Correction: Wang et al. Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation. Molecules 2018, 23, 391

Wang, Yiding; Zhang, Jing; Zhang, Denghong; Xiao, Huixiang; Xiong, Shengwei; Huang, Chunhong

doi:10.3390/molecules27165269

Cited by 3 publications

(3 citation statements)

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“…Neoadjuvant therapy with alectinib could be effective in achieving complete pathological response in early-stage NSCLC with EML4-ALK rearrangement. [173][174][175][176][177] Ceritinib is a kinase inhibitor in the form of a small molecule, employed for the treatment of metastatic non-small cell lung cancer (NSCLC) with positive anaplastic lymphoma kinase (ALK) in individuals with inadequate clinical response or intolerance to crizotinib. It is a type of ALK inhibitor belonging to the second generation that was developed to overcome crizotinib resistance.…”

Section: -110mentioning

confidence: 99%

A graphSAGE discovers synergistic combinations of Gefitinib, paclitaxel, and Icotinib for Lung adenocarcinoma management by targeting human genes and proteins: the RAIN protocol

Sadeghi,

Kiaei,

Boush

et al. 2024

Preprint

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Background: Adenocarcinoma of the lung is the most common type of lung cancer, and it is characterized by distinct cellular and molecular features. It occurs when abnormal lung cells multiply out of control and form a tumor in the outer region of the lungs. Adenocarcinoma of the lung is a serious and life-threatening condition that requires effective and timely management to improve the survival and quality of life of the patients. One of the challenges in this cancer treatment is finding the optimal combination of drugs that can target the genes or proteins that are involved in the disease process. Method: In this article, we propose a novel method to recommend combinations of trending drugs to target its associated proteins/genes, using a Graph Neural Network (GNN) under the RAIN protocol. The RAIN protocol is a three-step framework that consists of: 1) Applying graph neural networks to recommend drug combinations by passing messages between trending drugs for managing disease and genes that act as potential targets for disease; 2) Retrieving relevant articles with clinical trials that include those proposed drugs in previous step using Natural Language Processing (NLP); 3) Analyzing the network meta-analysis to measure the comparative efficacy of the drug combinations. Result: We applied our method to a dataset of nodes and edges that represent the network, where each node is a drug or a gene, and each edge is a p-value between them. We found that the graph neural network recommends combining Gefitinib, Paclitaxel, and Icotinib as the most effective drug combination to target this cancer associated proteins/genes. We reviewed the clinical trials and expert opinions on these medications and found that they support our claim. The network meta-analysis also confirmed the effectiveness of these drugs on associated genes. Conclusion: Our method is a novel and promising approach to recommend trending drugs combination to target cancer associated proteins/genes, using graph neural networks under the RAIN protocol. It can help clinicians and researchers to find the best treatment options for patients, and also provide insights into the underlying mechanisms of the disease.

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Section: -110mentioning

confidence: 99%

A graphSAGE discovers synergistic combinations of Gefitinib, paclitaxel, and Icotinib for Lung adenocarcinoma management by targeting human genes and proteins: the RAIN protocol

Sadeghi,

Kiaei,

Boush

et al. 2024

Preprint

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“…Two years later, SGR J1935+2154 went into a new active episode (Enoto et al 2022;Palm 2022;Roberts et al 2022) at 2022 October. After the burst forest, at least two radio bursts 221014 and 221021 were captured by CHIME (Dong & Chime/Frb Collaboration 2022), GBT (Maan et al 2022) and Yunnan 40 m radio telescope (Huang et al 2022) and their corresponding X-ray bursts are detected by GECAM, HEBS (GECAM-C), Konus-Wind and Insight-HXMT (Frederiks et al 2022;Wang et al 2022;Younes et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Spin Evolution of the Magnetar SGR J1935+2154

Ge,

Yang,

et al. 2024

Res. Astron. Astrophys.

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Fast radio bursts (FRBs) are short pulses observed in radio frequencies usually originating from cosmological distances. The discovery of FRB 200428 and its X-ray counterpart from the Galactic magnetar SGR J1935+2154 suggests that at least some FRBs can be generated by magnetars. However, the majority of X-ray bursts from magnetars are not associated with radio emission. The fact that only in rare cases can an FRB be generated raises the question regarding the special triggering mechanism of FRBs. Here we report long time spin evolution of SGR J1935+2154 until the end of 2022. According to $\nu$ and $\dot\nu$, the spin evolution of SGR J1935+2154 could be divided into two stages. The first stage evolves relatively steady evolution until April 27, 2020. After the burst activity in 2020, the spin of SGR J1935+2154 shows strong variations, especially for $\dot\nu$. After the burst activity in October 2022, a new spin-down glitch with $\Delta\nu/\nu=(-7.2\pm0.6)\times10^{-6}$ is detected around MJD 59876, which is the second event in SGR J1935+2154. At the end, spin frequency and pulse profile do not show variations around the time of FRB 200428 and radio bursts 221014 and 221021, which supply strong clues to constrain the trigger mechanism of FRB or radio bursts.

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“…Since 2022 October, SGR J1935+2154 has been in a new active episode (Enoto et al 2022;Li et al 2022a;Palm 2022;Roberts et al 2022). After the burst forest, at least two FRB signals were captured by CHIME (Dong & Chime/Frb Collaboration 2022), GBT (Maan et al 2022), and the Yunnan 40 m radio telescope (ATEL 15707), and their corresponding XRBs were detected by GECAM, HEBS(GECAM-C), Konus-Wind and Insight-HXMT (Frederiks et al 2022;Li et al 2022b;Wang et al 2022;Younes et al 2022). Compared to these results, more constraints on the FRB mechanism could be supplied by the timing properties of FRB 200428 and XRBs, such as the time delay and the quasi-periodic oscillation in XRBs (Mereghetti et al 2020;Li et al 2021Li et al , 2022Ridnaia et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Reanalysis of the X-Ray-burst-associated FRB 200428 with Insight-HXMT Observations

Ge¹,

Liu²,

Zhang

et al. 2023

ApJ

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A double-peak X-ray burst from the Galactic magnetar SGR J1935+2154 was discovered to be associated with the two radio pulses of FRB 200428 separated by 28.97 ± 0.02 ms. Precise measurements of the timing and spectral properties of the X-ray bursts are helpful for understanding the physical origin of fast radio bursts. In this paper, we have reconstructed some information about the hard X-ray events, which were lost because the High Energy X-ray Telescope (HE) on board the Insight-HXMT mission was saturated by this extremely bright burst, and used the information to improve the temporal and spectral analyses of the X-ray burst. The arrival times of the two X-ray peaks by fitting the new Insight-HXMT/HE lightcurve with multi-Gaussian profiles are 2.77 ± 0.45 ms and 34.30 ± 0.56 ms after the first peak of FRB 200428, respectively, while these two parameters are 2.57 ± 0.52 ms and 32.5 ± 1.4 ms if the fitting profile is a fast-rise and exponential decay function. The spectrum of the two X-ray peaks could be described by a cutoff power law with cutoff energy ∼60 keV and photon index ∼1.4; the latter is softer than the result obtained in Li et al. when the two X-ray peaks appeared.

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Correction: Wang et al. Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation. Molecules 2018, 23, 391

Abstract: The authors would like to correct an error in the original publication [...]

Cited by 3 publications

References 1 publication

A graphSAGE discovers synergistic combinations of Gefitinib, paclitaxel, and Icotinib for Lung adenocarcinoma management by targeting human genes and proteins: the RAIN protocol

A graphSAGE discovers synergistic combinations of Gefitinib, paclitaxel, and Icotinib for Lung adenocarcinoma management by targeting human genes and proteins: the RAIN protocol

Spin Evolution of the Magnetar SGR J1935+2154

Reanalysis of the X-Ray-burst-associated FRB 200428 with Insight-HXMT Observations

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