Correction to: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

Mullaney, Jane A.; Stephens, J.; Costello, Mary-Ellen; Fong, Cai; Geeling, Brooke E.; Gavin, Patrick G.; Wright, Casey M.; Spector, Timothy D.; Brown, Matthew A.; Hamilton‐Williams, Emma E.

doi:10.1186/s40168-018-0438-z

Cited by 11 publications

(12 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A growing number of studies have supported the striking linking of altered microbiota composition with the onset of several different autoimmune disorders (Table 1). These include Type I diabetes (T1D) [16,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53]; rheumatoid arthritis (RA) [54,55,56,57,58,59,60,61,62]; systemic lupus erythematosus (SLE) [63,64,65,66,67]; inflammatory bowel disease (IBD) encompassing Crohn’s disease (CD) and ulcerative colitis (UC) [68,69,70,71,72,73,74,75,76,77,78]; Behcet’s disease (BD) [79,80,81,82]; autoimmune skin conditions including vitiligo [83], psoriasis vulgaris [84,85,86,87,88], and atopic dermatitis [89,90,91,92,93,…”

Section: Microbiome Composition and Autoimmune Conditionsmentioning

confidence: 99%

“…The sequencing of bacterial 16S rRNA gene highlighted that diet changes or antibiotic treatments disrupt ileal and cecal microbiota, with an enhancement in Firmicutes / Bacteriodetes ratio and in the relative abundances of lactobacilli and butyrate producing taxa [50]. A recent study of Mullaney et al [52] found that specific gut microbial imbalance were linked to T1D susceptibility alleles in mice. Accordingly, immune tolerance towards islet antigens was re-established upon disease protective allele introduction which induced a restoration of the gut immune regulatory system and microbiome modifications.…”

Section: Microbiome Composition and Autoimmune Conditionsmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances on Microbiota Involvement in the Pathogenesis of Autoimmunity

Gianchecchi

Fierabracci

2019

IJMS

View full text Add to dashboard Cite

Autoimmune disorders derive from genetic, stochastic, and environmental factors that all together interact in genetically predisposed individuals. The impact of an imbalanced gut microbiome in the pathogenesis of autoimmunity has been suggested by an increasing amount of experimental evidence, both in animal models and humans. Several physiological mechanisms, including the establishment of immune homeostasis, are influenced by commensal microbiota in the gut. An altered microbiota composition produces effects in the gut immune system, including defective tolerance to food antigens, intestinal inflammation, and enhanced gut permeability. In particular, early findings reported differences in the intestinal microbiome of subjects affected by several autoimmune conditions, including prediabetes or overt disease compared to healthy individuals. The present review focuses on microbiota-host homeostasis, its alterations, factors that influence its composition, and putative involvement in the development of autoimmune disorders. In the light of the existing literature, future studies are necessary to clarify the role played by microbiota modifications in the processes that cause enhanced gut permeability and molecular mechanisms responsible for autoimmunity onset.

show abstract

Section: Microbiome Composition and Autoimmune Conditionsmentioning

confidence: 99%

Section: Microbiome Composition and Autoimmune Conditionsmentioning

confidence: 99%

Recent Advances on Microbiota Involvement in the Pathogenesis of Autoimmunity

Gianchecchi

Fierabracci

2019

IJMS

View full text Add to dashboard Cite

show abstract

“…Recently published study found that oral penicillin can induce gut microbiota dysbiosis in mice, which may associate with host lipid metabolism dysfunction and low-grade inflammation 9 . As all known, the human gut microbiome has been confirmed to play a causal role in the development of pathologies in animal models of metabolic disease such as obesity, Alzheimer’s disease and Type 1 diabetes (T1D) 10 – 12 . The human gut microbiome participates in nutrient metabolism, inhibition of pathogenic growth, angiogenesis stimulation, and the maturation and maintenance of the immunological system to ensure a balance or homeostasis in the host 6 , 13 , 14 .…”

Section: Discussionmentioning

confidence: 99%

Altered diversity and composition of gut microbiota in Wilson's disease

Cai

Deng

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Wilson’s disease (WD) is an autosomal recessive inherited disorder of chronic copper toxicosis with high mortality and disability. Recent evidence suggests a correlation between dysbiosis in gut microbiome and multiple diseases such as genetic and metabolic disease. However, the impact of intestinal microbiota polymorphism in WD have not been fully elaborated and need to be explore for seeking some microbiota benefit for WD patients. In this study, the 16S rRNA sequencing was performed on fecal samples from 14 patients with WD and was compared to the results from 16 healthy individuals. The diversity and composition of the gut microbiome in the WD group were significantly lower than those in healthy individuals. The WD group presented unique richness of Gemellaceae, Pseudomonadaceae and Spirochaetaceae at family level, which were hardly detected in healthy controls. The WD group had a markedly lower abundance of Actinobacteria, Firmicutes and Verrucomicrobia, and a higher abundance of Bacteroidetes, Proteobacteria, Cyanobacteria and Fusobacteria than that in healthy individuals. The Firmicutes to Bacteroidetes ratio in the WD group was significantly lower than that of healthy control. In addition, the functional profile of the gut microbiome from WD patients showed a lower abundance of bacterial groups involved in the host immune and metabolism associated systems pathways such as transcription factors and ABC-type transporters, compared to healthy individuals. These results implied dysbiosis of gut microbiota may be influenced by the host metabolic disorders of WD, which may provide a new understanding of the pathogenesis and new possible therapeutic targets for WD.

show abstract

“…The human gut microbiome has been confirmed to play a causal role in the development of pathologies in animal models of metabolic disease such as obesity, Alzheimer's disease and Type 1 diabetes (T1D) [17][18][19]. While WD is an autosomal-recessive disorder characterized by abnormal copper metabolism leading to copper excretion disorder and deposition in target organs.…”

Section: Discussionmentioning

confidence: 99%

Altered Diversity and Composition of Gut Microbiota in Wilson's disease

Cai

Deng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Wilson’s disease (WD) is a rare autosomal recessive inherited disorder of chronic copper toxicosis with high mortality and disability. Recent evidence suggests a correlation between dysbiosis in the gut microbiome and metabolic disease. Therefore, the impact of intestinal microbiota polymorphism in WD need to be explore for seeking some microbiota benefit for WD patients. Methods: In this study, the 16S rRNA sequencing was performed on fecal samples from 14 patients with WD and were compared to the results from 16 healthy individuals. The diversity and composition of the gut microbiome in the WD group were significantly lower than those in healthy individuals. Results: The WD group presented unique richness of Gemellaceae , Pseudomonadaceae and Spirochaetaceae at family level in WD group, which were hardly detected in healthy controls The WD group had a markedly lower abundance of Acidobacteria , Firmicutes and Verrucomicrobia , and a higher abundance of Bacteroidet es, Proteobacteria , Cyanobacteria and Fusobacteria than that in healthy individuals. The Firmicutes to Bacteroidetes ratio in the WD group was significantly lower than that of healthy control. The functional profile of the gut microbiome from WD patients showed a lower abundance of bacterial groups involved in the pathways of transcription factors and ABC-type transporters, compared to healthy individuals. The dysbiosis of gut microbiota may be influenced by the host metabolic disorders of WD such as signaling pathway of ABC-type transporters and multiple metabolic modules. Conclusions: This study provides a new understanding of the pathogenesis of WD and new possible therapeutic targets.

show abstract

Correction to: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

Cited by 11 publications

References 1 publication

Recent Advances on Microbiota Involvement in the Pathogenesis of Autoimmunity

Recent Advances on Microbiota Involvement in the Pathogenesis of Autoimmunity

Altered diversity and composition of gut microbiota in Wilson's disease

Altered Diversity and Composition of Gut Microbiota in Wilson's disease

Contact Info

Product

Resources

About