Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

Clayton, Kevin; Delpech, Jean-Christophe; Herron, Shawn; Iwahara, Naotoshi; Ericsson, Maria; Saito, Takashi; Saido, Takaomi C.; Ikezu, Seiko; Ikezu, Tsuneya

doi:10.1186/s13024-021-00447-2

Cited by 8 publications

(4 citation statements)

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“…Neurons absorb p-tau contained in EVs and trigger abnormal aggregation of tau protein. Moreover, tau propagation slows down-regulated when microglia are consumed, which is consistent with their previous findings ( Clayton et al, 2021 ).…”

Section: Role Of Glia-derived Extracellular Vesicles In Neurodegenerative Diseasessupporting

confidence: 92%

Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases

Tan

Song

et al. 2021

Front. Aging Neurosci.

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Extracellular vesicles (EVs), as nano-sized vesicles secreted by almost all cells, have been recognized as the essential transmitter for cell-to-cell communication and participating in multiple biological processes. Neurodegenerative diseases (ND), such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, share common mechanisms of the aggregation and propagation of distinct pathologic proteins among cells in the nervous systems and neuroinflammatory reactions mediated by glia during the pathogenic process. This feature indicates the vital role of crosstalk between neurons and glia in the pathogenesis of ND. In recent years, glia-derived EVs have been investigated as potential mediators of signals between neurons and glia, which provides a new direction and strategy for understanding ND. By a comprehensive summary, it can be concluded that glia-derived EVs have both a beneficial and/or a detrimental effect in the process of ND. Therefore, this review article conveys the role of glia-derived EVs in the pathogenesis of ND and raises current limitations of their potential application in the diagnosis and treatment of ND.

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Section: Role Of Glia-derived Extracellular Vesicles In Neurodegenerative Diseasessupporting

confidence: 92%

Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases

Tan

Song

et al. 2021

Front. Aging Neurosci.

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“…This AD mice model exhibited robust senile plaque formation suggesting a new potential mechanism that links Aβ deposition and p-Tau spreading (Clayton et al, 2021). It was also found that EVs from rTg4510 mice brain extracellular space were able to seed Tau aggregation by inducing endolysosomal permeabilization (Polanco et al, 2021).…”

Section: Brain Tissuementioning

confidence: 79%

“…Regarding the isolation methods, UC is by far the most used in EVs with exosome-like characteristics secreted from cellular models (Asai et al, 2015;Bai et al, 2021;Beretta et al, 2020;Bodart-Santos et al, 2019;Candelario et al, 2020;Chen et al, 2020;Delenclos et al, 2017;Ding et al, 2022;Dou et al, 2021;Eitan et al, 2016;Emmanouilidou et al, 2010;Grey et al, 2015;Gustafsson et al, 2018;Harischandra et al, 2018;Harischandra et al, 2019;Imanbekova et al, 2021;Izadpanah et al, 2020;Koinuma et al, 2021;Lauritzen et al, 2019;Marzano et al, 2019;Meng et al, 2020;Micci et al, 2019;Nikitidou et al, 2017;Park et al, 2020;Santa-Maria et al, 2012;Tang et al, 2022;Vrancx et al, 2021;Wang et al, 2012;Wei et al, 2020;Willén et al, 2017;Yang et al, 2020;Yuyama et al, 2019;Zarrin et al, 2021;Zhang, Xu, et al, 2020), whereas dgUC was employed in EVs isolation derived from brain tissue in nearly all studies presented (Asai et al, 2015;Cheng et al, 2020;Clayton et al, 2021;Cohn et al, 2021;Ding et ...…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

Extracellular vesicles in the study of Alzheimer's and Parkinson's diseases: Methodologies applied from cells to biofluids

Vaz

Martins

Henriques

2022

Journal of Neurochemistry

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Extracellular vesicles (EVs) are gaining increased importance in fundamental research as key players in disease pathogenic mechanisms, but also in translational and clinical research due to their value in biomarker discovery, either for diagnostics and/or therapeutics. In the first research scenario, the study of EVs isolated from neuronal models mimicking neurodegenerative diseases can open new avenues to better understand the pathological mechanisms underlying these conditions or to identify novel molecular targets for diagnosis and/or therapeutics. In the second research scenario, the easy availability of EVs in body fluids and the specificity of their cargo, which can reflect the cell of origin or disease profiles, turn these into attractive diagnostic tools. EVs with exosome‐like characteristics, circulating in the bloodstream and other peripheral biofluids, constitute a non‐invasive and rapid alternative to study several conditions, including brain‐related disorders. In both cases, several EVs isolation methods are already available, but each neuronal model or biofluid presents its own challenges. Herein, a literature overview on EVs isolation methodologies from distinct neuronal models (cellular culture and brain tissue) and body fluids (serum, plasma, cerebrospinal fluid, urine and saliva) was carried out. Focus was given to approaches employed in the context of Alzheimer's and Parkinson's diseases, and the main research findings discussed. The topics here revised will facilitate the choice of EVs isolation methodologies and potentially prompt new discoveries in EVs research and in the neurodegenerative diseases field.

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“…The injection speed was 500 nl min-1. To allow siRNA spreading and avoid spillage, the injector was left in the injection site for at least 5 min ( Clayton et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Development of NMDA receptors contributes to the enhancement of electroencephalogram oscillations under volatile anesthetics in rats

Zhang

Chen

Liu

et al. 2022

Front. Neural Circuits

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BackgroundVolatile anesthetics including sevoflurane and isoflurane enhance oscillations of cortical electroencephalogram (EEG), partly by their modulations on glutamate-mediated excitatory synaptic transmission. Expression of NMDA receptors is increased during neonatal development. However, how the development of NMDA receptors influences EEG under volatile anesthesia remains unclear.MethodsExpressions of NMDA receptor subtypes (NR1, NR2A, and NR2B) during neonatal development were measured by Western blotting. MAC (minimal alveolar concentration) of isoflurane and sevoflurane that inducing loss of righting reflex (LORR) and no response to tail-clamp (immobility) were measured to verify the effect of NR1 expression on anesthetic potency during neonatal development. Cortical electroencephalogram recording was used to examine the influence of NR1 expression on the power density of EEG.ResultsThe expressions of GluNR1, GluNR2A and GluNR2B receptors were gradually increased during neonatal development in cortex, hippocampus and thalamus of rats. Knockdown of NR1 enhanced the sedative potency of volatile anesthetics but not on immobility potency in postnatal day 14 (P14)-P17 rats. For cortical EEG, along with the increased concentration of volatile anesthetics, cortical slow-delta oscillations of P5 rats were inhibited, theta and alpha oscillations were not changed significantly; while these oscillations were enhanced until high anesthetic concentrations in P21 rats. Knockdown of NR1 in forebrain suppressed the enhancement of cortical EEG oscillations in P21 rats.ConclusionThe development of NMDA receptors may contribute to the enhancement of cortical EEG oscillations under volatile anesthetics.

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Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

Abstract: An amendment to this paper has been published and can be accessed via the original article.

Cited by 8 publications

References 1 publication

Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases

Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases

Extracellular vesicles in the study of Alzheimer's and Parkinson's diseases: Methodologies applied from cells to biofluids

Development of NMDA receptors contributes to the enhancement of electroencephalogram oscillations under volatile anesthetics in rats

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