans Women In The Shcsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Delineating the effect of sex hormone intake on immunity in cis and trans women with HIV

Pasin

Nuñez

Kusejko

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the Swiss HIV Cohort Study, for example, transgender women experienced twice the rates of previous psychological-related hospitalization than cisgender women (11.2% versus 5.1%). 44 However, there are limited studies in this area. Hence, the state of science on transgender women underscores the need for research to focus on HIV prevention and care among this population.…”

Section: Discussionmentioning

confidence: 99%

“…43 Despite the burden of HIV among transgender women, there is a paucity of data about this population. 44 For instance, only one transgender women U.S. study 7 with a focus on this research area was found during the literature search. The study was excluded due to limited data on levels in gender transition (such as hormone, surgery, or full transition) and factors associated with viral suppression in different stages in gender transition.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with viral suppression among cisgender women living with human immunodeficiency virus in the United States: An integrative review

Labisi

Podany

Fadul

et al. 2022

Womens Health (Lond Engl)

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Introduction: Women account for 23% of new human immunodeficiency virus diagnoses in the United States, yet remain understudied. Adherence to antiretroviral therapy and consequent viral suppression are keys to preventing human immunodeficiency virus transmission, reducing risk of drug resistance, and improving health outcomes. Objectives: This review identified and synthesized peer-reviewed studies in the United States describing factors associated with viral suppression among cisgender women living with human immunodeficiency virus. Methods: We searched five databases: Cumulative Index to Nursing and Allied Health (CINAHL), PubMed, Embase, Scopus, and PsycINFO, and reported the findings using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Eligible studies included: (1) peer-reviewed English-language articles published since 2010; (2) includes only cisgender women; (3) participants were at least 18 years of age; (4) reported metrics on viral loads; and (5) conducted in the United States. Results: Fourteen studies in total were reviewed. Eight studies had adult women living with human immunodeficiency virus, four recruited only pregnant women, and two included only racial minority women. The most commonly reported factors negatively associated with viral suppression were substance use ( n = 4), followed by availability of health insurance, financial constraint, complexity of human immunodeficiency virus treatment regimen ( n = 3), and intimate partner violence ( n = 2). Other factors were depression, race, and age. In addition, all four studies that included only pregnant women reported early human immunodeficiency virus care engagement as a significant predictor of low viral loads pre- and post-partum. Conclusion: Substance use, financial constraint, lack of health insurance, human immunodeficiency virus treatment regimen type, intimate partner violence, and late human immunodeficiency virus care pre–post pregnancy were the most common factors negatively associated with viral suppression. There is a paucity of data on viral suppression factors related to transgender and rural populations. More human immunodeficiency virus research is needed to explore factors associated with human immunodeficiency virus treatment outcomes in transgender women and cisgender women in rural U.S. regions.

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Correction to: Identifying and Characterizing Trans Women in the Swiss HIV Cohort Study as an Epidemiologically Distinct Risk Group

Cited by 2 publications

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Delineating the effect of sex hormone intake on immunity in cis and trans women with HIV

Delineating the effect of sex hormone intake on immunity in cis and trans women with HIV

Factors associated with viral suppression among cisgender women living with human immunodeficiency virus in the United States: An integrative review

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