Correlação da cadeia ossicular no transoperatório com achados histológicos de colesteatomas

Dornelles, Cristina; Rosito, Letícia Petersen Schmidt; Meurer, Luíse; Costa, Sady Selaimen da; Argenta, Andréia; Alves, Sabrina Lima

doi:10.1590/s0034-72992007000600004

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…Stapes erosion happened in 18 patients (54.5%). These findings differ from the ones from Tos 15 and Dornelles et al 16 who reported incus erosion as the most frequent, followed by the stapes and, later, the malleus.…”

Section: Discussioncontrasting

confidence: 92%

TNF-R2 expression in acquired middle ear cholesteatoma

Vitale¹,

Pereira²,

Alves³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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Acqui red middle ear cholesteatoma is a disease which promotes bone erosion resulting in potentially serious complications. The tumor necrosis factor alpha (TNF-α) is present in cholesteatoma and it is related to bone erosion, as shown by different authors. To understand the aggressiveness characteristics of cholesteatoma is necessary, however, to better address the presence and distribution of their receptors. Objective:To evaluate the expression of type 2 TNF-α receptor (TNF-R2) in fragments of cholesteatoma and correlate it to the degree of inflammation present.Material and methods: observational cross-sectional study, which analyzed 33 fragments of cholesteatomas through histological analysis and immunohistochemistry (using as primary antibody to TNF-R2 LabVision ® brand). The evaluation was performed by means of a qualitative and semiquantitative agreement with the observed intensity. For statistical analysis we used the Fisher exact test and Spearman´s correlation coefficient (considered statistically significant when p ≤ 0.05). Results:The expression of TNF-R2 was present in all fragments, however a statistical analysis showed no correlation or association between inflammation and the expression of TNF-R2.Conclusions: TNF-R2 is present in cholesteatoma of the middle ear, however, its expression is not directly related to the degree of inflammation observed in patients with this disease. Braz J Otorhinolaryngol. 2011;77(4):531-6. REVIEW ARTICLE BJORL

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Section: Discussioncontrasting

confidence: 92%

TNF-R2 expression in acquired middle ear cholesteatoma

Vitale¹,

Pereira²,

Alves³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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Cholesteatoma growth patterns: are there audiometric differences between posterior epitympanic and posterior mesotympanic cholesteatoma?

Rosito

Teixeira

Netto

et al. 2016

Eur Arch Otorhinolaryngol

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The objective of this is to verify whether the hearing impairment caused by posterior epitympanic differed from that caused by posterior mesotympanic cholesteatomas by a cross-sectional study. We evaluated 264 ears of patients with cholesteatoma, who had not been subjected to ear surgery. Otoendoscopy and pure-tone audiometry were performed. Analyzed route involved in cholesteatoma formation: posterior epitympanic or posterior mesotympanic, air-bone gaps at 512-4000 Hz and pure-tone averages. The mean age of the patients enrolled in this study was 33.8 years, and 51.8 % of them was male. Posterior epitympanic cholesteatoma was found in 50.4 % of the study population. When the air-bone gaps were compared, the mesotympanic group had greater thresholds at 500, 2000 Hz, and a greater pure-tone average (P = 0.003, P = 0.03, and P = 0.02, respectively). Posterior mesotympanic cholesteatoma showed greater air-bone gaps thresholds at the speech frequencies than posterior epitympanic cholesteatoma did. Moreover, the two growth patterns were very similar with regard to all other audiometric parameters analyzed in this study.

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Middle Ear Cleft in Chronic Otitis Media: A Clinicohistopathological Study

Sharma

Manjari

Salaria

2011

Indian J Otolaryngol Head Neck Surg

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Chronic mucosal diseases of middle ear cleft or chronic suppurative otitis media has been traditionally defined as a chronic inflammation of the middle ear and mastoid usually associated with perforation of the tympanic membrane and otorrhoea. Understanding the pathology and pathogenesis of chronic suppurative otitis media is important in predicting the management, prognosis and sequelae of the disease. The present prospective study was conducted to evaluate the clinical, intraoperative and histopathological changes in middle ear cleft. 100 patients diagnosed with CSOM who underwent surgery were taken. The mucosa and granulation tissue was removed along with ossicles wherever indicated and sent for histopathological examination. On clinical examination, 72 cases were found to be of tubotympanic type and 28 cases of atticoantral variety. However, intraoperatively, of the tubotympanic cases 8 were found to be of unsafe type which was also proven histologically. Stratified squamous epithelium was revealed in most of the cases accompanied by changes in the submucosa. Ossicular chain was involved in 40 cases with incus being the commonest bone to be eroded.

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Correlação da cadeia ossicular no transoperatório com achados histológicos de colesteatomas

Cited by 5 publications

References 22 publications

TNF-R2 expression in acquired middle ear cholesteatoma

TNF-R2 expression in acquired middle ear cholesteatoma

Cholesteatoma growth patterns: are there audiometric differences between posterior epitympanic and posterior mesotympanic cholesteatoma?

Middle Ear Cleft in Chronic Otitis Media: A Clinicohistopathological Study

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