Correction to: Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca2+-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells

Choi, Ae Jin; Choi, Ji Hyun; Hwang, Keun-Young; Jeong, Yeon Ju; Choe, Wonchae; Yoon, Kyung‐Sik; Ha, Joohun; Kim, Sung Soo; Youn, Jang H.; Yeo, Eui‐Ju; Kang, Insug

doi:10.1007/s10495-018-1493-4

Cited by 6 publications

(5 citation statements)

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“…Moreover, the number of early apoptotic cells was also reduced by CHOP siRNA compared to the H 2 O 2 and NC siRNA groups, and the cell survival was improved. These data were consistent to the CHOP −/− knockout model in vivo (21,43,44). Furthermore, the correlation analysis revealed that CHOP mRNA was positively correlated with PERK, 17 kD active caspase-3 and HMGB-1, and apoptosis, but negatively related to cell viability.…”

Section: Discussionsupporting

confidence: 85%

“…Therefore, our data demonstrated that CHOP involved in renal IR-related and IR injuries, and CHBP-induced renoprotection might be through regulating CHOP or improving ERS. However, when UPR response cannot restore the homeostasis of endoplasmic reticulum upon IR injury, PERK pathway could trigger off downstream apoptosis via the activation of CHOP, caspase-12 and Bcl-2 family (44,47,48). Additional correlation analysis revealed that CHOP protein was positively correlated with the level of TID and active caspase-3 protein at 2 weeks.…”

Section: Discussionmentioning

confidence: 97%

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Erythropoietin Derived Peptide Improved Endoplasmic Reticulum Stress and Ischemia-Reperfusion Related Cellular and Renal Injury

et al. 2020

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 97%

Erythropoietin Derived Peptide Improved Endoplasmic Reticulum Stress and Ischemia-Reperfusion Related Cellular and Renal Injury

et al. 2020

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“…LicoA had no significant toxic effect to Vero cells at the evaluated concentrations. Minimal toxicity has been also reported for other mammalian cell lines such as Chang normal human liver cells by Choi et al (6) and CHO-K1 cells by Souza et al (23). Taken together, our promising results in vitro and the absence of cytotoxicity encouraged us to further investigate LicoA anti-schistosomal effects in animal models.…”

Section: Number Of Animals Average Of Worms ± Sedsupporting

confidence: 75%

The flavonoid Licochalcone A induces tegumental damages in Schistosoma mansoni and impairs its oviposition in vitro

Felicissimo¹,

Marconato²,

Emídio³

et al. 2021

BJVP

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In this study, Licochalcone A (LicoA) was investigated in in vitro and in vivo assays. The survival of worms in culture, the pattern of oviposition, the count of intact tubers and the integrity of the coat were adopted in the in vitro tests. After the animals were perfused, the number of worms recovered, their location and the oogram study were the parameters analyzed to signal the existence of potential schistosomicidal activity in vivo. We observed reduction on the survival, integument integrity and reproduction of adult worms in vitro. Murine models did not show a significant difference in the parasitological parameters analyzed that indicate activity against the worms with an oral single dose of 25 mg/ kg of LicoA or two intraperitoneal injection of 50 mg/ kg LicoA. Nevertheless, it is too early to completely exclude the schistosomicide activity of LicoA, considering that the used dosage form could not provide a regular absorption of the drug.

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“…The anticancer role of LicA has been widely studied in various cancer studies. LicA has been shown to inhibit the proliferation and induce the apoptosis of cancer cells in multiple ways, such as regulating reactive oxygen species (ROS)‐mediated signaling pathways, 7,8 modulating bcl‐2 protein expression, 9,10 arresting cell cycle progression, 6,11 and triggering mitochondrial dysfunction 12 . In addition, LicA has been shown to suppress tumor metastasis as a promising antimetastatic agent 13,14 …”

Section: Introductionmentioning

confidence: 99%

Licochalcone A inhibits cell growth through the downregulation of the Hippo pathway via PES1 in cholangiocarcinoma cells

Miao

et al. 2021

Environmental Toxicology

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Overexpression or activation of Yes‐associated protein (YAP) is common in cancer cells. Thus, targeting YAP may be a strategy for cancer therapy. Licochalcone A (LicA) is a primary active compound of licorice root and is known to have medicinal effects, such as antioxidant, antibacterial, antiviral, and anticancer effects. However, the anticancer pharmacological mechanism of LicA has not been investigated in cholangiocarcinoma. In this study, we investigated the antiproliferative effect of LicA and the underlying molecular mechanism in HCCC‐9810 and RBE human cholangiocarcinoma cells. Our experiments indicated that LicA suppressed the growth of cholangiocarcinoma cells through inactivation of the Hippo pathway. Pescadillo ribosomal biogenesis factor 1 (PES1) was notably upregulated and related to carcinogenesis. We also found that LicA suppressed the expression and nuclear localization of PES1, which was associated with the inhibition of YAP expression and transcriptional activity.

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Correction to: Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca2+-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells

Cited by 6 publications

References 0 publications

Erythropoietin Derived Peptide Improved Endoplasmic Reticulum Stress and Ischemia-Reperfusion Related Cellular and Renal Injury

Erythropoietin Derived Peptide Improved Endoplasmic Reticulum Stress and Ischemia-Reperfusion Related Cellular and Renal Injury

The flavonoid Licochalcone A induces tegumental damages in Schistosoma mansoni and impairs its oviposition in vitro

Licochalcone A inhibits cell growth through the downregulation of the Hippo pathway via PES1 in cholangiocarcinoma cells

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